Circulating SCUBE1 levels in women with polycystic ovary syndrome

No associationbetween SCUBE1 level and clinical or biochemical parameters was found in the control or PCOS group.Conclusion: SCUBE1 levels are elevated in women with PCOS compared with those in healthy controls; thus, this protein may be an early biomarker ofcardiovascular disease later in life.

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Amaç & Hipotez:Objective: Polycystic ovary syndrome (PCOS) is thought to represent an early manifestation of metabolic syndrome, which is associated with cardiovasculardisease.

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Temel Bulgular & Veri:Signal peptide-CUB (complement C1r/C1s, Uegf, and Bmp1)-epidermal growth factor domain-containing protein 1 (SCUBE1) is a plateletactivation marker that plays important roles in vascular biology and has been closely linked to cardiovascular events.

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Sonuç & Katkı:No associationbetween SCUBE1 level and clinical or biochemical parameters was found in the control or PCOS group.Conclusion: SCUBE1 levels are elevated in women with PCOS compared with those in healthy controls; thus, this protein may be an early biomarker ofcardiovascular disease later in life.

🔬Tür:Araştırma Makalesi

📍Kapsam:Genişletilmiş Akademik Örneklem

⚙️Değişkenler:Alan Parametreleri

Özet

Objective: Polycystic ovary syndrome (PCOS) is thought to represent an early manifestation of metabolic syndrome, which is associated with cardiovasculardisease. Signal peptide-CUB (complement C1r/C1s, Uegf, and Bmp1)-epidermal growth factor domain-containing protein 1 (SCUBE1) is a plateletactivation marker that plays important roles in vascular biology and has been closely linked to cardiovascular events. In the present study, we investigatedSCUBE1 levels in lean glucose-tolerant women with PCOS and assessed the possible association between SCUBE1 levels and hormonal and metabolicfeatures of women with PCOS.Materials and Methods: The study population consisted of 90 lean [body mass index (BMI) <25 kg/m2] women who were diagnosed as having PCOSusing the Rotterdam criteria and 100 age- and BMI-matched healthy controls with no clinical or biochemical feature of hyperandrogenism. Glucosetolerance was evaluated in all subjects before recruitment using the 2 h 75 g oral glucose tolerance test, and only those exhibiting normal glucose tolerancewere enrolled. Hormonal and metabolic parameters, and serum SCUBE1 levels were evaluated.Results: Circulating SCUBE1 levels were significantly higher in women with PCOS than in controls (5.9±3.9 vs. 4.2±1.4 ng/mL, p=0.022). No associationbetween SCUBE1 level and clinical or biochemical parameters was found in the control or PCOS group.Conclusion: SCUBE1 levels are elevated in women with PCOS compared with those in healthy controls; thus, this protein may be an early biomarker ofcardiovascular disease later in life.

Abstract

Amaç: Polikistik over sendromu (PKOS), kardiyovasküler hastalıkla ilişkili olan metabolik sendromun erken bulgusu olarak düşünülmektedir. Signal peptide-CUB (complement C1r/C1s, Uegf, and Bmp1)-epidermal büyüme faktörü domain-containing protein 1 (SCUBE1) vasküler biyolojide önemli rol oynayan ve kardiyovasküler olaylarla yakından ilişkili olan bir trombosit aktivasyon belirtecidir. Bu çalışmada, normal kilo ve glukoz toleransı olan PKOS’li kadınlarda SCUBE1 düzeyleri ve bu düzeylerin hormonal ve metabolik özellikler arasındaki olası ilişkinin değerlendirmesi amaçlanmıştır. Gereç ve Yöntemler: Çalışmaya normal kiloya sahip [vücut kitle indeksi (VKİ) <25 kg/m2 ], Rotterdam kriterlerine göre PKOS tanısı konulan 90 hasta ile yaş ve VKİ eşleştirilmiş klinik ve biyokimyasal hiperandrojenizm bulgusu olmayan 100 kontrol hastası dahil edildi. Tüm olgulara 2 saatlik 75 gr oral glukoz tolerans testi uygulandı ve sadece normal glukoz toleransı olan olgular çalışmaya dahil edildi. Hormonal ve metabolik parametreler, serum SCUBE1 düzeyleri değerlendirildi. Bulgular: SCUBE1 seviyeleri, PKOS’li kadınlarda kontrol grubuna göre anlamlı olarak daha yüksek saptandı (5,9±3,9’a karşı 4,2±1,4 ng/mL, p=0,022). Kontrol veya PKOS grubunda SCUBE1 seviyesi ile klinik veya biyokimyasal parametreler arasında ilişki bulunmadı. Sonuç: PKOS’li kadınlarda SCUBE1 seviyeleri, sağlıklı kontrol grubundakilere göre daha yüksektir; bu nedenle, bu protein yaşamın ileri döneminde gelişebilecek kardiyovasküler hastalıkların erken biyobelirteci olabilir.

