KaydedilenlerDerginizi ekleyin

Dergiler / Records of Natural Products / 2017 / Cilt: 11 - Sayı: 3

A New Trihydroxylated Fatty Acid and Phytoecdysteroids from Rhizomes of Trillium govanianum

Shafiq Ur RAHMAN
Achyut ADHİKARİ
Muhammad ISMAIL
Muhammad Raza SHAH
Muhammad KHURRAM
Itrat ANIS
Farman ALİ
Sayfa
323–334
DOI
—
🏛️Bu makalenin bibliyografik verileri ve tam metin bağlantısı DergiPark üzerinden sağlanmıştır.
DergiPark Kaydı ↗
✨

Yapay Zeka Hızlı Bakış & Çıkarımlar

AI Insight
⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Compound 1 showed significant activity against T. rubrum with 70% inhibition and MIC value of 5 µg/mL, but lack of activity against the other test strains

📌 3 Maddede Bu Makale

🎯
Amaç & Hipotez:A crude hydro-methanolic extract of Trillium govanianum ex D.
📊
Temel Bulgular & Veri:Trichophyton rubrum ATCC 40051, Aspergillus niger ATCC 16888, Candida albicans ATCC 18804, Microsporum canis ATCC 32903 and Fusarium lini ATCC 16888.
💡
Sonuç & Katkı:Compound 1 showed significant activity against T. rubrum with 70% inhibition and MIC value of 5 µg/mL, but lack of activity against the other test strains
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri

Abstract

A crude hydro-methanolic extract of Trillium govanianum ex D. Don (Melanthiaceae,Trilliaceae) rhizomes and its subsequent solvents soluble fractions were tested against different fungal strains i.e. Trichophyton rubrum ATCC 40051, Aspergillus niger ATCC 16888, Candida albicans ATCC 18804, Microsporum canis ATCC 32903 and Fusarium lini ATCC 16888. The hydro-methanolic extract showed significant activity against T. rubrum and M. canis with 80 and 75% inhibitions respectively. Among the fractions, chloroform soluble fraction showed 90% inhibition, with minimum inhibitory concentration (MIC) of 10µg/mL against T. rubrum followed by ethyl acetate, butanol and n-hexane fractions. The bio-activity guided isolation of chloroform soluble fraction leads to a new trihydroxylated fatty acid, named govanic acid (1) along with two known phytoecdysteroids i.e. 20-hydroxyecdysone (2) and 5, 20-dihydroxyecdysone (3). The structures of isolated compounds were elucidated through 1D, 2D-NMR spectroscopic data analysis. All compounds in T. govanianum are reported herein for the first time. Compound 1 showed significant activity against T. rubrum with 70% inhibition and MIC value of 5 µg/mL, but lack of activity against the other test strains

🔖

Bu Makaleye Atıf Yap

RAHMAN, S. U., ADHİKARİ, A., ISMAIL, M., SHAH, M. R., KHURRAM, M., ANIS, I., ALİ, F. (2017). A New Trihydroxylated Fatty Acid and Phytoecdysteroids from Rhizomes of Trillium govanianum. Records of Natural Products, Cilt: 11 - Sayı: 3, 323–334. https://ajindex.com/articles/308354

📄 Tam Metin PDF Okuyucu

📄

PDF görüntüleyici hazırlanıyor...

Kaynakça (13)

  1. S. U. Rahman, M. Ismail, M. Khurram and I. U. HAQ (2015). Pharmacognostic and ethnomedicinal studies on Trillium govanianum, Pak. J. Bot. 47, 187-192
  2. K. M. Khan, L. Nahar, A. Al‐Groshi, A. G. Zavoianu, A. Evans, N. M. Dempster, J. D. Wansi, F. Ismail, A. Mannan and S. D. Sarker (2016). Cytotoxicity of the roots of Trillium govanianum against breast (MCF7), liver (HepG2), lung (A549) and urinary bladder (EJ138) carcinoma cells, Phytother. Res. 30, 1716-1720
  3. S. Rani, J. Rana and P. Rana (2013). Ethnomedicinal plants of Chamba district, Himachal Pradesh, India, J. Med. Plants Res. 7, 3147-3157
  4. A. Mahmood, A. Mahmood and R. N. Malik (2012). Indigenous knowledge of medicinal plants from Leepa valley, Azad Jammu and Kashmir, Pakistan, J. Ethnopharmacol. 143, 338-346
  5. S. Pant and S. Samant (2010). Ethnobotanical observations in the Mornaula reserve forest of Komoun, West Himalaya, India, Ethnobot. Leaflets. 2010, 8
  6. S. ur Rahman, M. Ismail, M. R. Shah, A. Adhikari, I. Anis, M. S. Ahmad and M. Khurram (2015). Govanoside A, a new steroidal saponin from rhizomes of Trillium govanianum, Steroids 104, 270-275
  7. S. ur Rahman, M. Ismail, M. R. Shah, M. Iriti and M. Shahid (2015). GC/MS analysis, free radical scavenging, anticancer and β-glucuronidase inhibitory activities of Trillium govanianum rhizome, Bangladesh J. Pharmacol. 10, 577-583
  8. H. Sood, S. Sharma, A. Sharma, V. Mehta, R. S. Chauhan and U. Malairaman (2016). Efficient hydro alcoholic extraction for highest diosgenin content from Trillium govanianum (nag chhatri) and it’s in vitro anti cancerous activity, Asian J Pharm Clin Res. 9, 386-392
  9. S. Ur Rahman, A. Adhikari, M. Ismail, M. Raza Shah, M. Khurram, M. Shahid, F. Ali, A. Haseeb, F. Akbar and M. Iriti (2016). Beneficial effects of Trillium govanianum rhizomes in pain and inflammation, Molecules 21, 1095
  10. H. Khan, M. Saeed, M. A. Khan, I. Khan, M. Ahmad, N. Muhammad and A. Khan (2012). Antimalarial and free radical scavenging activities of rhizomes of Polygonatum verticillatum supported by isolated metabolites, Med Chem Res. 21, 1278-1282
  11. J.M. Gao, C.-Y. Wang, A.L. Zhang and J.K. Liu (2001). A new trihydroxy fatty acid from the ascomycete, Chinese truffle Tuber indicum, Lipids 36, 1365-1370
  12. D. L. Pavia, G. M. Lampman, G. S. Kriz and J. A. Vyvyan (2008). Introduction to spectroscopy, Cengage Learning, pp 37
  13. S. Perea, A. W. Fothergill, D. A. Sutton and M. G. Rinaldi (2001). Comparison of in vitro ac