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Dergiler / Turkish Journal of Pharmaceutical Sciences / 2020 / Cilt: 17 - Sayı: 5

Antimicrobial Activities of Some Pyrazoline and Hydrazone Derivatives

Bazı Pirazolin ve Hidrazon Türevlerinin Antimikrobiyal Aktiviteleri

Begüm EVRANOS-AKSÖZ
Suna Sibel GÜRPINAR
Müjde ERYILMAZ
Sayfa
500–505
DOI
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Yapay Zeka Hızlı Bakış & Çıkarımlar

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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

They can be used as lead molecules for the synthesis of more effective compounds.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Objectives: Resistance to antibiotics is recognized as one of the biggest threats to human health worldwide.
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Temel Bulgular & Veri:In this study, two new and 23 previously reported 2-pyrazoline derivatives and one hydrazone derivative were evaluated for their in vitro antibacterial and antifungal activities.
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Sonuç & Katkı:They can be used as lead molecules for the synthesis of more effective compounds.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri

Özet

Objectives: Resistance to antibiotics is recognized as one of the biggest threats to human health worldwide. Frequent and unnecessary use of antibiotics has caused infectious agents to adapt to antibiotics and thus drugs have become less effective. The resistance to many antibiotics necessitates the discovery of new antibiotics. In this study, two new and 23 previously reported 2-pyrazoline derivatives and one hydrazone derivative were evaluated for their in vitro antibacterial and antifungal activities. Materials and Methods: For the determination of the minimum inhibitory concentration (MIC) values of compounds, microbroth dilution was used. Results: The antimicrobial activities of the compounds were found in a wide range with MIC values of 32-512 μg/mL. Conclusion: The synthesized compounds showed moderate antimicrobial activity compared with the standards. They can be used as lead molecules for the synthesis of more effective compounds.

Abstract

Amaç: Antibiyotik direnci, dünya çapında insan sağlığına yönelik en büyük tehditlerden biri olarak kabul edilmektedir. Sık ve gereksiz antibiyotik kullanımı, bulaşıcı organizmaların antibiyotiklere adapte olmasına neden olarak ilaçların daha az etkili hale gelmesine yol açmıştır. Birçok antibiyotiğe karşı gelişen direnç, yeni antibiyotiklerin keşfini gerektirmektedir. Bu çalışmada, daha önce başka etkileri nedeni ile yayınlanmış 23 2-pirazolin ve bir hidrazon türevi ile iki yeni 2-pirazolin türevi bileşiğin, in vitro antibakteriyel ve antifungal aktiviteleri incelenmiştir.Gereç ve Yöntemler: Bileşiklerin minimum inhibitör konsantrasyon (MİK) değerlerinin belirlenmesi için mikrobroth dilüsyon yöntemi kullanıldı.Bulgular: Bileşiklerin antimikrobiyal aktiviteleri, 32-512 μg/mL MİK değerleri ile geniş bir aralıkta bulunmuştur.Sonuç: Sentezlenen bileşikler, standartlarla karşılaştırıldıklarında orta düzeyde antimikrobiyal aktivite göstermiştir ve daha etkili bileşiklerin sentezi için öncü moleküller olarak kullanılabilecekleri sonucuna varılmıştır.

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Bu Makaleye Atıf Yap

EVRANOS-AKSÖZ, B., GÜRPINAR, S. S., ERYILMAZ, M. (2020). Antimicrobial Activities of Some Pyrazoline and Hydrazone Derivatives. Turkish Journal of Pharmaceutical Sciences, Cilt: 17 - Sayı: 5, 500–505. https://ajindex.com/articles/403614

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