A high yielding and fast method for the synthesis of 1,4-Dihydropyrano[2,3-c] pyrazole via one-pot, three component reaction of an aromatic aldehyde, malonitrile and 3-methyl-1-phenyl-2-pyrazolin-5-one using p-toluene sulfonic acid as a catalyst is described Keywords: p-toluene sulfonic acid, 1,4-dihydropyrano[2,3-c]pyrazole, one-pot.
📌 3 Maddede Bu Makale
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Amaç & Hipotez:A high yielding and fast method for the synthesis of 1,4-Dihydropyrano[2,3-c] pyrazole via one-pot, three component reaction of an aromatic aldehyde, malonitrile and 3-methyl-1-phenyl-2-pyrazolin-5-one using p-toluene sulfonic acid as a catalyst is described Keywords: p-toluene sulfonic acid, 1,4-dihydropyrano[2,3-c]pyrazole, one-pot.
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Temel Bulgular & Veri:A high yielding and fast method for the synthesis of 1,4-Dihydropyrano[2,3-c] pyrazole via one-pot, three component reaction of an aromatic aldehyde, malonitrile and 3-methyl-1-phenyl-2-pyrazolin-5-one using p-toluene sulfonic acid as a catalyst is described Keywords: p-toluene sulfonic acid, 1,4-dihydropyrano[2,3-c]pyrazole, one-pot.
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Sonuç & Katkı:A high yielding and fast method for the synthesis of 1,4-Dihydropyrano[2,3-c] pyrazole via one-pot, three component reaction of an aromatic aldehyde, malonitrile and 3-methyl-1-phenyl-2-pyrazolin-5-one using p-toluene sulfonic acid as a catalyst is described Keywords: p-toluene sulfonic acid, 1,4-dihydropyrano[2,3-c]pyrazole, one-pot.
A high yielding and fast method for the synthesis of 1,4-Dihydropyrano[2,3-c] pyrazole via one-pot, three component reaction of an aromatic aldehyde, malonitrile and 3-methyl-1-phenyl-2-pyrazolin-5-one using p-toluene sulfonic acid as a catalyst is described Keywords: p-toluene sulfonic acid, 1,4-dihydropyrano[2,3-c]pyrazole, one-pot.
HERAVİ, M., JAVANMARDİ, N., OSKOOİE, H., BAGHERNEJAD, B. (2011). A Facile One Pot Synthesis Of Pyrano[2,3-C]Pyrazole Derivatives Using P-Toluene Sulfonic Acid In Aqueous Media. Gazi University Journal of Science, Cilt: 24 - Sayı: 2, 227–231. https://ajindex.com/articles/255107
Witte, E.C., Neubert, P., Roesoh, A., ”2H-1- benzopyran-2-on derivatives, process for their preparation and medicines containing these compounds“, Ger. Offen. DE., 3427985 (1986), Chem. Abstr. 104, 224915f (1986).
Armetso, D., Horspool, W.M., Martin, N., Ramos, A., Seaone, C.,” Synthesis of cyclobutenes by the novel photochemical ring contraction of 4- substituted pyrans“, J. Org. Chem., 54: 3069–3072 (1989).
Martin, L.N., Quinteiro, M., Seoane, C., Soto, J.L.,” Synthesis of 4H-pyrans“, Liebigs. Ann. Chem., 1: 101-104 (1991).
Maco, J.L., Martin, N., Grau, A.M., Seoane, C., Albert, A., Cano, F. H., ”Development of methods for the synthesis of chiral, highly functionalized 2- amino-4-aryl-4H-pyrans“, Tetrahedron., 50: 3509- 3528 (1994).
Li, C.J., Chan, T.H.,”Organic Reactions in Aqueous Media“, Wiley: New York (1997).
Li, C.J., ”Organic Reactions in Aqueous Media with a Focus on Carbon−Carbon Bond Formations: A Decade Update“, Chem. Rev., 105: 3095–3166 (2005).
Breslow, R., ”Hydrophobic effects on simple organic reactions in water“, Acc. Chem. Res., 24: 159–164 (1991).
Breslow, R., ”Determining the Geometries of Transition States by Use of Antihydrophobic Additives in Water“, Acc. Chem. Res., 37:471–478 (2004).
Narasimhulu, M., Mahesh, K.C., Reddy, T.S., Rajesh, K., Venkateswarlu, Y., ”Lanthanum(III) nitrate hexahydrate or p-toluenesulfonic acid catalyzed quinazolinones under solvent-free conditions“, Tetrahedron Lett., 47: 4381-4383 (2006). 4(3H) GU J Sci., 24(2):227-231 (2011)/ Majid M. HERAVI1, Najme JAVANMARDI1, Hossein A.OSKOOIE1, Bita BAGHERNEJAD1 Anuradha, V.; Srinivas, P. V.; Aparna, P.; Rao, J. M.,” p-Toluenesulfonic acid catalyzed regiospecific nitration Tetrahedron Lett., 47: 4933-4935 (2006). metal nitrates“, Li, T.; Souma, Y.; Xu, Q., ”Carbonylation of formaldehyde catalyzed by p-toluenesulfonic acid“, Catal. Today., 111: 288-291 (2006).
Bamoharram, F.F., Heravi, M.,”Catalytic Method for Synthesis of Aspirin by a Green, Efficient and Recyclable Solid Acid Catalyst Temperature“, J. Chin.Chem. Soc., 54: 1017-1020 (2007).
M.M., Roshani, (Preyssler’s Anion) at Room [15] Heravi, M.M., Bakhtiari, H.A.,”Communication: KHSO4 Supported onto Bentonite, A Versatile Reagent for Aromatization of Hantzsch 1,4-Dihydropyridines“, J. Chin. Chem. So