Dergiler / Gazi University Journal of Science / 2014 / Cilt: 27 - Sayı: 3

Lead Nitrate Induced Oxidative Stress in Brain Tissues of Rats: Protective Effect of Sodium Selenite

Sayfa
883–889
Yayın Tarihi
2014-04-28
DOI
—
🏛️Bu makalenin bibliyografik verileri ve tam metin bağlantısı DergiPark üzerinden sağlanmıştır.
DergiPark Kaydı ↗
✨

Yapay Zeka Hızlı Bakış & Çıkarımlar

AI Insight
⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

At the end of the study, we showed that lead nitrate causes oxidative stress in diabetic and non-diabetic rat brain and the sodium selenite can ameliorate this toxicity, but not protect completely.

📌 3 Maddede Bu Makale

🎯
Amaç & Hipotez:Lead used in many industrial applications and it has been recognized as a toxic metal.
📊
Temel Bulgular & Veri:The aim of this study is to investigate the effects of lead nitrate on brain tissues of diabetic and non-diabetic rats and the protective role of sodium selenite.
💡
Sonuç & Katkı:At the end of the study, we showed that lead nitrate causes oxidative stress in diabetic and non-diabetic rat brain and the sodium selenite can ameliorate this toxicity, but not protect completely.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Lead Nitrate · Sodium selenite · Antioxidant Enzymes

Abstract

Lead used in many industrial applications and it has been recognized as a toxic metal. The aim of this study is to investigate the effects of lead nitrate on brain tissues of diabetic and non-diabetic rats and the protective role of sodium selenite. Four weeks later, changes in antioxidant enzyme activities and MDA levels determined in the brain tissues. At the end of the study, we showed that lead nitrate causes oxidative stress in diabetic and non-diabetic rat brain and the sodium selenite can ameliorate this toxicity, but not protect completely.

🔖

Bu Makaleye Atıf Yap

KALENDER, S., APAYDIN, F., DEMİR, F., BAŞ, H. (2014). Lead Nitrate Induced Oxidative Stress in Brain Tissues of Rats: Protective Effect of Sodium Selenite. Gazi University Journal of Science, Cilt: 27 - Sayı: 3, 883–889. https://ajindex.com/articles/254755

📄 Tam Metin PDF Okuyucu

📄

PDF görüntüleyici hazırlanıyor...

Kaynakça (9)

  1. Al-Attar, A.M., “Vitamin E attenuates liver injury induced by exposure to lead, mercury, cadmium and copper in albino mice”, Saudi J. Biol. Sci. 18: 395-401 (2011).
  2. Pan, T., Wang, P., Al-Suwayeh, S.A., Chen, C., Fang, Y., “Skin toxicology of lead species evaluated by their comparison of organic and inorganic lead”, Toxicology Lett. 197: 19–28 (2010). proteomic profiles: A Narayana, K., Al-Bader, M., “Ultrastructural and DNA damaging effects of lead nitrate in the liver”, Exp. Toxicol. Pathol. 63: 43-51 (2011).
  3. Suematsu, N., Hosoda, M., Fujimori, K., “Protective effects of quercetin against hydrogen peroxide-induced apoptosis in human neuronal SH-SY5Y cells”, Neurosci. Lett. 504: 223-227 (2011).
  4. Aydın, M., Çelik, S., “Effects of lycopene on plasma glucose, insulin levels, oxidative stress, and body weights of streptozotocin-induced diabetic rats”, Turk J. Med. Sci. 42: 1406-1413 (2012).
  5. Kalender, S., Uzun, F.G., Demir, F., Uzunhisarcıklı, M., testicular toxicity in rats and the protective role of sodium selenite and vitamin E”, Food Chem. Toxicol. 55: 456-462 (2013). chloride-induced [7] Bhutada, P., Mundhada, Y., Bansod, K., Bhutada, C., Tawari, S., Dixit, P., Mundhada, D., “Ameliorative effect of quercetin on memory dysfunction in streptozotocin-induced Learn. Mem. 94: 293-302 (2010). rats”, Neurobiol. and antioxidant defense under lead [12] Schmatz, R., Mazzanti, C.M., Spanevello, R., Stefanello, N., Gutierres, J., Corrêa, M., Melgarejo da Rosa, M., Rubin, M.A., Schetinger, M.R.C., Morsch, V.M., “Resveratrol prevents memory deficits and the increase streptozotocin-induced Pharmacol. 610: 42-48 (2009). activity in J. diabetic rats”, Eur. Ohkawa, H., Ohishi, N., Yagi, K., “Assay for lipid peroxides in animal tissues by thiobarbituric acid rection”, Anal. Biochem, 95: 351-358 (1979).
  6. Marklund, S., Marklund, G., “Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase”, Eur. J. Biochem. 47: 469-474 (1974).
  7. Aebi, H., “Catalase in vitro”, Method Enzymol. 105: 121-126 (1984).
  8. Paglia, D.E., Valentine, W.N., “Studies on the quantative glutathione peroxidase”, J. Labor. Med. 70: 158-165 (1987). characterization of Habig, W.H., Pabst, M.J., Jakoby, W.B., “Glutathione-S-transferases: the first enzymatic step in mercapturic acid formation”, J. Biol. Chem. 249: 7130- 7139 (1974).
  9. Pande, M., Flora, S.J.S., “Lead induced oxidative damage and its response to combined administration of α-lipoic acid and