KaydedilenlerDerginizi ekleyin

Dergiler / Medicine Science / 2020 / Cilt: 9 - Sayı: 3

Histopathological features of chronic hepatitis B reactivation

Remzi BEŞTAŞ
Kendal YALÇIN
Sayfa
721–726
DOI
—
🏛️Bu makalenin bibliyografik verileri ve tam metin bağlantısı DergiPark üzerinden sağlanmıştır.
DergiPark Kaydı ↗
✨

Yapay Zeka Hızlı Bakış & Çıkarımlar

AI Insight
⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

The findings of this study showed that there are significant correlation between histopathologic changes (grade and total HAI score) in liver biopsy and plasma ALT, AST and Total bilirubin levels during acute hepatic exacerbation in patients with chronic hepatitis B infection.

📌 3 Maddede Bu Makale

🎯
Amaç & Hipotez:It was aimed to investigate histopathological changes in acute hepatic exacerbations.
📊
Temel Bulgular & Veri:A total of 20 patients, who developed acute hepatic exacerbation on the base of chronic hepatitis B infection, were enrolled in the study and liver biopsy was performed.
💡
Sonuç & Katkı:The findings of this study showed that there are significant correlation between histopathologic changes (grade and total HAI score) in liver biopsy and plasma ALT, AST and Total bilirubin levels during acute hepatic exacerbation in patients with chronic hepatitis B infection.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri

Özet

It was aimed to investigate histopathological changes in acute hepatic exacerbations. A total of 20 patients, who developed acute hepatic exacerbation on the base of chronic hepatitis B infection, were enrolled in the study and liver biopsy was performed. Histological activity index (HAI) and its components, fibrosis scores and total HAI score were calculated according to the Ishak scoring system. All of the patients enrolled in the study had portal inflammation and spotty necrosis. Fibrosis was present in 17 patients. The median grade, stage and total HAI scores of the patients were 7 (2-14), 2 (0-3) and 8.5 (4-16), respectively. Positive correlation was determined between necroinflammation and ALT. While grade and total HAI score did not show significant difference among genders, fibrosis was significantly higher in males (p=0.008). The findings of this study showed that there are significant correlation between histopathologic changes (grade and total HAI score) in liver biopsy and plasma ALT, AST and Total bilirubin levels during acute hepatic exacerbation in patients with chronic hepatitis B infection.

🔖

Bu Makaleye Atıf Yap

BEŞTAŞ, R., YALÇIN, K. (2020). Histopathological features of chronic hepatitis B reactivation. Medicine Science, Cilt: 9 - Sayı: 3, 721–726. https://ajindex.com/articles/277098

📄 Tam Metin PDF Okuyucu

📄

PDF görüntüleyici hazırlanıyor...

Kaynakça (17)

  1. Chang ML, Liaw YF. Hepatitis B flares in chronic hepatitis B: Pathogenesis, natural course, and management. J Hepatol. 2014;6:1407–17
  2. Feldman M, Friedman LS, Brandt LJ. Acute flares in chronic hepatitis B. Sleisenger and Fordtran’s gastrointestinal and liver disease - pathophysiology, diagnosis, management, 9th edition volume (2). Saunders Elsevier. 2010;1297-8
  3. Yalcın K, Degertekin H, Bahcecioglu IH et al. Hepatitis B virus genotype D prevails in patients with persistently elevated or normal ALT levels in Turkey. Infection. 2004;32:24-9
  4. Liaw YF. Hepatitis flares and hepatitis B e antigen seroconversion: Implication in anti-hepatitis B virus therapy. J Gastroenterol Hepatol. 2003;18:246–52
  5. Mori S, Fujiyama S. Hepatitis B virus reactivation associated with antirheumatic therapy: Risk and prophylaxis recommendations. World J Gastroenterol. 2015;21:10274-89
  6. Mani H, Kleiner DE. Liver biopsy findings in chronic Hepatitis B. Hepatol. 2009;49:61-71
  7. Ott JJ, Stevens GA, Groeger J, et al. Global epidemiology of hepatitis B virus infection: new estimates of age-specific HBsAg seroprevalence and endemicity. Vaccine. 2012;30:2212–9
  8. Lok AS, Bonis P. Hepatitis B virus reactivation associated with immunosuppression. http://.uptodate.com Last literature review version 19.05.2011
  9. Singhal A, Kanagala R, Jalil S et al. Chronic HBV with pregnancy: Reactivation flare causing fulminant hepatic failure. Ann Hepatol. 2011;10: 233-6
  10. Huang YH, Lin HC, Lee SD. Management of chemotherapy-induced hepatitis B virus reactivation. J Chin Med Assoc. 2012;75:359-62
  11. Shouval D, Shibolet O. Immunosuppression and HBV reactivation. Semin Liver Dis. 2013;33:167–77
  12. Liaw YF, Chu CM. Hepatitis B virus infection. Lancet. 2009;373:582–92
  13. Liaw YF, Chu CM, Su IJ, et al. Clinical and histological events preceding hepatitis B e antigen seroconversion in chronic type B hepatitis. Gastroenterol. 1983;84:216–9
  14. Lok AS, Lai CL. Acute exacerbations in Chinese patients with chronic hepatitis B virus (HBV) infection. Incidence, predisposing factors and etiology. J Hepatol. 1990;10:29–34
  15. Liaw YF, Yang SS, Chen TJ, et al. Acute exacerbation in hepatitis B e antigenpositive chronic type B hepatitis: a clinicopathological study. J Hepatol. 1985;1:227–33
  16. Liaw YF, Tai DI, Chu CM, et al. Acute exacerbation in chronic type B hepatitis: comparison between HBeAg and antibody positive patients. Hepatol. 1987;7:20– 3
  17. Hsu YS, Chien RN, Yeh CT, et al. Lo