Dergiler / Selçuk Tıp Dergisi / 2019 / Cilt: 35 - Sayı: 1

Placenta and Umbilical Cord Histopathologies in Pathologic Specimens and Relationship Between Pregnancy Outcomes

Patolojik Spesmenlerde Plasenta ve Umbilikal Kord Histopatolojileri ve Gebelik Sonuçları Arasındaki İlişki

Sayfa
1–8
DOI
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Conclusion: Based on the findings obtained in present study, the regular gestational USG follow-up and a good gestational hemorrhage anamnesis may be useful in predicting or preventing these pathologies in terms of abortus that can be seen in SCH, preterm delivery, and the psychomotor pathologies that can be seen in further years in case of intrauterine growth retardation (IUGR) and short cord length.

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Amaç & Hipotez:Aim: The objectives of this study are to investigate the placenta and umbilical cord specimens histopathologically, and to determine the relationship between pregnancy outcomes.
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Temel Bulgular & Veri:Patients and Methods: 112 placenta specimens obtained from the archive of Uşak University Education and Research Hospital of Pathology Department were retrospectively evaluated.
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Sonuç & Katkı:Conclusion: Based on the findings obtained in present study, the regular gestational USG follow-up and a good gestational hemorrhage anamnesis may be useful in predicting or preventing these pathologies in terms of abortus that can be seen in SCH, preterm delivery, and the psychomotor pathologies that can be seen in further years in case of intrauterine growth retardation (IUGR) and short cord length.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri

Özet

Aim: The objectives of this study are to investigate the placenta and umbilical cord specimens histopathologically, and to determine the relationship between pregnancy outcomes. Patients and Methods: 112 placenta specimens obtained from the archive of Uşak University Education and Research Hospital of Pathology Department were retrospectively evaluated. The criteria of term placenta measurement were determined as 37-40 weeks, 18 cm size, 350-750g weight, 2-2.5 cm thickness in accordance with the Kaufmann’s Pathology. Umbilical cord's number of vessels, membrane structure, chorioangioma, infarct, hematoma, and hemorrhage were recorded. Infarct, chorioamnionitis, sub- chorionic fibrin deposition, congestion of chorionic vessel, sub-chorionic hemorrhage (SCH), chorangiosis, chorioangioma, calcification, perivillous fibrin deposition, effect of meconium, fibrinoid necrosis, villitis, and ectasia of chorionic vessel were found in histopathological examinations. The gender, mode of delivery, maternal disease, birth weight, maternal age, parity, birth length, head circumference, and APGAR scores between 0-9 were recorded. Results: 112 placental specimens were evaluated. As a result of evaluations, 4 of 29 (13.7%) placental infarct cases, 2 of 19 (10.5%) placental chorangiosis cases, one of 17 (5.8%) SCH cases, 2 of 29 (6.8%) chorioamnionitis cases, and one of 12 (8.3%) umbilical cord congestion cases were found to have abnormal pregnancy outcomes. Statistically significant relationships were found between sub-chorionic hemorrhage and placenta size (p = 0.004), between maternal age and umbilical cord dimension (p = 0.001), and between birth weight and placenta and umbilical cord dimensions (p = 0.000). However, no association was found between these parameters and pregnancy outcomes. The relationship was determined between birth weight, placenta and umbilical cord size among diabetes, preterm delivery, ablatio placenta, and stillbirths and pregnancies. No significant association was found between histopathological findings and pregnancy outcomes. Conclusion: Based on the findings obtained in present study, the regular gestational USG follow-up and a good gestational hemorrhage anamnesis may be useful in predicting or preventing these pathologies in terms of abortus that can be seen in SCH, preterm delivery, and the psychomotor pathologies that can be seen in further years in case of intrauterine growth retardation (IUGR) and short cord length.

Abstract

Amaç: Bu çalışmanın amacı plasenta ve göbek kord spesmenlerinin histopatolojik olarak incelemesi ve gebelik sonuçları arasındaki ilişkiyi saptamaktır. Hastalar ve Yöntem: Uşak Üniversitesi Eğitim ve Araştırma Hastanesi Patoloji Ana Bilim Dalı arşivinden 112 plasenta materyali retrospektif olarak değerlendirildi. Term plasenta ölçümü, Kaufmann’ın Patolojisine göre; 37-40 hafta, boyut 18 cm, ağırlık 350-750 gr, kalınlık 2-2,5 cm olarak yapıldı. Göbek kordonunun damar sayısı, membran yapısı, koranjiyom, infarkt, hematom, hemoraji kaydedildi. Histopatolojik olarak infarkt, koryoamniyonit, subkoryonik fibrin birikimi, koryonik damarlarda konjesyon, subkoryonik hemoroji (SCH), koranjiozis, koranjiyom, kalsifikasyon, perivillöz fibrin birikimi, mekonyum etkisi, fibrinoid nekroz, villit, koryonik damarın ektazisi saptandı. Cinsiyet, doğum şekli, maternal hastalık, doğum ağırlığı, anne yaşı, parite, doğum uzunluğu, baş çevresi ve 0-9 arasında APGAR skoru kaydedildi. Bulgular: 112 plasenta spesmeni değerlendirildi; 29 plasental infarkt vakasının 4'ünde (% 13,7), 19 koranjiosis vakasının 2’sinde (% 10,5), 17 SCH vakasının 1’inde (% 5,8), 29 koryoamniyonit vakasının 2’sinde (% 6,8), 12 umbilikal kord konjesyonlu vakanın 1’inde (% 8,3) anormal gebelik sonuçları tespit edildi. İstatistiksel olarak anlamlı sonuçlarımız subkoryonik hemoraji ile plasenta boyutu (p = 0,004), maternal yaş ile umbilikal kord boyutu (p = 0,001) ve doğum ağırlığı ile plasenta ve umbilikal kord boyutları arasında saptandı (p = 0,000). Ancak bu parametreler ile gebelik sonuçları arasında bir ilişkiye rastlanmadı. Diyabet, erken doğum, ablatio plasenta ve ölü doğumla sonuçlanan ve seyreden gebeliklerde, bebek ağırlığı ile plasenta ve umbilikal kord boyutu arasında ilişki saptandı. Histopatolojik bulgular ve gebelik sonuçları arasında ise anlamlı bir ilişkiye rastlanmadı. Sonuç: Çalışmamızdaki temel bulgularımızdan SCH’de görülebilecek abortus, preterm eylem ve intrauterin gelişim geriliği (IUGR) ile kısa kord boyutlarında ileriki yıllarda görülebilecek psikomotor patolojiler açısından düzenli gestasyonel USG takipleri ve iyi bir gebelik kanama anamnezinin bu patolojileri öngörebilme veya önleyebilme de etkin olacağı kanısındayız.

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Bu Makaleye Atıf Yap

KÜÇÜK, Ş., ŞENYUVA, İ. (2019). Placenta and Umbilical Cord Histopathologies in Pathologic Specimens and Relationship Between Pregnancy Outcomes. Selçuk Tıp Dergisi, Cilt: 35 - Sayı: 1, 1–8. https://ajindex.com/articles/319032

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