Compound 1a exhibited anti-LPO and DPPH˙ scavenging activities at concentrations lower than those cytotoxic for mouse normal fibroblast (NIH/3T3) cells and was also found to be slightly more selective for cancer cells (human prostat adenocarcinoma cell/PC-3) than normal mammalian cells.
📌 3 Maddede Bu Makale
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Amaç & Hipotez:In this work, we report the synthesis, structural characterization and evaluation of in vitro antioxidant and cytotoxic properties of novel spirobenzothiazolines (1a-e, 2a-e). 5-nonsubstituted spirobenzothiazolines (1a-e) demonstrated notable inhibitory capacity on lipid peroxidation (LPO), reducing power and scavinging effects on diphenylpicryl hydrazine (DPPH˙) and 2,2’-azino-bis(3-ethylbenzthiazoline-6-sulphonic acid (ABTS˙+) radicals, that were similar to that of α-tocopherol.
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Temel Bulgular & Veri:The most potent antioxidant was compound 1a (incorporating an ethyl group on the cyclohexane ring) with an anti-LPO activity 2-fold higher than that of α-tocopherol.
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Sonuç & Katkı:Compound 1a exhibited anti-LPO and DPPH˙ scavenging activities at concentrations lower than those cytotoxic for mouse normal fibroblast (NIH/3T3) cells and was also found to be slightly more selective for cancer cells (human prostat adenocarcinoma cell/PC-3) than normal mammalian cells.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri
Özet
In this work, we report the synthesis, structural characterization and evaluation of in vitro antioxidant and cytotoxic properties of novel spirobenzothiazolines (1a-e, 2a-e). 5-nonsubstituted spirobenzothiazolines (1a-e) demonstrated notable inhibitory capacity on lipid peroxidation (LPO), reducing power and scavinging effects on diphenylpicryl hydrazine (DPPH˙) and 2,2’-azino-bis(3-ethylbenzthiazoline-6-sulphonic acid (ABTS˙+) radicals, that were similar to that of α-tocopherol. The most potent antioxidant was compound 1a (incorporating an ethyl group on the cyclohexane ring) with an anti-LPO activity 2-fold higher than that of α-tocopherol. Compound 1a exhibited anti-LPO and DPPH˙ scavenging activities at concentrations lower than those cytotoxic for mouse normal fibroblast (NIH/3T3) cells and was also found to be slightly more selective for cancer cells (human prostat adenocarcinoma cell/PC-3) than normal mammalian cells.
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Bu Makaleye Atıf Yap
ÜSTÜNDAĞ, G. C., ÖZSOY, N., ÖZTAŞ, E., KARALI, N. L., ÇAPAN, G. (2017). Antioxidant and cytotoxic properties of novel spirocyclic benzothiazolines. Marmara Pharmaceutical Journal, Cilt: 21 - Sayı: 4, 978–986. https://ajindex.com/articles/283655
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