Dergiler / Selçuk Tıp Dergisi / 2018 / Cilt: 34 - Sayı: 4

Comparison of The Gadoxetic Acid and Gadopentate Dimeglumine Efficiency for Determining Liver Metastases by an Enhanced MRI of Patients with Gastrointestinal Malignancies

GİS Malignitesi Bulunan Hastaların Karaciğer Metastazlarının MRG ile Görüntülenmesinde Gadoksetik Asit ve Gadopentate Dimegluminin Etkinliğinin Karşılaştırılarak Değerlendirilmesi

Sayfa
148–154
DOI
—
🏛️Bu makalenin bibliyografik verileri ve tam metin bağlantısı DergiPark üzerinden sağlanmıştır.
DergiPark Kaydı ↗
✨

Yapay Zeka Hızlı Bakış & Çıkarımlar

AI Insight
⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

When the hepatic parenchymal enhancement increased and the enhancement of metastatic lesions reduced, thus the enhancement difference between normally hepatic parenchyma and metastatic lesions might help the detection of the lesions especially in the 20th minute series.

📌 3 Maddede Bu Makale

🎯
Amaç & Hipotez:Aim: The aim of this study was to evaluate the efficacy of gadoxetic acid and gadopentate dimeglumine in the evaluation of liver metastases of patients with gastrointestinal malignancy by magnetic resonance.
📊
Temel Bulgular & Veri:Patients and Methods: A total of 50 patients were diagnosed gastrointestinal malignancies histopathologically were included in the study and their hepatic metastases were examined by magnetic resonance for gadoxetic acid and gadopentate dimeglumine.
💡
Sonuç & Katkı:When the hepatic parenchymal enhancement increased and the enhancement of metastatic lesions reduced, thus the enhancement difference between normally hepatic parenchyma and metastatic lesions might help the detection of the lesions especially in the 20th minute series.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri

Özet

Aim: The aim of this study was to evaluate the efficacy of gadoxetic acid and gadopentate dimeglumine in the evaluation of liver metastases of patients with gastrointestinal malignancy by magnetic resonance. Patients and Methods: A total of 50 patients were diagnosed gastrointestinal malignancies histopathologically were included in the study and their hepatic metastases were examined by magnetic resonance for gadoxetic acid and gadopentate dimeglumine. Arterial, portal and late phase images obtained for these contrast agent and also 20th minutes images obtained for gadoxetic acid. Results: There was statistically significant difference between the series obtained at the 20th minutes after administration of gadoxetic acid and late phase with gadopentate dimeglumine for hepatic parenchymal and metastatic lesion intensity (p 0.05). After the administration of gadoxetic acid, arterial, portal, late phase and the 20th minute series intensity of hepatic enhancement significantly reduced. At this time there was not a significant enhancement of the metastatic lesions. (p>0.05) Conclusion: Gadoxetic acid, a hepatoceluler contrast agent, have important diagnostic contribution to the assessment of the patients with liver metastases of gastrointestinal malignancies by magnetic resonance imaging. When the hepatic parenchymal enhancement increased and the enhancement of metastatic lesions reduced, thus the enhancement difference between normally hepatic parenchyma and metastatic lesions might help the detection of the lesions especially in the 20th minute series.

Abstract

Amaç: Bu çalışmanın amacı gastrointestinal sistem malignitesi bulunan hastaların karaciğer metastazlarının manyetik rezonans görüntüleme (MRG) ile görüntülenmesinde gadoksetik asit ve gadopentate dimegluminin etkinliğinin karşılaştırılarak değerlendirilmesidir. Hastalar ve Yöntem: Çalışmaya histopatolojik olarak gastrointestinal sistem malignitesi bulunan 50 hasta dahil edilerek bu hastalardaki karaciğer metastazları değerlendirilmiştir. Çalışmada etkinliğini araştırdığımız gadoksetik asit ve gadopentate dimeglumine ile elde edilen arteryel, portal, geç faz ve gadoksetik asite özel 20.dakikada elde edilen seriler karaciğer parankim kontrastlanması ve metastatik lezyon kontrastlanması açısından karşılaştırılmıştır. Bulgular: Her iki kontrast madde için elde edilen serilerde; gadoksetik asit uygulanan hastalarda 20. dakikada elde edilen seriler ile gadopentate dimeglumine uygulanmasını takiben geç fazda elde edilen seriler karaciğer parankiminin ve metastatik lezyonun intensitesi açısından karşılaştırıldığında gadoksetik asit lehine anlamlı fark tespit edilmiştir (p 0.05). Gadoksetik asit uygulamasını takiben arteryel, portal, geç fazda ve 20. dakika serilerde karaciğer parankim intensitesinde fazlar süresince istatistiksel anlamlı kontrastlanma artışına yol açmaktadır (p 0.05). Sonuç: Gadoksetik asit hepatoselüler bir kontrast madde olup gastrointestinal sistem maligniteli hastaların karaciğer metastazlarının manyetik rezonans ile değerlendirilmesinde önemli tanısal katkılar sağlar. Özellikle gadoksetik asit ile 20. dakikada elde edilen serilerde karaciğer kontrastlanması artarken metastatik lezyonlardaki kontrastlanmanın artmıyor olması karaciğerdeki metastatik lezyon ve normal karaciğer parankimi arasında belirgin kontrast farkına yol açmaktadır.

