Dergiler / Medicine Science / 2021 / Cilt: 10 - Sayı: 1

Effects of sugammadex on platelet levels and platelet-to-lymphocyte ratio in morbidly obese patients undergoing sleeve gastrectomy

Sayfa
106–110
DOI
—
🏛️Bu makalenin bibliyografik verileri ve tam metin bağlantısı DergiPark üzerinden sağlanmıştır.
DergiPark Kaydı ↗
✨

Yapay Zeka Hızlı Bakış & Çıkarımlar

AI Insight
⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

None of the morbidly obese patients, who were administrated sugammadexn (2 mg kg-1) via intravenous administration, underwent reoperation in the postoperative period due to coagulopathy.

📌 3 Maddede Bu Makale

🎯
Amaç & Hipotez:Sugammadex is known to have minimal effects on coagulopathy.
📊
Temel Bulgular & Veri:This retrospective study included a total of 86 morbidly obese patients with a Body Mass Index (BMI) of >40 kg/m2 and with an American Society of Anaesthesiologists Classification score (ASA) III undergoing elective laparoscopic sleeve gastrectomy (LSG).
💡
Sonuç & Katkı:None of the morbidly obese patients, who were administrated sugammadexn (2 mg kg-1) via intravenous administration, underwent reoperation in the postoperative period due to coagulopathy.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri

Özet

Sugammadex is known to have minimal effects on coagulopathy. The aim of this study was to analyse the changes in platelet levels and platelet-to-lymphocyte ratio (PLR) in preoperative and postoperative periods in morbidly obese patients. This retrospective study included a total of 86 morbidly obese patients with a Body Mass Index (BMI) of >40 kg/m2 and with an American Society of Anaesthesiologists Classification score (ASA) III undergoing elective laparoscopic sleeve gastrectomy (LSG). Patient data were obtained from patient files and electronic health records system (SARUS). The patients were allocated into two groups namely sugammadex (Group S) and neostigmine (Group N). Preoperative and postoperative (12th hour) hemogram recordings of the patients were examined. Compared to preoperative levels, there was a significant decrease in the postoperative platelet and lymphocyte values of patients in Group S (p 0.05). Although sugammadex causes a decrease in the platelet and lymphocyte levels in the postoperative period similar to neostigmine, a relatively higher decrease in lymphocyte levels caused an increase in PLR values. None of the morbidly obese patients, who were administrated sugammadexn (2 mg kg-1) via intravenous administration, underwent reoperation in the postoperative period due to coagulopathy.

🔖

Bu Makaleye Atıf Yap

GÖRGÜLÜ, Ö., KOŞAR, M. N. (2021). Effects of sugammadex on platelet levels and platelet-to-lymphocyte ratio in morbidly obese patients undergoing sleeve gastrectomy. Medicine Science, Cilt: 10 - Sayı: 1, 106–110. https://ajindex.com/articles/276724

📄 Tam Metin PDF Okuyucu

📄

PDF görüntüleyici hazırlanıyor...

Kaynakça (13)

  1. Hawkins J, Khanna S, Argalious M. Sugammadex for Reversal of neuromuscular blockade: uses and limitations. Curr Pharm Des. 2019;25:2140-8
  2. Saokham P, Loftsson T. γ-Cyclodextrin. Int J Pharm. 2017;516:278-92
  3. Guo X, Sun T, Zhong R et al. Effects of chitosan oligosaccharides on human blood components. Front Pharmacol. 2018;9:1412
  4. Lee IO, Kim YS, Chang HW et al. In vitro investigation of the effects of exogenous sugammadex on coagulation in orthopedic surgical patients. BMC Anesthesiol. 2018;18:56 5. Carron M, Bertini D, Prandini T et al. Effect of sugammadex on coagulation as detected by rotational thromboelastometry in morbidly obese patients. Minerva Anestesiol. 2018;84:178-88
  5. Zhang J, Feng W, Ye Z et al. Prognostic significance of platelet-tolymphocyte ratio in patients with nasopharyngeal carcinoma: a metaanalysis. Future Oncol. 2019 7. Bao Y, Wang Y, Li X et al. Prognostic significance of platelet-to-lymphocyte ratio in urothelial carcinoma patients: a meta-analysis. Cancer Cell Int. 2019;19:315
  6. Shen XB, Wang Y, Shan BJ et al. Prognostic significance of platelet-tolymphocyte ratio (plr) and mean platelet volume (mpv) during etoposidebased first-line treatment in small cell lung cancer patients. Cancer Manag Res. 2019;11:8965-75
  7. Zhong B, Gu DY, Du JT et al. Correction: May the change of platelet to lymphocyte ratio be a prognostic factor for T3-T4 laryngeal squamous cell carcinoma: A retrospective study. PLoS One. 2019;14:0226383
  8. Lin WF, Zhong MF, Zhang YR et al. Prognostic role of platelet-tolymphocyte ratio in hepatocellular carcinoma with different BCLC stages: a systematic review and meta-analysis. Gastroenterol Res Pract. 2018;2018:5670949
  9. Moon YJ, Kim SH, Kim JW et al. Comparison of postoperative coagulation profiles and outcome for sugammadex versus pyridostigmine in 992 living donors after living-donor hepatectomy. Medicine (Baltimore). 2018;97:0129
  10. Raft J, Betala Belinga JF, Jurkolow G et al. Clinical evaluation of postsurgical bleeding after a sugammadex injection. Ann Fr Anesth Reanim. 2011;30:714-7
  11. Kitamura T, Ohno N, Bougaki M et al. [Comparison of the effects of sevoflurane and propofol on changes in leukocyte-count induced by surgical stress]. Masui. 2008;57:968-72
  12. Davenport L, Letson HL, Dobson GP. Immune-inflammatory activation after a single laparotomy in a rat model: effect of adenosine, lidocaine and Mg2+ infusion to dampen the stress response. Innate Immun. 2017;23:482 94
  13. Türkan