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Dergiler / Turkish Journal of Medical Sciences / 2014 / Cilt: 44 - Sayı: 3

Diastolic function of the right ventricle is impaired in experimental type 2 diabetic rat models

Ya MIAO
Wei ZHANG
Yuan ZHONG
Ming ZHONG
Xiao MA
Sayfa
448–453
Yayın Tarihi
2014-05-18
DOI
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TDI showed a high sensitivity in detecting changes of RV diastolic function.

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Amaç & Hipotez:To evaluate diastolic function alterations of the right ventricle (RV) by echocardiography in type 2 diabetic rat models.
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Temel Bulgular & Veri:Materials and methods: Male Wistar rats were divided into 2 groups: a control group (n = 8) and a diabetic group (n = 16, with 11 remaining at the end of the experiment), which was fed a high-fat and high-calorie diet and injected with streptozotocin (STZ).
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Sonuç & Katkı:TDI showed a high sensitivity in detecting changes of RV diastolic function.
🔬Tür:Modelleme & Sayısal Simülasyon
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Key words: Right ventricle · diastolic function · diabetic cardiomyopathy

Özet

To evaluate diastolic function alterations of the right ventricle (RV) by echocardiography in type 2 diabetic rat models. Materials and methods: Male Wistar rats were divided into 2 groups: a control group (n = 8) and a diabetic group (n = 16, with 11 remaining at the end of the experiment), which was fed a high-fat and high-calorie diet and injected with streptozotocin (STZ). RV diastolic functional alteration of rat models was studied by the tricuspid flow Doppler (Ep, Ap, and Ep/Ap) and tissue Doppler imaging (TDI) (Em, Am, and Em/Am) of the lateral tricuspid annulus. RV structural alteration of rat models was studied by standard 2D and M-mode echocardiography. Results: Compared with the control group rats, at the 12th week after STZ injection, the rats of the diabetic group developed RV diastolic dysfunction, lower Em, and lower ratios (Ep/Ap, Em/Am). At the end of the experiment, at the 16th week after STZ injection, the rats of the diabetic group showed further decreased Ep, Em, and ratios (Ep/Ap, Em/Am) and significantly higher RV diameters compared with the control group rats. Conclusion: We demonstrated that the diastolic dysfunction of the RV was the earliest complication observed in type 2 diabetic rat models, using TDI and tricuspid flow Doppler. TDI showed a high sensitivity in detecting changes of RV diastolic function.

Abstract

To evaluate diastolic function alterations of the right ventricle (RV) by echocardiography in type 2 diabetic rat models. Materials and methods: Male Wistar rats were divided into 2 groups: a control group (n = 8) and a diabetic group (n = 16, with 11 remaining at the end of the experiment), which was fed a high-fat and high-calorie diet and injected with streptozotocin (STZ). RV diastolic functional alteration of rat models was studied by the tricuspid flow Doppler (Ep, Ap, and Ep/Ap) and tissue Doppler imaging (TDI) (Em, Am, and Em/Am) of the lateral tricuspid annulus. RV structural alteration of rat models was studied by standard 2D and M-mode echocardiography. Results: Compared with the control group rats, at the 12th week after STZ injection, the rats of the diabetic group developed RV diastolic dysfunction, lower Em, and lower ratios (Ep/Ap, Em/Am). At the end of the experiment, at the 16th week after STZ injection, the rats of the diabetic group showed further decreased Ep, Em, and ratios (Ep/Ap, Em/Am) and significantly higher RV diameters compared with the control group rats. Conclusion: We demonstrated that the diastolic dysfunction of the RV was the earliest complication observed in type 2 diabetic rat models, using TDI and tricuspid flow Doppler. TDI showed a high sensitivity in detecting changes of RV diastolic function.

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Bu Makaleye Atıf Yap

MIAO, Y., ZHANG, W., ZHONG, Y., ZHONG, M., MA, X. (2014). Diastolic function of the right ventricle is impaired in experimental type 2 diabetic rat models. Turkish Journal of Medical Sciences, Cilt: 44 - Sayı: 3, 448–453. https://ajindex.com/articles/257957

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Kaynakça (11)

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