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Bu Makaleye Atıf Yap

EROL, O., ELLİDAĞ, H. Y., ÖZEL, M. K., DERBENT, A. U., EREN, E., YILMAZ, N. (2018). Circulating SCUBE1 levels in women with polycystic ovary syndrome. Turkish Journal of Obstetrics and Gynecology, Cilt: 15 - Sayı: 3, 152–158. https://ajindex.com/articles/376449

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Kaynakça (11)

Azziz R, Woods KS, Reyna R, Key TJ, Knochenhauer ES, Yildiz BO. The prevalence and features of the polycystic ovary syndrome in an unselected population. J Clin Endocrinol Metab 2004;89:2745-9.
Caserta D, Adducchio G, Picchia S, Ralli E, Matteucci E, Moscarini M. Metabolic syndrome and polycystic ovary syndrome: an intriguing overlapping. Gynecol Endocrinol 2014;30:397-402.
Türkçüoğlu I, Kafkasli A, Meydanli MM, Ozyalin F, Taşkapan C. Independent predictors of cardiovascular risk in polycystic ovarian syndrome. Gynecol Endocrinol 2011;27:915-9.
Rizzo M, Berneis K, Spinas G, Rini GB, Carmina E. Long-term consequences of polycystic ovary syndrome on cardiovascular risk. Fertil Steril 2009;91(Suppl 4):1563-7.
Grimmond S, Larder R, Van Hateren N, Siggers P, Hulsebos TJ, Arkell R, et al. Cloning, mapping, and expression analysis of a gene encoding a novel mammalian EGF-related protein (SCUBE1). Genomics 2000;70:74-81.
Grimmond S, Larder R, Van Hateren N, Siggers P, Morse S, Hacker T, et al. Expression of a novel mammalian epidermal growth factor-related gene during mouse neural development. Mech Dev 2001;102:209-11.
Haworth K, Smith F, Zoupa M, Seppala M, Sharpe PT, Cobourne MT. Expression of the Scube3 epidermal growth factor-related gene during early embryonic development in the mouse. Gene Expr Patterns 2007;7:630-4.
Yang RB, Ng CK, Wasserman SM, Colman SD, Shenoy S, Mehraban F, et al. Identification of a novel family of cell-surface proteins expressed in human vascular endothelium. J Biol Chem 2002;277:46364-73.
Tu CF, Su YH, Huang YN, Huang YN, Tsai MT, Li LT, et al. Localization and characterization of a novel secreted protein SCUBE1 in human platelets. Cardiovasc Res 2006;71:486-95.
Wu MY, Lin YC, Liao WJ, Tu CF, Chen MH, Roffler SR, et al. Inhibition of the plasma SCUBE1, a novel platelet adhesive protein, protects mice against thrombosis. Arterioscler Thromb Vasc Biol 2014;34:1390-8.
Heit JA, Cunningham JM, Petterson TM, Armasu SM, Rider DN, DE Andrade M. Genetic variation within the anticoagulant, procoagulant, fibrinolytic and innate immunity pathways as risk factors for venous thromboembolism. J Thromb Haemost 2011;9:1133-42. Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group. Revised 2003 consensus on diagnostic criteria and longterm health risks related to polycystic ovary syndrome. Fertil Steril 2004;8:19-25. American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care 2014;37(Suppl 1):81-90. Coskun A,