Dergiler / Southern Clinics of Istanbul Eurasia / 2019 / Cilt: 30 - Sayı: 2

Stereotactic Radiosurgery in Brain Cavernomas: Single-Center Experience

Beyin Kavernomlarında Stereotaktik Radyocerrahi: Tek Merkez Deneyimi

Sayfa
171–174
DOI
—
🏛️Bu makalenin bibliyografik verileri ve tam metin bağlantısı DergiPark üzerinden sağlanmıştır.
DergiPark Kaydı ↗
✨

Yapay Zeka Hızlı Bakış & Çıkarımlar

AI Insight
⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Conclusion: In cavernoma patients with a high risk for surgical intervention and/or patients with high risk for bleeding, SRS is an effective and alternative treatment to surgery.

📌 3 Maddede Bu Makale

🎯
Amaç & Hipotez:Objective: In this study, we aimed to present our treatment results involving patients with intracranial cavernomas who were treated with stereotactic radiosurgery (SRS) by using a CyberKnife®.
📊
Temel Bulgular & Veri:Methods: Between April 2010 and December 2017, data from 19 patients treated with SRS in our clinic with the diagnosis of cavernomas were retrospectively evaluated.
💡
Sonuç & Katkı:Conclusion: In cavernoma patients with a high risk for surgical intervention and/or patients with high risk for bleeding, SRS is an effective and alternative treatment to surgery.
🔬Tür:Araştırma Makalesi
📍Kapsam:2010 Verileri
⚙️Değişkenler:Alan Parametreleri

Özet

Objective: In this study, we aimed to present our treatment results involving patients with intracranial cavernomas who were treated with stereotactic radiosurgery (SRS) by using a CyberKnife®. Methods: Between April 2010 and December 2017, data from 19 patients treated with SRS in our clinic with the diagnosis of cavernomas were retrospectively evaluated. Results: The median follow-up time was 82 months (range: 9–100 months). SRS was performed in the median 1 fraction (range: 1–3); according to the lesion size, the prescription dose ranged from 12 to 21 Gy (median: 15 Gy). During the post-SRS follow-up period, 6 out of the 10 patients with a headache had a complete response, 3 patients had a partial response, and 1 patient had no response. Further, 3 out of the 4 patients with a seizure had a partial response and 1 patient had a stable response in seizure frequency. Furthermore, 1 out of the 2 patients with a vision problem had a complete response and 1 had no change. Also, 1 out of the 3 patients with hemiparesthesia had a complete response and 2 had no change. Radiological evaluations in the post-SRS follow-up period revealed a complete response in 4 patients, partial response in 3 patients, stable disease in 9 patients, and progression in 3 patients. Rebleeding was detected in 1 (5.3%) out of 3 progressive patients at the 17th month, and radiation-induced radionecrosis was detected in the other 2 patients at the 9th and 11th months. There were no procedure-related complications resulting in mortality. Conclusion: In cavernoma patients with a high risk for surgical intervention and/or patients with high risk for bleeding, SRS is an effective and alternative treatment to surgery.

Abstract

Amaç: Bu çalışmada, CyberKnife kullanarak stereotaktik radyocerrahi (SRC) ile tedavi edilen intrakranial Kavernom tanılı hastaların tedavi sonuçlarını sunmayı amaçladık. Gereç ve Yöntem: Nisan 2010–Aralık 2017 tarihleri arasında kliniğimizde Kavernom tanısı ile SRC uygulanan 19 hastanın verileri geriye dönük olarak değerlendirildi. Bulgular: Medyan takip süresi 82 (9–100) aydı. SRC tedavisi medyan 1 fraksiyonda (1–3) yapıldı ve lezyonun büyüklüğüne göre reçetelenen doz 12–21 (medyan 15) Gy arasındaydı. SRC sonrası takip döneminde, baş ağrısı olan 10 hastanın altısında tam yanıt, üçünde kısmi yanıt elde edildi ve birinde ise yanıt alınamadı. Nöbet öyküsü olan dört hastanın üçünde kısmi yanıt, birinde ise nöbet sıklığında stabil yanıt elde edildi. Görme problemleri olan iki hastanın birinde tam yanıt saptanırken birinde ise değişiklik saptanmadı. Hemiparestezisi olan üç hastanın birinde tam yanıt saptanırken ikisinde ise değişiklik saptanmadı. SRC sonrası radyolojik olarak dört hastada tam yanıt, üç hastada kısmi yanıt, dokuz hastada stabil hastalık elde edilirken üç hastada ise progresyon saptandı. Progresyon tespit edilen üç hastanın birinde 17. ayda (%5.3) tekrardan kanama, diğer iki hastada ise dokuzuncu ve 11. aylarda radyonekroz tespit edildi. Mortalite ile sonuçlanan işlemle ilgili herhangi bir komplikasyon görülmedi. Sonuç: Cerrahi müdahale için yüksek risk taşıyan kavernom tanılı hastalarda ve/veya özellikle kanama riskinin yüksek olduğu hastalarda SRC tedavisi cerrahiye alternatif etkili bir tedavi yöntemidir.

