Dergiler / Medeniyet Medical Journal / 2017 / Cilt: 32 - Sayı: 2

The effects of dexamethasone vs low doses of propofol infusion on postoperative nausea and vomiting in tympanoplasty surgery: A randomized, placebo-controlled, double-blinded study

Timpanoplasti cerrahisinde postoperatif bulantı ve kusmaya deksametazon ile düşük doz propofol infüzyonunun etkilerinin karşılaştırılması: Randomize, plasebo-kontrollü, çift kör çalışma

Sayfa
85–90
DOI
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Intraoperative low-dose propofol infusion is as effective as dexamethasone in reducing the incidence and se- verity of postoperative nausea and vomiting, as well as reducing post-tympanoplasty antiemetic requirements.

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Amaç & Hipotez:This prospective study investigated the effects of dexamethaso- ne and low-dose propofol infusion on postoperative nausea and vomiting in 90 patients undergoing tympanoplasty.
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Temel Bulgular & Veri:The dexa- methasone group (Group D) received 8 mg dexamethasone and the control group (Group C) 2 ml saline 15 min before the end of surgery, while the propofol group (Group P) received ıntrave- nous propofol infusion at a dose of 20 mcg/kg/min throughout surgery following induction of anaesthesia.
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Sonuç & Katkı:Intraoperative low-dose propofol infusion is as effective as dexamethasone in reducing the incidence and se- verity of postoperative nausea and vomiting, as well as reducing post-tympanoplasty antiemetic requirements.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri

Özet

This prospective study investigated the effects of dexamethaso- ne and low-dose propofol infusion on postoperative nausea and vomiting in 90 patients undergoing tympanoplasty. The dexa- methasone group (Group D) received 8 mg dexamethasone and the control group (Group C) 2 ml saline 15 min before the end of surgery, while the propofol group (Group P) received ıntrave- nous propofol infusion at a dose of 20 mcg/kg/min throughout surgery following induction of anaesthesia. Incidence rates and severity of nausea-vomiting and antiemetic requirements were recorded throughout the first postoperative 24 hours. Between hours 0 and 2, any incidence of postoperative nausea and vo- miting was not observed in 23 (76.7%) patients in Group P, 17 (56.7%) in Group D and 8 (26.7%) in Group C. Differences were observed between the groups in hours 0-2 and 2-8 in terms of verbal descriptive scale values for postoperative nausea and vo- miting (p<0.01 and p=0.004, respectively). Total incidence rates of postoperative nausea and vomiting at hours 2-8 h were 10.0% (n=3) in Group P, 36.7% (n=11) in Group D and 53.3% (n=16) in Group C, the difference being statistically significant in favour of Group P (p=0.032). At 0-24. hrs, the number of patients vomiting, despite treatment, were lower in Groups P and D (n=4, 13.3% and n=5, 16.7%, respectively) compared to Group C (n=14, 46.7%) (p=0.005). Antiemetic use was higher in Group C than in Groups D and P (p=0.001). Intraoperative low-dose propofol infusion is as effective as dexamethasone in reducing the incidence and se- verity of postoperative nausea and vomiting, as well as reducing post-tympanoplasty antiemetic requirements.

Abstract

Bu prospektif çalışmayla, timpanoplasti uygulanan 90 hastada postoperatif bulantı ve kusma üzerine deksametazon ve düşük doz propofol infüzyonunun etkileri araştırıldı. Ameliyat bitimin- den 15 dk. önce deksametazon grubuna (Grup D) 8 mg deksame- tazon ve kontrol grubuna (Grup C) 2 ml salin yapılırken, propofol grubuna (Grup P), anestezi indüksiyonu sonrasında ameliyat bo- yunca 20 mcg/kg/dk. propofol intravenöz infüzyonu yapılmıştır. Postoperatif ilk 24 saat boyunca bulantı-kusma ve antiemetik gereksinimlerinin insidans ve şiddeti kaydedildi. Sıfır-iki saatlik periyotta, Grup P’de 23 (%76,7) hastada, Grup D’de 17 (%56,7) ve Grup C’de 8 hastada (%26,7) postoperatif bulantı ve kusma görülmedi. Gruplar arasında postoperatif bulantı ve kusma için sözel tanımlayıcı ölçek değerleri açısından 0-2 ve 2-8 saatlik sü- reler arasında farklar gözlemlendi (sırasıyla p<0,01 ve p=0,004). 2-8 saatlik postoperatif bulantı ve kusma sıklığı Grup P’de %10,0 (n=3), Grup D’de %36,7 (n=11) ve Grup C’de %53,3 (n=16) idi, bu fark Grup P lehine istatistiksel olarak anlamlıydı (p=0,032). Sıfır- yirmi dört saatte tedaviye rağmen, kusma sayısı grup C’ye kıyas- la Grup P ve Grup D’de (sırasıyla n=4, %13,3 ve n=5, %16,7) daha düşüktü (n=14, %46,7) (P=0,005). Antiemetik kullanımı, Grup C’de Grup D ve P’ye göre daha yüksekti (p=0,001). İntraopera- tif düşük doz propofol infüzyonu, postoperatif bulantı ve kusma sıklığını ve şiddetini azaltmada aynı zamanda timpanoplastiden sonra bir antiemetik kullanım gereksinimini azaltmada deksame- tazon kadar etkilidir.

