Yapay Zeka Hızlı Bakış & Çıkarımlar
AI InsightSince genetic polymorphisms often show ethnic differences, further functional studies are needed to evaluatethe genotype and phenotype correlations in large cohorts of various ethnicities.
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Özet
AIM: To investigate the association between the vitamin D receptor (VDR) gene rs2228570 FokI polymorphism and the developmentof lumbar degenerative disc disease (LDDD) in the Turkish population.MATERIAL and METHODS: This was a prospective case-control study that included 45 patients with LDDD and 49 healthyindividuals (control group). The clinical investigations of the LDDD patients consisted of neurological examinations, lumbar magneticresonance imaging studies, visual analog scale (VAS) scores, and Oswestry Disability Index scores. The VDR gene rs2228570 FokIpolymorphism was analyzed via a real-time polymerase chain reaction.RESULTS: Individuals with the VDR GG genotype had a significantly increased risk of LDDD, while those with the AG genotypehad a significantly decreased risk. In addition, the A allele may have a protective effect against LDDD in the Turkish population.Moreover, the VAS pain results showed that the GG genotype had a significantly higher score than the others.CONCLUSION: VDR rs2228570 AG genotype is at a decreased risk and the GG genotype is at an increased risk of LDDD in theTurkish population. Since genetic polymorphisms often show ethnic differences, further functional studies are needed to evaluatethe genotype and phenotype correlations in large cohorts of various ethnicities.