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Dergiler / Hacettepe Journal of Biology and Chemistry / 2018 / Cilt: 46 - Sayı: 2

Arylidene Carbazole Carbohydrazides: Synthesis and Characterization

Cevher Gündoğdu HIZLIATEŞ
Sayfa
169–175
Yayın Tarihi
2018-06-03
DOI
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Yapay Zeka Hızlı Bakış & Çıkarımlar

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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

After determination of the melting points of all synthesized derivatives, their structures were identified by FT-IR and 1 H-NMR spectroscopic methods.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Because of the wide range of pharmacological activities and their distinctive structural features hydrazones and carbazole alkaloids have attracted considerable attention in medicinal chemistry.
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Temel Bulgular & Veri:In this study, new carbazole acyl hydrozones (3a-k) which may have high biological activity potential, were synthesized with condensation reaction between carbazole hydrazide and benzaldehyde derivatives.
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Sonuç & Katkı:After determination of the melting points of all synthesized derivatives, their structures were identified by FT-IR and 1 H-NMR spectroscopic methods.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Carbazole · carbohydrazide · hydrazide-hydrazone

Abstract

Because of the wide range of pharmacological activities and their distinctive structural features hydrazones and carbazole alkaloids have attracted considerable attention in medicinal chemistry. In this study, new carbazole acyl hydrozones (3a-k) which may have high biological activity potential, were synthesized with condensation reaction between carbazole hydrazide and benzaldehyde derivatives. After determination of the melting points of all synthesized derivatives, their structures were identified by FT-IR and 1 H-NMR spectroscopic methods.

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Bu Makaleye Atıf Yap

HIZLIATEŞ, C. G. (2018). Arylidene Carbazole Carbohydrazides: Synthesis and Characterization. Hacettepe Journal of Biology and Chemistry, Cilt: 46 - Sayı: 2, 169–175. https://ajindex.com/articles/255645

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Kaynakça (11)

  1. J.R. Dimmock, S.C. Vashishtha, J.P. Stables, Anticonvulsant properties of various acetylhydrazones, oxamoylhydrazones and semicarbazones derived from aromatic and unsaturated carbonyl compounds, Eur. J. Med. Chem., 35 (2000) 241-248.
  2. J. Ragavendran, D. Sriram, S. Patel, I. Reddy, N. Bharathwajan, J. Stables, Design and synthesis of anticonvulsants from a combined phthalimide-GABAanilide and hydrazone pharmacophore, Eur. J. Med. Chem., 42 (2007) 146-151.
  3. N. Ergenç, N.S. Günay, Synthesis and antidepressant evaluation of new 3-phenyl-5-sulfonamid indole derivatives, Eur. J. Med. Chem., 33 (1998) 143-148.
  4. A.R. Todeschini, A.L. Miranda, C.M. Silva, S.C. Parrini, E.J. Barreiro, Synthesis and evaluation of analgesic, antiinflammatory and antiplatelet properties of new 2- pyridylarylhydrazone derivatives, Eur. J. Med. Chem., 33 (1998) 189-199.
  5. A.G.M. Fraga, C.R. Rodrigues, A.L.P. Miranda, E.J. Barreiro, C.A.M. Fraga, Synthesis and pharmacological evaluation of novel heterocyclic acylhydrazone derivatives, designed as PAF antagonists, Eur. J. Pharm. Sci., 11 (2000) 285-290.
  6. Walcourt, M. Loyevsky, D.B. Lovejoy, V.R. Gordeuk, D.R. Richardson, Novel aroylhydrazone and thiosemicarbazone iron chelators with anti-malarial activity against chloroquine-resistant and -sensitive parasites, Int. J. Biochem. Cell Biol., 36 (2004) 401- 407. P. Vicini, F. Zani, P. Cozzini, I. Doytchinova, Hydrazones of 1,2-benzisothiazole hydrazides: synthesis, antimicrobial activity and QSAR investigations, Eur. J. Med. Chem., 37 (2002) 553-564.
  7. J. Jayabharathi, A. Thangamani, M. Padmavathy, B. Krishnakumar, Synthesis and microbial evaluation of novel N(1)-Arilidene-N(2)-t(3)-methyl-r(2), c(6)-diarylpiperidin-4-one azine derivatives, Med. Chem. Res., 15 (2007) 431-442.
  8. MT. Cocco, C. Congiu, V. Onnis, MC. Pusceddu, ML. Schivo, A. Logu, Synthesis and antimycobacterial activity of some isonicotinoylhydrazones, Eur. J. Med. Chem., 34 (1999) 1071-1076.
  9. S.G. Küçükgüzel, S. Rollas, I. Küçükgüzel, M. Kiraz, Synthesis and antimycobacterial activity of some coupling products from 4-aminobenzoic acid hydrazones, Eur. J. Med. Chem., 34 (1999) 1093-1100.
  10. B.K. Kaymakçıoğlu, S. Rollas, Synthesis, characterization and evaluation of antituberculosis activity of some hydrazones, Farmaco, 57 (2002) 595-599.
  11. D.G. Rando, D.N. Sato, L. Siqueira, A. Malvezzi, C.Q. F. Leite, A.T. Amaral, Potential tuberculostatic agents. Topliss application on benzoic acid [(5-nitro-thiophen2-yl)-methylene]-hydrazide series, Bioorg. M