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Bu Makaleye Atıf Yap

ÖZMEN, Ö., BİNGÖL, F., ARSLAN, Z., BİNGÖL, B. Ö. (2017). The effects of dexamethasone vs low doses of propofol infusion on postoperative nausea and vomiting in tympanoplasty surgery: A randomized, placebo-controlled, double-blinded study. Medeniyet Medical Journal, Cilt: 32 - Sayı: 2, 85–90. https://ajindex.com/articles/283435

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Kaynakça (11)

  1. Scuderi PE. Pharmacology of antiemetics. Int Anesthesiol Clin 2003;41:41-66. https://doi.org/10.1097/00004311-200341040-00006
  2. Watcha MF, White PF. Postoperative nausea and vomiting. Its etiology, treatment, and prevention. Anesthesiology 1992;77:162-84. https://doi.org/10.1097/00000542-199207000-00023
  3. Camu F, Lauwers MH, Verbessem D. Incidence and aetiology of postoperative nausea and vomiting. Eur J Anaesthesiol Suppl 1992;6:25-31. Barash PG. Management of Anaesthesiaed. Clinical Anesthe- sia. t. Edition. 2006, Lippincott Williams&Wilkins. 1238-40.
  4. Fujii Y, Tanaka H, Kobayashi N. Prevention of postoperative nausea and vomiting with antiemetics in patients undergo- ing middle ear surgery: comparison of a small dose of pro- pofol with droperidol or metoclopramide. Arch Otolaryngol Head Neck Surg 2001;127:25-8. https://doi.org/10.1001/archotol.127.1.25
  5. Lee DW, Lee H G, Jeong CY, at al. Postoperative nausea and vomiting after mastoidectomy with tympanoplasty: a com- parison between TIVA with propofol-remifentanil and ba- lanced anesthesia with sevoflurane-remifentanil. Korean J Anesthesiol 2011;61:399-404. https://doi.org/10.4097/kjae.2011.61.5.399
  6. Fujii Y, Toyooka H, Tanaka H. Granisetron in the prevention of nausea and vomiting after middle-ear surgery: a dose- ranging study. Br J Anaesth 1998;80(6):764-6. https://doi.org/10.1093/bja/80.6.764
  7. Jung JS, Park JS, Kim SO, et al. Prophylactic antiemetic effect of midazolam after middle ear surgery. Otolaryngol Head Neck Surg 2007;137:753-6. https://doi.org/10.1016/j.otohns.2007.07.024
  8. Karlidag T, Kaygusuz İ, Bestas A, et al. The efficacy of droperi- dol, metoclopramide, propofol, and ondansetron for the pre- vention of nausea and vomiting following middle ear surgery. Kulak Burun Bogaz Ihtis Derg 2002;9:331-6.
  9. Celik M, Dostbil A, Aksoy M, et al. Is infusion of subhypno- tic propofol as effective as dexamethasone in prevention of postoperative nausea and vomiting related to laparoscopic cholecystectomy? A randomized controlled trial. Biomed Res Int 2015;2015:349806. https://doi.org/10.1155/2015/349806
  10. Erdem AF, Yoruk O, Alıcı HA, et al. Subhypnotic propofol in- fusion plus dexamethasone is more effective than dexamet- hasone alone for the prevention of vomiting in children after tonsillectomy. Paediatr Anaesth 2008;18:878-83. https://doi.org/10.1111/j.1460-9592.2008.02675.x
  11. Soppitt AJ, Glass PSA, Howell S, at al. The use of propofol for its antiemetic effect: a survey of clinical practice in the United States. J