A New Pair of Pentaketide Diastereoisomers fromAspergillus melleus YIM PHI001

Amaç & Hipotez:Two new aspinotriol derivatives (1-2) determined as melleusin A (1), B (2) and other seven known compounds were isolated froma soil-borne fungusAspergillus melleus.The configurations of 1, and 2 were determined by theiranalogues,aspilactonol B, Cisolatedprevious inAspergillus.

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Temel Bulgular & Veri:Mellein (8) showed broad antibiotic activity against the test pathogens.

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Sonuç & Katkı:Aspinonene, aspinotriols A and B can be used as the marker molecule in chemotaxonomy of Aspergillus.

🔬Tür:Araştırma Makalesi

📍Kapsam:Genişletilmiş Akademik Örneklem

⚙️Değişkenler:Alan Parametreleri

Özet

Two new aspinotriol derivatives (1-2) determined as melleusin A (1), B (2) and other seven known compounds were isolated froma soil-borne fungusAspergillus melleus.The configurations of 1, and 2 were determined by theiranalogues,aspilactonol B, Cisolatedprevious inAspergillus. Mellein (8) showed broad antibiotic activity against the test pathogens. Aspinonene, aspinotriols A and B can be used as the marker molecule in chemotaxonomy of Aspergillus.

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Bu Makaleye Atıf Yap

WANG, Q., YANG, X., MİAO, C., XU, L., DİNG, Z., YANG, Y., ZHAO, L. (2018). A New Pair of Pentaketide Diastereoisomers fromAspergillus melleus YIM PHI001. Records of Natural Products, Cilt: 12 - Sayı: 3, 216–226. https://ajindex.com/articles/306289

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Kaynakça (9)

H. W. Zhang, Y. F. Tang, C. F. Ruan and X. L. Bai (2016). Bioactive secondary metabolites from the endophytic Aspergillus genus, Rec. Nat. Prod. 10, 1-16.
J. C. Frisvad and T.O. Larsen (2015). Chemodiversity in the genus Aspergillus, Appl. Microbiol. Biotechnol. 99, 7859–7877.
A. M. Hill, A. Jacobs and J. Staunton (1995). Investigation of the stereochemistry of the tri- and tetraketide hydroxyacyl intermediates in the biosynthesis of the polyketide aspyrone in Aspergillus malleus using deuterium labelling and deuterium NMR spectroscopy, J. Chem. Soc. Chem. Commun. 8, 859-860.
H. Zhou, L. X. Zhao, W. Li, Y. B. Yang, L. H. Xu, and Z. T. Ding (2015). Anti-Mycobacterium tuberculosis active metabolites from an endophytic Streptomyces sp. YIM65484, Rec. Nat. Prod. 9, 196-200.
X. W. Chen, C. W. Li, C. B. Cui, W. Hua, T.J. Zhu and Q. Q. Gu (2014) Nine new and five known polyketides derived from a deep sea-sourced Aspergillus sp. 16-02-1, Mar. Drugs 12, 3116-3137.
K. Kito, R. Ookura, S. Yoshida, M. Namikoshi, T. Ooi and T. Kusumi (2007). Pentaketides relating to aspinonene and dihydroaspyrone from a marine-derived fungus, Aspergillus ostianus, J. Nat. Prod. 70, 2022–2025.
Y. Y. Li, P. Liu, Y. Tang, H. M. Li, Y. L. Tang, X. H. Liang and Y. J. Tang (2013). Novel cerebrosides isolated from the fermentation mycelia of Tuber indicum, Helv. Chim. Acta 96, 702-709.
W. Li, X. Q. Yang, Y. B. Yang, S. H. Qin, Q. L. Li, L. X. Zhao and Z. T. Ding (2015). A new natural nucleotide and other antibacterial metabolites from an endophytic Nocardia sp., Nat. Prod. Res. 29, 132– 136. [9] N. Kamal, C. V. Viegelmann, C. J. Clements and R. A. Edrada-Ebel. Metabolomics-guided isolation of antitrypanosomal metabolites from the endophytic fungus Lasiodiplodia theobromae, Planta Med. DOI: 10.1055/s-0042-118601.
C. H. Lu, S. S. Liu, J. Y. Wang, M. Z. Wang and Y. M. Shen (2014). Characterization of eight new secondary metabolites from the mutant strain G-444 of Tubercularia sp. TF5, Helv. Chim. Acta, 97, 334- 344.