🔖

Bu Makaleye Atıf Yap

YAPRAK, G., ÖZEN, A., DEMİR, H., TUĞRUL, F., GÜL, Ş. K., IŞIK, N. (2019). Stereotactic Radiosurgery in Brain Cavernomas: Single-Center Experience. Southern Clinics of Istanbul Eurasia, Cilt: 30 - Sayı: 2, 171–174. https://ajindex.com/articles/314042

📄 Tam Metin PDF Okuyucu

📄

PDF görüntüleyici hazırlanıyor...

Kaynakça (14)

  1. Abla A, Wait SD, Uschold T, Lekovic GP, Spetzler RF. Developmental venous anomaly, cavernous malformation, and capillary telangiectasia: spectrum of a single disease. Acta Neurochir (Wien) 2008;150:487−9
  2. Karabulut Gul S, Mayadagli A, Ozseker N, Kocak M, Oruc AF, Gedik D, et al. Kavernom Tedavisinde Stereotaktik Radyoterapi. Turkiye Klinikleri J Med Sci 2014;34:29−32
  3. Aboukais R, Estrade L, Devos P, Blond S, Lejeune JP, Reyns N. Gamma Knife Radiosurgery of Brainstem Cavernous Malformations. Stereotact Funct Neurosurg 2016;94:397−403
  4. Kondziolka D, Lunsford LD, Flickinger JC, Kestle JR. Reduction of hemorrhage risk after stereotactic radiosurgery for cavernous malformations. J Neurosurg 1995;83:825−31
  5. Hasegawa T, McInerney J, Kondziolka D, Lee JY, Flickinger JC, Lunsford LD. Long-term results after stereotactic radiosurgery for patients with cavernous malformations. Neurosurgery 2002;50:1190−7
  6. Liu KD, Chung WY, Wu HM, Shiau CY, Wang LW, Guo WY, et al. Gamma knife surgery for cavernous hemangiomas: an analysis of 125 patients. J Neurosurg 2005;102:81−6
  7. Nagy G, Razak A, Rowe JG, Hodgson TJ, Coley SC, Radatz MW, et al. Stereotactic radiosurgery for deep-seated cavernous malformations: a move toward more active, early intervention. Clinical article. J Neurosurg 2010;113:691−9
  8. Monaco EA, Khan AA, Niranjan A, Kano H, Grandhi R, Kondziolka D, et al. Stereotactic radiosurgery for the treatment of symptomatic brainstem cavernousmalformations. Neurosurg Focus 2010;29:E11
  9. Lunsford LD, Khan AA, Niranjan A, Kano H, Flickinger JC, Kondziolka D. Stereotactic radiosurgery for symptomatic solitary cerebral cavernous malformationsconsidered high risk for resection. J Neurosurg 2010;113:23−9
  10. Amin-Hanjani S, Ogilvy CS, Candia GJ, Lyons S, Chapman PH. Stereotactic radiosurgery for cavernous malformations: Kjellberg’s experience with proton beam therapy in 98 cases at the Harvard Cyclotron. Neurosurgery 1998;42:1229−36
  11. Karlsson B, Kihlström L, Lindquist C, Ericson K, Steiner L. Radiosurgery for cavernous malformations. J Neurosurg 1998;88:293−7
  12. Pollock BE, Garces YI, Stafford SL, Foote RL, Schomberg PJ, Link MJ. Stereotactic radiosurgery for cavernous malformations. J Neurosurg 2000;93:987−91
  13. Pollock BE. Radiosurgery for cavernous malformations: theory and practice. Clin Neurosurg 2008;55:97−100
  14. Fuetsch M, El Majdoub F, Hoevels M, Müller RP, Sturm V, Maarouf M. Stereotactic LINAC radiosurgery for the treatment of brainstem