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Dergiler / The European Research Journal / 2019 / Cilt: 5 - Sayı: 2

Regenerative effect of platelet-rich fibrin on articular cartilage defects in an experimental rat model

Hasan METİNEREN
Turan Cihan DÜLGEROĞLU
Sayfa
299–305
DOI
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Conclusions: Similar to its role in various tissues, platelet-rich fibrin is an effective biomaterial that enhances the healing of osteochondral defects.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Objectives: Different materials are currently being used experimentally to accelerate cartilage healing and to obtain hyaline cartilage.
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Temel Bulgular & Veri:Methods: Twenty rats were used in this study. platelet-rich fibrin was obtained from 4 rats, and the remaining 16 rats were randomly divided into two groups (4 and 8 weeks).
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Sonuç & Katkı:Conclusions: Similar to its role in various tissues, platelet-rich fibrin is an effective biomaterial that enhances the healing of osteochondral defects.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Articular cartilage · chondral healing · experimental rat model

Abstract

Objectives: Different materials are currently being used experimentally to accelerate cartilage healing and to obtain hyaline cartilage. We aimed to investigate the effect of platelet-rich fibrin on joint cartilage healing. Methods: Twenty rats were used in this study. platelet-rich fibrin was obtained from 4 rats, and the remaining 16 rats were randomly divided into two groups (4 and 8 weeks). Both knee joints were prepared, and an osteochondral defect was created at the femoral condyle in all rats. platelet-rich fibrin was placed into the osteochondral defect of the right knee, while the left knee joint was used as a control. Groups were sacrificed after 4 and 8 weeks, respectively. Results: According to the O'Driscoll score, there were no significant differences between the right and left knee scores in group 4 weeks (p = 0.820). However, the right knee scores were significantly different than the left knee scores in group 8 weeks (p < 0.001). Defects were completely filled with cartilage tissue after 8 weeks in the platelet-rich fibrin group. Conclusions: Similar to its role in various tissues, platelet-rich fibrin is an effective biomaterial that enhances the healing of osteochondral defects.

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Bu Makaleye Atıf Yap

METİNEREN, H., DÜLGEROĞLU, T. C. (2019). Regenerative effect of platelet-rich fibrin on articular cartilage defects in an experimental rat model. The European Research Journal, Cilt: 5 - Sayı: 2, 299–305. https://ajindex.com/articles/361245

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Kaynakça (10)

  1. Sophia Fox AJ, Bedi A, Rodeo SA. The basic science of articular cartilage: structure, composition, and function. Sports Health 2009;1:461-8
  2. Buma P, Pieper JS, Van Tienen T, Van Susante JL, Van der Kraan PM, Veerkamp JH, et al. Cross-linked type I and type II collagenous matrices for the repair of full-thickness articular cartilage defects: a study in rabbits. Biomaterials 2003;24:3255-63
  3. Dohan Ehrenfest DM, Rasmusson L, Albrektsson T. Classification of platelet concentrates: from pure platelet-rich plasma (P-PRP) to leucocyte- and platelet-rich fibrin (L-PRF). Trends Biotechnol 2009;27:158-67
  4. Choukroun J, Adda F, Schoeffler C, Vervelle A. [An opportunity in perio-implantology: the PRF]. Implantodontie 2001;42:55-62. [Article in French] [5] Choukroun J, Diss A, Simonpieri A, Girard MO, Schoeffler C, Dohan SL, et al. Platelet-rich fibrin (PRF): A second-generation platelet concentrate. Part IV: Clinical effects on tissue healing. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2006;101:e56-60
  5. Choukroun J, Diss A, Simonpieri A, Girard MO, Schoeffler C, Dohan SL, et al. Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part V: Histologic evaluations of PRF effects on bone allograft maturation in sinus lift. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2006;101:299-303
  6. Dohan DM, Choukroun J, Diss A, Dohan SL, Dohan AJ, Mouhyi J, et al. Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part II: Platelet-related biologic features. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2006;101:e45-50
  7. Dohan DM, Choukroun J, Diss A, Dohan SL, Dohan AJ, Mouhyi J, et al. Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part I: Technological concepts and evolution. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2006;101:e37-44
  8. Masuki H, Okudera T, Watanebe T, Suzuki M, Nishiyama K, Okudera H, et al. Growth factor and pro-inflammatory cytokine contents in platelet-rich plasma (PRP), plasma rich in growth factors (PRGF), advanced platelet-rich fibrin (A-PRF), and concentrated growth factors (CGF). Int J Implant Dent 2016;2:19
  9. He L, Lin Y, Hu X, Zhang Y, Wu H. A comparative study of platelet-rich fibrin (PRF) and platelet-rich plasma (PRP) on the effect of proliferation and differentiation of rat osteoblasts in vitro. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2009;108:707-13
  10. O'Driscoll SW, Keeley FW, Salter RB. The chondrogenic potential of free autogen