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Journals / Turkish Journal of Veterinary and Animal Sciences / 2011 / Cilt: 35 - Sayı: 2

Eosinophils in lung tissue in 2 Chilean Criollo horses with exacerbated recurrent airway obstructions “heaves”

Eosinophils in lung tissue in 2 Chilean Criollo horses with exacerbated recurrent airway obstructions “heaves”

Alexander ORTLOFF
Hugo FOLCH
Gabriel MORÁN
Pages
93–97
Publication Date
2011-02-01
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

This report describes exacerbated heaves with eosinophilic infiltration and p65 activity in the lung tissue without any neutrophil infiltration, which is usually characteristic for this disease.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:We report on 2 cases of recurrent airway obstruction (RAO) observed in Chilean Criollo horses aged 13 and 15 years.
📊
Key Findings & Data:The analysis of the recovered cells of bronchoalveolar lavage fluid (BALF) showed high percentages of eosinophils (82% and 80% in the differential cell counts of the 2 horses) and poor responses to bronchodilator and corticosteroid drugs.
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Conclusion & Impact:This report describes exacerbated heaves with eosinophilic infiltration and p65 activity in the lung tissue without any neutrophil infiltration, which is usually characteristic for this disease.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:eosinophils · p65 homodimers · Chilean Criollo horses

Abstract

We report on 2 cases of recurrent airway obstruction (RAO) observed in Chilean Criollo horses aged 13 and 15 years. Both animals were classified as having severe RAO. The analysis of the recovered cells of bronchoalveolar lavage fluid (BALF) showed high percentages of eosinophils (82% and 80% in the differential cell counts of the 2 horses) and poor responses to bronchodilator and corticosteroid drugs. The histopathological lung evaluation showed eosinophilic infiltration in the peribronchial tissue, as well as in the lumen of the bronchi and bronchioli. In both horses, immunohistochemistry confirmed high p65 homodimer activity in bronchial cells. This report describes exacerbated heaves with eosinophilic infiltration and p65 activity in the lung tissue without any neutrophil infiltration, which is usually characteristic for this disease.

Özet

We report on 2 cases of recurrent airway obstruction (RAO) observed in Chilean Criollo horses aged 13 and 15 years. Both animals were classified as having severe RAO. The analysis of the recovered cells of bronchoalveolar lavage fluid (BALF) showed high percentages of eosinophils (82% and 80% in the differential cell counts of the 2 horses) and poor responses to bronchodilator and corticosteroid drugs. The histopathological lung evaluation showed eosinophilic infiltration in the peribronchial tissue, as well as in the lumen of the bronchi and bronchioli. In both horses, immunohistochemistry confirmed high p65 homodimer activity in bronchial cells. This report describes exacerbated heaves with eosinophilic infiltration and p65 activity in the lung tissue without any neutrophil infiltration, which is usually characteristic for this disease.

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Cite This Article

ORTLOFF, A., FOLCH, H., MORÁN, G. (2011). Eosinophils in lung tissue in 2 Chilean Criollo horses with exacerbated recurrent airway obstructions “heaves”. Turkish Journal of Veterinary and Animal Sciences, Cilt: 35 - Sayı: 2, 93–97. https://ajindex.com/articles/382927

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References (7)

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