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Dergiler / Marmara Pharmaceutical Journal / 2017 / Cilt: 21 - Sayı: 2

Synthesis and Antimicrobial Activity of Some Taurinamide Derivatives

ÖZLEM AKGÜL
İSMAİL ÖZTÜRK
ABDURRAHMAN AYGÜL
ŞAFAK ERMERTCAN
Sayfa
361–370
DOI
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Among the tested compounds, para substituted methyl and methoxy derivatives of N-phenyl-2- phthalimidotaurinamide (4, 7), displayed equipotent activity compared to standard drug gentamicin.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:In this study, a series of taurinamide derivatives were synthesized and screened for their antimicrobial activity.
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Temel Bulgular & Veri:The structures of the newly synthesized compounds 11-15 were evaluated by 1 H NMR, IR, MS-APCI and elemental analysis.
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Sonuç & Katkı:Among the tested compounds, para substituted methyl and methoxy derivatives of N-phenyl-2- phthalimidotaurinamide (4, 7), displayed equipotent activity compared to standard drug gentamicin.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri

Özet

In this study, a series of taurinamide derivatives were synthesized and screened for their antimicrobial activity. The structures of the newly synthesized compounds 11-15 were evaluated by 1 H NMR, IR, MS-APCI and elemental analysis. Compounds (1-15) were tested against standard strains of Gram(+), Gram(−) bacteria and fungi by using disc diffusion and broth microdilution methods. Although disc diffusion method did not show any comparable results due to the solubility properties of the compounds; microdilution method results indicated that title compounds showed from poor to good activity against only Enterococcus faecalis. It can be concluded that phtalimido moiety, secondary aryl sulphonamide group and electron- donating group substitution on phenyl ring are essential for the antibacterial activity. Among the tested compounds, para substituted methyl and methoxy derivatives of N-phenyl-2- phthalimidotaurinamide (4, 7), displayed equipotent activity compared to standard drug gentamicin.

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Bu Makaleye Atıf Yap

AKGÜL, Ö., ÖZTÜRK, İ., AYGÜL, A., ERMERTCAN, Ş. (2017). Synthesis and Antimicrobial Activity of Some Taurinamide Derivatives. Marmara Pharmaceutical Journal, Cilt: 21 - Sayı: 2, 361–370. https://ajindex.com/articles/283628

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Kaynakça (12)

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