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Dergiler / Turkish Journal of Veterinary and Animal Sciences / 2011 / Cilt: 35 - Sayı: 2

Eosinophils in lung tissue in 2 Chilean Criollo horses with exacerbated recurrent airway obstructions “heaves”

Eosinophils in lung tissue in 2 Chilean Criollo horses with exacerbated recurrent airway obstructions “heaves”

Alexander ORTLOFF
Hugo FOLCH
Gabriel MORÁN
Sayfa
93–97
Yayın Tarihi
2011-02-01
DOI
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

This report describes exacerbated heaves with eosinophilic infiltration and p65 activity in the lung tissue without any neutrophil infiltration, which is usually characteristic for this disease.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:We report on 2 cases of recurrent airway obstruction (RAO) observed in Chilean Criollo horses aged 13 and 15 years.
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Temel Bulgular & Veri:The analysis of the recovered cells of bronchoalveolar lavage fluid (BALF) showed high percentages of eosinophils (82% and 80% in the differential cell counts of the 2 horses) and poor responses to bronchodilator and corticosteroid drugs.
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Sonuç & Katkı:This report describes exacerbated heaves with eosinophilic infiltration and p65 activity in the lung tissue without any neutrophil infiltration, which is usually characteristic for this disease.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:eosinophils · p65 homodimers · Chilean Criollo horses

Özet

We report on 2 cases of recurrent airway obstruction (RAO) observed in Chilean Criollo horses aged 13 and 15 years. Both animals were classified as having severe RAO. The analysis of the recovered cells of bronchoalveolar lavage fluid (BALF) showed high percentages of eosinophils (82% and 80% in the differential cell counts of the 2 horses) and poor responses to bronchodilator and corticosteroid drugs. The histopathological lung evaluation showed eosinophilic infiltration in the peribronchial tissue, as well as in the lumen of the bronchi and bronchioli. In both horses, immunohistochemistry confirmed high p65 homodimer activity in bronchial cells. This report describes exacerbated heaves with eosinophilic infiltration and p65 activity in the lung tissue without any neutrophil infiltration, which is usually characteristic for this disease.

Abstract

We report on 2 cases of recurrent airway obstruction (RAO) observed in Chilean Criollo horses aged 13 and 15 years. Both animals were classified as having severe RAO. The analysis of the recovered cells of bronchoalveolar lavage fluid (BALF) showed high percentages of eosinophils (82% and 80% in the differential cell counts of the 2 horses) and poor responses to bronchodilator and corticosteroid drugs. The histopathological lung evaluation showed eosinophilic infiltration in the peribronchial tissue, as well as in the lumen of the bronchi and bronchioli. In both horses, immunohistochemistry confirmed high p65 homodimer activity in bronchial cells. This report describes exacerbated heaves with eosinophilic infiltration and p65 activity in the lung tissue without any neutrophil infiltration, which is usually characteristic for this disease.

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Bu Makaleye Atıf Yap

ORTLOFF, A., FOLCH, H., MORÁN, G. (2011). Eosinophils in lung tissue in 2 Chilean Criollo horses with exacerbated recurrent airway obstructions “heaves”. Turkish Journal of Veterinary and Animal Sciences, Cilt: 35 - Sayı: 2, 93–97. https://ajindex.com/articles/382927

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Kaynakça (7)

  1. Giguère, S., Viel, L., Lee, E., MacKay, R.J., Hernandez, J., Franchini, M.: Cytokine induction in pulmonary airways of horses with heaves and eff ect of therapy with inhaled fl uticasone propionate. Vet. Immunol. Immunopathol., 2002; 85: 147-158. 5. Lavoie, J.P., Maghni, K., Desnoyers, M., Taha, R., Martin, J.G., Hamid, Q.: Neutrophilic airway infl ammation in horses with heaves is characterized by a Th 2-type cytokine profi le. Am. J. Respir. Crit. Care Med., 2001; 164: 1410-1413. Riihimäki, M., Raine, A., Art, T., Lekeux, P., Couëtil, L., Pringle, J.: Partial divergence of cytokine mRNA expression in bronchial tissues compared to broncheoalveolar lavage cells in horses with recurrent airway obstruction. Vet. Immunol. Immunopathol., 2008; 122: 256-264. 7. Bureau, F., Bonizzi, G., Kirschvink, N., Delhalle, S., Desmecht, D., Merville, M.P., Bours, V., Lekeux, P.: Correlation between nuclear factor-kappaB activity in bronchial brushing samples and lung dysfunction in an animal model of asthma. Am. J. Respi. Crit. Care Med., 2000; 161: 1314-1321.
  2. Saunders, C., Bureau, F., Turlej, R., Fiévez, L., Dogné, S., Kirschvink, N., Lekeux, P.: p65 Homodimer activity distal airway cells determines lung dysfunction in equine heaves. Vet. Immunol. Immunopathol., 2001; 80: 315-26. 9. Herszberg, B., Ramos-Barbón, D., Tamaoka, M., Martin, J.G., Lavoie, J.P.: Heaves, an asthma-like equine disease, involves airway smooth muscle remodeling. J. Allergy Clin. Immunol., 2006; 118: 382-388.
  3. Robinson, N.E., Olszewski, M.A., Boehler, D., Berney, C., Hakala, J., Matson,. C, Derksen, F.J.: Relationship between clinical signs and lung function in horses with recurrent airway obstruction (heaves) during a bronchodilator trial. Equine Vet. J., 2000; 32: 393-400.
  4. Sternberger, L.A., Hardy, P.H., Jr, Cuculis, J.J., Meyer, H.G.: Th e unlabeled antibody enzyme of soluble antigen-antibody complex (horseradish-peroxidase-anti horseradish peroxidase) and its use in identifi cation of spirochetes. J. Histochem. Cytochem., 1970; 18: 315-333.
  5. McGorum, B.C., Dixon, P.M., Halliwell, R.E.: Responses of horses aff ected with chronic obstructive pulmonary disease to inhalation challenges with mould antigens. Equine Vet. J., 1993; 25: 261-267.
  6. Robinson, N.E.: International Workshop on Equine Chronic Airway Disease Michigan State University. Equine Vet. J., 2001; 33: 5-19.
  7. McGorum, B., Dixon, P.M.: Th e analysis and interpretation of equine bronchoalveolar lavage fl uid (BALF) cytology. Equine Vet. Educ.,