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Dergiler / Records of Natural Products / 2019 / Cilt: 13 - Sayı: 5

NF-κB Inhibition Activity of Curcumin-Loaded Sterically Stabilized Micelles and Its Up-Regulator Effect on Enhancement of Cytotoxicity of a New Nano-Pirarubicin Formulation in the Treatment of Breast Cancer

Zahra ESKANDARI
Fatemeh BAHADORİ
MELDA ALTIKATOĞLU YAPAÖZ
Vildan Betul YENİGUN
Abdurrahim KOÇYİĞİT
Hayat ONYUKSEL
Sayfa
390–404
DOI
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Furthermore, we showed that SSM is able to successfully enhance water solubility and therapeutic stability of curcumin for using as a complementary agent.

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Amaç & Hipotez:This study aims to investigate the effects of co-administration of nano-Curcumin on anticancer effect of nano-Pirarubicin considering the fact that the clinical use of Pirarubicin and other anthracyclines has been limited by development of multidrug resistance (MDR) and based on previous data which have shown that Curcumin can down-regulate MDR proteins and suppress the activity of Nuclear factor-kappa B (NF-κB) a protein involved in chemoresistance.
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Temel Bulgular & Veri:Nano micellar formulations of both Curcumin and Pirarubicin were separately synthesized using 1,2-Distearoyl-sn-glycero-3-phosphoethanolamine-N-methoxy-[poly(ethylene glycol); PEG MW 2,000] (DSPE-PEG2000).
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Sonuç & Katkı:Furthermore, we showed that SSM is able to successfully enhance water solubility and therapeutic stability of curcumin for using as a complementary agent.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri

Özet

This study aims to investigate the effects of co-administration of nano-Curcumin on anticancer effect of nano-Pirarubicin considering the fact that the clinical use of Pirarubicin and other anthracyclines has been limited by development of multidrug resistance (MDR) and based on previous data which have shown that Curcumin can down-regulate MDR proteins and suppress the activity of Nuclear factor-kappa B (NF-κB) a protein involved in chemoresistance. Nano micellar formulations of both Curcumin and Pirarubicin were separately synthesized using 1,2-Distearoyl-sn-glycero-3-phosphoethanolamine-N-methoxy-[poly(ethylene glycol); PEG MW 2,000] (DSPE-PEG2000). The produced sterically stabilized micelles (SSM) are very well known drug delivery systems in terms of their enhanced efficacy and good toxicity profile. We measured the differences of NF-κB levels in two different situations: when Pirarubicin is used alone and when it is co-administered with Curcumin. This study showed that co-administration of SSM-Curcumin (CSSM) and SSM-Pirarubicin (PSSM) with size of 12.81 nm enhances the efficacy of Pirarubicin by suppressing P65, an NF-κB subunit. Furthermore, we showed that SSM is able to successfully enhance water solubility and therapeutic stability of curcumin for using as a complementary agent.

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Bu Makaleye Atıf Yap

ESKANDARI, Z., BAHADORİ, F., YAPAÖZ, M. A., YENİGUN, V. B., KOÇYİĞİT, A., ONYUKSEL, H. (2019). NF-κB Inhibition Activity of Curcumin-Loaded Sterically Stabilized Micelles and Its Up-Regulator Effect on Enhancement of Cytotoxicity of a New Nano-Pirarubicin Formulation in the Treatment of Breast Cancer. Records of Natural Products, Cilt: 13 - Sayı: 5, 390–404. https://ajindex.com/articles/308583

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Kaynakça (13)

  1. A. Shehzad, F. Wahid and Y.S. Lee (2010). Curcumin in cancer chemoprevention: Molecular targets, pharmacokinetics, bioavailability, and clinical trials, Arch. Pharm. (Weinheim). 343, 489-499
  2. S. Toden and A. Goel (2017). The holy grail of curcumin and its efficacy in various diseases: Is bioavailability truly a big concern?, J. Restorat. Medic. 6, 27-36
  3. M. López‐Lázaro (2008). Anticancer and carcinogenic properties of curcumin: Considerations for its clinical development as a cancer chemopreventive and chemotherapeutic agent, Mol. Nutr. Food Res. 52, S103-S127
  4. D. Sinha, J. Biswas, B. Sung, B.B. Aggarwal and A. Bishayee (2012). Chemopreventive and chemotherapeutic potential of curcumin in breast cancer, Curr. Drug Targets. 13, 1799-1819
  5. T. Esatbeyoglu, K. Ulbrich, C. Rehberg, S. Rohn and G. Rimbach (2015). Thermal stability, antioxidant, and anti-inflammatory activity of curcumin and its degradation product 4-vinyl guaiacol, Food Funct. 6, 887-893
  6. K. Pan, H. Chen, S.J. Baek and Q. Zhong (2018). Self-assembled curcumin-soluble soybean polysaccharide nanoparticles: Physicochemical properties and in vitro anti-proliferation activity against cancer cells, Food Chem. 246, 82-89
  7. A. Enomoto, K. Miyagawa and J. Yamada (2016). Mechanism of anticarcinogenic properties of curcumin and its application for radio-sensitization and clinical treatment, Hoshas. Seibuts. Kenkyu. 51, 115-126
  8. B.H. Choi, C.G. Kim, Y. Lim, S.Y. Shin and Y.H. Lee (2008). Curcumin down-regulates the multidrugresistance mdr1b gene by inhibiting the pi3k/akt/nfκb pathway, Cancer Lett. 259, 111-118
  9. B.B. Aggarwal (2004). Nuclear factor-κb: The enemy within, Cancer Cell. 6, 203-208
  10. S. Shishodia, H.M. Amin, R. Lai and B.B. Aggarwal (2005). Curcumin (diferuloylmethane) inhibits constitutive nf-kappab activation, induces g1/s arrest, suppresses proliferation, and induces apoptosis in mantle cell lymphoma, Biochem Pharmacol. 70, 700-713
  11. R.J. Anto, T.T. Maliekal and D. Karunagaran (2000). L-929 cells harboring ectopically expressed re1a resist curcumin-induced apoptosis, J. Biol. Chem. 1-23, 10.1074/jbc.C000105200 [12] G.R. Pillai, A.S. Srivastava, T.I. Hassanein, D.P. Chauhan and E. Carrier (2004). Induction of apoptosis in human lung cancer cells by curcumin, Cancer Lett. 208, 163-170
  12. N.D. Perkins (2007). Integrating cell-signalling pathways with nf-κb and ikk function, Nat. Rev.Mol. Cell. Biol. 8, 49-62
  13. S.D. Westerheide, M.W. Mayo, V. Ane