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Dergiler / The European Research Journal / 2016 / Cilt: 2 - Sayı: 1

Efficacy of antibody levels in different post-exposure rabies vaccination programs

Esra Kaya KİLİC
Cemal BULUT
Meliha Çağla SÖNMEZER
Çiğdem Ataman HATİPOĞLU
Sami KINIKLI
Ali Pekcan DEMİRÖZ
Sayfa
36–41
DOI
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Yapay Zeka Hızlı Bakış & Çıkarımlar

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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Identification of similar seroconversion rates suggests that the 2-1-1 vaccination program may be a good alternative option to the standard vaccination program when RIG is unavailable.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Rabies is a fatal acute viral zoonotic disease causing encephalomyelitis in humans and many other mammalian animals.
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Temel Bulgular & Veri:In 61 (71.8%) patients a 2-1-1 vaccine program (Zagreb regimen) was implemented, and in 24 (28.2%) patients, a 5-dose rabies vaccine and rabies immune globulin (RIG) in a dose of 40 IU/kg (Essen regimen) was applied.
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Sonuç & Katkı:Identification of similar seroconversion rates suggests that the 2-1-1 vaccination program may be a good alternative option to the standard vaccination program when RIG is unavailable.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Antibody · immunization schedule · rabies

Abstract

Objectives. Rabies is a fatal acute viral zoonotic disease causing encephalomyelitis in humans and many other mammalian animals. Prophylaxis is vital since there is no treatment for rabies. This study was a comparison of antibody levels in patients who were vaccinated following different vaccinationprotocols. Methods. Eighty-five patients who were included in the rabies vaccination program who presented to the vaccination center of our clinic with the complaint of suspicious contact with rabies were included the study. In 61 (71.8%) patients a 2-1-1 vaccine program (Zagreb regimen) was implemented, and in 24 (28.2%) patients, a 5-dose rabies vaccine and rabies immune globulin (RIG) in a dose of 40 IU/kg (Essen regimen) was applied. Results. In patients on the 2-1-1 vaccine program, antibody levels on the 21st day were greater than 0.5 IU/ml in 49 (80.3%) patients. Antibody levels on the 28th day in the group that received the 5-dose rabies vaccine and rabies immune globulin administration was greater than 0.5 IU/ml in 17 (70.8%) patients. The difference between the two groups of vaccination programs was not statistically significant (p=0.344). Seroconversion rates for approximately one month after the last dose of vaccination in the serum samples were 90% and 75% in the groups with 2-1-1 vaccination, and RIG and 5-dose vaccinations, respectively. The differences were not statistically significant (p=0.071). Conclusions. Identification of similar seroconversion rates suggests that the 2-1-1 vaccination program may be a good alternative option to the standard vaccination program when RIG is unavailable.

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Bu Makaleye Atıf Yap

KİLİC, E. K., BULUT, C., SÖNMEZER, M. Ç., HATİPOĞLU, Ç. A., KINIKLI, S., DEMİRÖZ, A. P. (2016). Efficacy of antibody levels in different post-exposure rabies vaccination programs. The European Research Journal, Cilt: 2 - Sayı: 1, 36–41. https://ajindex.com/articles/361272

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Kaynakça (8)

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