The molecular docking study found that both compounds were bound into the active site of the N-terminal of MGAM, and thus agreed with the in vitro α-glucosidase enzyme inhibition activity results.
📌 3 Maddede Bu Makale
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Amaç & Hipotez:Abstract: A phytochemical investigation of the methanolic extract of Endiandra kingiana (bark) led to the isolation of four major compounds which are kingianic acid A (1), tsangibeilin B (2), kingianin A (3) and kingianin F (4).
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Temel Bulgular & Veri:The structures were determined by 1D- and 2D-NMR analysis in combination with HRMS experiments.
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Sonuç & Katkı:The molecular docking study found that both compounds were bound into the active site of the N-terminal of MGAM, and thus agreed with the in vitro α-glucosidase enzyme inhibition activity results.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri
Özet
Abstract: A phytochemical investigation of the methanolic extract of Endiandra kingiana (bark) led to the isolation of four major compounds which are kingianic acid A (1), tsangibeilin B (2), kingianin A (3) and kingianin F (4). The structures were determined by 1D- and 2D-NMR analysis in combination with HRMS experiments. The compounds were screened for their in vitro α-glucosidase inhibition activity. Among them, compounds 3-4 showed potent α-glucosidase inhibition activity with IC50 value at 11.9 ± 2.0 μM and 19.7 ± 1.5 μM, respectively. The molecular docking study found that both compounds were bound into the active site of the N-terminal of MGAM, and thus agreed with the in vitro α-glucosidase enzyme inhibition activity results.
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Bu Makaleye Atıf Yap
AZMİ, M. N., SAAD, N. A., BAKAR, M. H. A., OMAR, M. T. C., AZİZ, A. N., WAHAB, H., SİDDİQ, S., CHOUDHARY, M. I., LİTAUDON, M., AWANG, K. (2021). Cyclic Polyketides with α-Glucosidase Inhibitory Activity from Endiandra kingiana Gamble and Molecular Docking Study. Records of Natural Products, Cilt: 15 - Sayı: 5, 414–419. https://ajindex.com/articles/319795
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