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Dergiler / Turkish Journal of Chemistry / 2005 / Cilt: 29 - Sayı: 4

O-Galloyl Flavonoids from Geranium pyrenaicum and Their in vitro Antileishmanial Activity

Dilek ERCİL
Maeki KALOGA
Oliver A. RADTKE
M. Koray SAKAR
Albrecht F. KIDERLEN
Herbert KOLODZIEJ
Sayfa
437–443
Yayın Tarihi
2005-04-01
DOI
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Compounds 1-7 were evaluated for antileishmanial activity against a panel of Leishmania species (L. major, L. donovani and L. amazonensis), indicating appreciable in vitro activities (IC50 4-27 nM) when compared with Pentostam (IC50 10-11 nM).

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Amaç & Hipotez:From the aerial parts of Geranium pyrenaicum Burm., a new flavonol glycoside, kaempferol 3-O-(2'',3''-di-O-galloyl)-{\ss}-D-glucopyranoside (7), along with 6 known related glycosides [kaempferol 3-O-b-D-glucopyranoside (1), quercetin 3-O-b-D-glucopyranoside (2), quercetin 3-O-b-D-galactopyranoside (3), kaempferol 3-O-(2''-O-galloyl)-b-D-glucopyranoside (4), quercetin 3-O-(2''-O-galloyl)-b-D-glucopyranoside (5) and quercetin 3-O-(2'',3''-di-O-galloyl)-{\ss}-D-glucopyranoside (6)] and the ellagitannins corilagin (8) and tellimagrandin I (9) were isolated.
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Temel Bulgular & Veri:Their structures were established from spectroscopic studies (UV, FAB-MS, 1H and 13C-NMR, 1H-1H COSY, HETCOR, HMBC).
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Sonuç & Katkı:Compounds 1-7 were evaluated for antileishmanial activity against a panel of Leishmania species (L. major, L. donovani and L. amazonensis), indicating appreciable in vitro activities (IC50 4-27 nM) when compared with Pentostam (IC50 10-11 nM).
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Geranium pyrenaicum · Geraniaceae · Flavonoids

Özet

From the aerial parts of Geranium pyrenaicum Burm., a new flavonol glycoside, kaempferol 3-O-(2'',3''-di-O-galloyl)-{\ss}-D-glucopyranoside (7), along with 6 known related glycosides [kaempferol 3-O-b-D-glucopyranoside (1), quercetin 3-O-b-D-glucopyranoside (2), quercetin 3-O-b-D-galactopyranoside (3), kaempferol 3-O-(2''-O-galloyl)-b-D-glucopyranoside (4), quercetin 3-O-(2''-O-galloyl)-b-D-glucopyranoside (5) and quercetin 3-O-(2'',3''-di-O-galloyl)-{\ss}-D-glucopyranoside (6)] and the ellagitannins corilagin (8) and tellimagrandin I (9) were isolated. Their structures were established from spectroscopic studies (UV, FAB-MS, 1H and 13C-NMR, 1H-1H COSY, HETCOR, HMBC). Compounds 1-7 were evaluated for antileishmanial activity against a panel of Leishmania species (L. major, L. donovani and L. amazonensis), indicating appreciable in vitro activities (IC50 4-27 nM) when compared with Pentostam (IC50 10-11 nM).

Abstract

From the aerial parts of Geranium pyrenaicum Burm., a new flavonol glycoside, kaempferol 3-O-(2'',3''-di-O-galloyl)-{\ss}-D-glucopyranoside (7), along with 6 known related glycosides [kaempferol 3-O-b-D-glucopyranoside (1), quercetin 3-O-b-D-glucopyranoside (2), quercetin 3-O-b-D-galactopyranoside (3), kaempferol 3-O-(2''-O-galloyl)-b-D-glucopyranoside (4), quercetin 3-O-(2''-O-galloyl)-b-D-glucopyranoside (5) and quercetin 3-O-(2'',3''-di-O-galloyl)-{\ss}-D-glucopyranoside (6)] and the ellagitannins corilagin (8) and tellimagrandin I (9) were isolated. Their structures were established from spectroscopic studies (UV, FAB-MS, 1H and 13C-NMR, 1H-1H COSY, HETCOR, HMBC). Compounds 1-7 were evaluated for antileishmanial activity against a panel of Leishmania species (L. major, L. donovani and L. amazonensis), indicating appreciable in vitro activities (IC50 4-27 nM) when compared with Pentostam (IC50 10-11 nM).

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Bu Makaleye Atıf Yap

ERCİL, D., KALOGA, M., RADTKE, O. A., SAKAR, M. K., KIDERLEN, A. F., KOLODZIEJ, H. (2005). O-Galloyl Flavonoids from Geranium pyrenaicum and Their in vitro Antileishmanial Activity. Turkish Journal of Chemistry, Cilt: 29 - Sayı: 4, 437–443. https://ajindex.com/articles/382195

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