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Dergiler / Marmara Medical Journal / 2002 / Cilt: 15 - Sayı: 4

THE RELATION BETWEEN HUMAN Y CHROMOSOME MICRODELETIONS AND SPERM MORPHOLOGY

Deniz SEVİNÇ
Ahmet ZEHİR
Anıl BİRİCİK
Semra SERTYEL
Semra KAHRAMAN
AHMET İLTER GÜNEY
Sayfa
227–232
DOI
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Yapay Zeka Hızlı Bakış & Çıkarımlar

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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

It is suggested thata detailed sperm morphology examination andclassification is needed to clarify the Ychromosome deletion-sperm morphology relation.Key Words: Y chromosome microdeletions,Sperm morphology, Male infertility

📌 3 Maddede Bu Makale

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Amaç & Hipotez:O b je c tiv e : Recent investigations havesupported the importance of Y chromosomemicrodeletions in male infertility.
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Temel Bulgular & Veri:The aim of our study wasto understand the relation between Ychromosome microdeletions and spermmorphology in different risk groups.Material and Methods: In this study, 34 infertilemen were selected and examined in terms ofsperm morphology and Y chromosomemicrodeletions.
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Sonuç & Katkı:It is suggested thata detailed sperm morphology examination andclassification is needed to clarify the Ychromosome deletion-sperm morphology relation.Key Words: Y chromosome microdeletions,Sperm morphology, Male infertility
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri

Abstract

O b je c tiv e : Recent investigations havesupported the importance of Y chromosomemicrodeletions in male infertility. Besidesdifferent factors, sperm morphology is also a veryimportant component of the clinical evaluation ofmale fertility potential. The aim of our study wasto understand the relation between Ychromosome microdeletions and spermmorphology in different risk groups.Material and Methods: In this study, 34 infertilemen were selected and examined in terms ofsperm morphology and Y chromosomemicrodeletions. Semen analyses of the patientswere performed by using Strict criteria and thesamples were grouped according to the spermabnormalities. Peripheral blood samples wereexamined for Y chromosome microdeletions by amultiplex polymerase chain reaction amplificationof sequence-tagged sites (STS) of the Ychromosome.R e su lts : The incidence of deletions in the groupwas 14.7 % (5/34). The rates of Y chromosomemicrodeletion were 33.3% for megalohead,33.3% for elongehead, 0% for roundhead, 100%for pinhead, 14.3% for severe teratozoospermia,33.3% for severe neck abnormalities and 0% fortail-stump Pregnancy could not be obtained fromY chromosome deleted cases.Co nclus io n: It seems that especially patientswith sperm head and neck abnormality haveincreased microdeletion risk. It is suggested thata detailed sperm morphology examination andclassification is needed to clarify the Ychromosome deletion-sperm morphology relation.Key Words: Y chromosome microdeletions,Sperm morphology, Male infertility

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Bu Makaleye Atıf Yap

SEVİNÇ, D., ZEHİR, A., BİRİCİK, A., SERTYEL, S., KAHRAMAN, S., GÜNEY, A. İ. (2002). THE RELATION BETWEEN HUMAN Y CHROMOSOME MICRODELETIONS AND SPERM MORPHOLOGY. Marmara Medical Journal, Cilt: 15 - Sayı: 4, 227–232. https://ajindex.com/articles/284398

Kaynakça (10)

  1. Hartung M, Devictor M, Codaccioni JL. Yq deletion and failure of spermatogenesis. Ann Genet 1998; 31: 21-26.
  2. Robayashi K, Mizuno R, llida A. PCR analysis of the Y chromosome long arm in azoospermic patients: evidence for a second locus required for spermatogenesis. Hum Mol Genet 1994; 3: 1965-1967.
  3. Reijo R, Lee T, Salo P, et at. Diverse spermatogenic defects in humans caused by Y chromosome deletions encompassing a novel RHA-binding protein gene, nature Genet 1995; 10: 383-393. The PSHRE Capri Workshop Group. Male infertility update. Plum Reprod 1998; 13: 2025-2032.
  4. Bardoni B, Zuffardi O, Guioli S. A deletion map of the human Yq 11 region: Implications for the evolution of the Y chromosome and tentative mapping of a locus involved in spermatogenesis. Genomics 1991; II: 443- 451. Chandley AC, Cooke fiJ. Human male infertility - Y linked genes and spermatogenesis. Hum Mol Genet 1994; 3: 1449-1452.
  5. Tiepolo L, Zuffardi O. Localization of factors controlling spermatogenesis in the non fluorescent portion of the human Y chromosome long arm. Hum Genet I976;34: I 19-124. Pitch T1, Richer CL, Pinsky L. Deletion of the long arm of the Y chromosome and review of 3 0 Y chromosome microdeletions and sperm morphology the Y chromosome abnormalities. Am J Med Genet 1985; 20: 31-42.
  6. Andersson M, Page DC, Pettay D. Y chromosome translocations and mosaicism in the aetiology of 45,X maleness: Assignment of fertility to factor to distal Yq 11. Hum Genet 1988; 79: 2-7.
  7. Johnson MD, Tho SPT, Behzadian A. Molecular scanning of Yq 11 (interval 6) in men with sertoli cell-only syndrome. Am J Obstet Gynecol 1989; 161: 1732-1737.
  8. I. Share J, Drwinga tl, Wyandt II. Interstitial deletion involving most of Yq. Am J Med Genet 1990; 36: 394-397. !2. Ma b, Sharkey A, birsch S. Towards the molecular localisation of the AZP locus: mapping of microdeletions in azoospermic men within 14 subintervals of interval 6 of the human Y chromosome. Hum Mol Genet 1992; 1: 29-33.
  9. Ma b, Inglis JD, Sharkey A. A chromsome gene family with KHA-binding protein homology: candidates for the azoospermia factor AZF controlling human spermatogenesis. Cell 1993; 75: 1287-1295.
  10. Vogt PH, Chandley AC, Hargreave TB. Microdeletions in interval 6 of the Y chromosome of males with idiopathic sterility point to disruption of AZF, a human spermatogenesis. Hum Genet 1992; 89: 491 - 496. Foresta C, Ferlin A, Garolla A. High frequency of well-defined Y chromosome deletions in idiopathic sertoli cell only syndrome. Hum Keprod 1