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Dergiler / Marmara Pharmaceutical Journal / 2017 / Cilt: 21 - Sayı: 3

3D quantitatve structure activity relationship of tetrahydroimidazo [1,2-a] pyrimidine as antimicrobial agents

Shivangi HARANKHEDKAR
Sayfa
644–653
DOI
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

QSAR models revealed positive influence of steric and electronic parameters on antimicrobial potential - of tetrahydroimidazo[1,2-a] pyrimidine derivatives.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:A series 24 tetrahydroimidazo[1,2-a] pyrimidine derivatives were subjected to 3D quantitative structure activity relationship for antimicrobial activity.
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Temel Bulgular & Veri:Six different QSAR models have been generated for antimicrobial efficiency of tetrahydroimidazo[1,2-a] pyrimidine derivatives against three human pathogens.
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Sonuç & Katkı:QSAR models revealed positive influence of steric and electronic parameters on antimicrobial potential - of tetrahydroimidazo[1,2-a] pyrimidine derivatives.
🔬Tür:Modelleme & Sayısal Simülasyon
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri

Özet

A series 24 tetrahydroimidazo[1,2-a] pyrimidine derivatives were subjected to 3D quantitative structure activity relationship for antimicrobial activity. Partial least square methodology was utilized for the development of QSAR models. Six different QSAR models have been generated for antimicrobial efficiency of tetrahydroimidazo[1,2-a] pyrimidine derivatives against three human pathogens. QSAR models revealed positive influence of steric and electronic parameters on antimicrobial potential - of tetrahydroimidazo[1,2-a] pyrimidine derivatives.

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Bu Makaleye Atıf Yap

HARANKHEDKAR, S. (2017). 3D quantitatve structure activity relationship of tetrahydroimidazo [1,2-a] pyrimidine as antimicrobial agents. Marmara Pharmaceutical Journal, Cilt: 21 - Sayı: 3, 644–653. https://ajindex.com/articles/283684

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Kaynakça (13)

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