🔖

Bu Makaleye Atıf Yap

KADIYORAN, C., ÇİZMECİOĞLU, H. A., ÇİZMECİOĞLU, A., YILMAZ, P. D., POYRAZ, N. (2018). Comparison of The Gadoxetic Acid and Gadopentate Dimeglumine Efficiency for Determining Liver Metastases by an Enhanced MRI of Patients with Gastrointestinal Malignancies. Selçuk Tıp Dergisi, Cilt: 34 - Sayı: 4, 148–154. https://ajindex.com/articles/319270

📄 Tam Metin PDF Okuyucu

📄

PDF görüntüleyici hazırlanıyor...

Kaynakça (14)

  1. Schima W, Kulinna C, Langenberger H, et al. Liver metastases of colorectal cancer: US, CT or MR? Cancer Imaging 2005;5:149-56
  2. Kim YK, Park G, Kim CS, et al. Diagnostic ef cacy of gadoxetic acid-enhanced MRI for the detection and characterisation of liver metastases: Comparison with multidetector-row CT. Br J Radiol 2012;85:539-47
  3. Guo Y, Li W, Cai W, et al. Diagnostic value of gadoxetic acidenhanced MR imaging to distinguish HCA and its subtype from FNH: A systematic review. Int J Med Sci 2017;14:668- 74
  4. Bellin MF. MR contrast agents, the old and the new. Eur J of Radiol 2006;60:314-23
  5. Tsurusaki M, Sofue K, Murakami T. Current evidence for the diagnostic value of gadoxetic acid-enhanced magnetic resonance imaging for liver metastasis. Hepatol Res 2016;46:853-61
  6. Huppertz A, Balzer T, Blakeborough A, et al. Improved detection of focal liver lesions at MR imaging: Multicenter comparison of Gadoxetic Acid-enhanced MR images with intraoperative findings. Radiol 2004;230:266-75
  7. Stern W, Schichk F, Kopp AF, et al. Dynamic MR imaging of liver metastases with Gd-EOB-DTPA. Acta Radiol 2000;41:255-62
  8. Brismar TB, Dahlström N, Edsborg N,et al. Liver vessel enhancement by Gd-BOPTA and Gd-EOB-DTPA: A comparison in healthy volunteers. Acta Radiol 2009;50:709- 15
  9. Voggel T, Kummel S, Hammmerstingl R, et al. Liver tumours: Comparison of MR imaging with Gd-EOB-DTPA and GdDTPA. Radiology 1996;200:59-67
  10. Hammerstingl R, Zangos S, Schwarz W, et al. Contrastenhanced MRI of focal liver tumors, Using a hepatobiliary MR contrast: Detection and differential diagnosis using GdEOB-DTPA-enhanced versus Gd-DTPA-enhanced MRI in the same patient. Acad Radiol 2002;9:119-20
  11. Filippone A, Blakeborough A, Breuer J, et al. Enhancement of liver parenchyma after injection of hepatocyte-spesific MRI contrast media: A comparison of gadoxetic acid and gadobenate dimeglumine. J Magn Reson Imaging 2010;31:356-64
  12. Lee KH, Lee JM, Park JH, et al. MR imaging in patients with suspected liver metastases: Value of liver-specific contrast agent gadoxetic acid. Korean J Radiol 2013;14:894-904
  13. Lauenstein T, Ramirez-Garrido F, Kim YH, et al. Nephrogenic systemic fibrosis risk after liver magnetic resonance imaging with gadoxetate disodium in patients with moderate to severe renal impairment: Results of a prospective, open-label, multicenter study. Invest Radiol 2015;50:416-22
  14. Endrikat J, Kim SY, Sakaguchi T, et al. Safety of gadoxetate disodium: Results fr