Dergiler / Düşünen Adam - Psikiyatri ve Nörolojik Bilimler Dergisi / 2020 / Cilt: 33 - Sayı: 4

Does late and early onset depression differ in terms of inflammation?

Sayfa
334–339
DOI
—
🏛️Bu makalenin bibliyografik verileri ve tam metin bağlantısı DergiPark üzerinden sağlanmıştır.
DergiPark Kaydı ↗
✨

Yapay Zeka Hızlı Bakış & Çıkarımlar

AI Insight
⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Conclusion: NLR and PLR may be regarded as markers reflecting inflammation in geriatric depression patients rather than as markers that can differentiate geriatric depression patients in terms of disease onset time.

📌 3 Maddede Bu Makale

🎯
Amaç & Hipotez:Objective: To compare neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), and monocyte-lymphocyte ratio (MLR) values as inflammation markers in patients with early- and late-onset geriatric depression.
📊
Temel Bulgular & Veri:Method: Patients aged 60 and over who were hospitalized due to depressive disorder between 01.01.2012 and 01.01.2020 were included in this retrospective record review study.
💡
Sonuç & Katkı:Conclusion: NLR and PLR may be regarded as markers reflecting inflammation in geriatric depression patients rather than as markers that can differentiate geriatric depression patients in terms of disease onset time.
🔬Tür:Literatür & Derleme Çalışması
📍Kapsam:2012 Verileri
⚙️Değişkenler:Alan Parametreleri

Özet

Objective: To compare neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), and monocyte-lymphocyte ratio (MLR) values as inflammation markers in patients with early- and late-onset geriatric depression. Method: Patients aged 60 and over who were hospitalized due to depressive disorder between 01.01.2012 and 01.01.2020 were included in this retrospective record review study. Only patients with unipolar depression were included. Results: No difference was found in terms of NLR, PLR or MLR was found between early- and late-onset depression. However, NLR and PLR values were higher in the early- and late-onset depression groups than in the control group. Lymphocyte and monocyte counts were higher in the control group compared to the early- and late-onset depression groups. Conclusion: NLR and PLR may be regarded as markers reflecting inflammation in geriatric depression patients rather than as markers that can differentiate geriatric depression patients in terms of disease onset time.

🔖

Bu Makaleye Atıf Yap

özdin, S., ÖZDİN, Ş. B. (2020). Does late and early onset depression differ in terms of inflammation?. Düşünen Adam - Psikiyatri ve Nörolojik Bilimler Dergisi, Cilt: 33 - Sayı: 4, 334–339. https://ajindex.com/articles/218460

📄 Tam Metin PDF Okuyucu

📄

PDF görüntüleyici hazırlanıyor...

Kaynakça (13)

  1. Turkish Statistical Institute (TUIK), Population and Demography. https://data.tuik.gov.tr/kategori/getkategori?p=nufus-vedemografi-109&dil=1. Accessed February 01,2020
  2. Naveen KHS, Goel AD, Dwivedi S, Hassan MA. Adding life to years: Role of gender and social and family engagement in geriatric depression in rural areas of Northern India. J Family Med Prim Care 2020; 9:721-728
  3. Aziz R, Steffens DC. What are the causes of late-life depression? Psychiatr Clin North Am 2013; 36:497-516
  4. Dols A, Bouckaert F, Sienaert P, Rhebergen D, Vansteelandt K, Ten Kate M, et al. Early- and late-onset depression in late life: a prospective study on clinical and structural brain characteristics and response to electroconvulsive therapy. Am J Geriatr Psychiatry 2017; 25:178-189
  5. Alexopoulos GS, Young RC, Meyers BS, Abrams RC, Shamoian CA. Late-onset depression. Psychiatr Clin North Am 1988; 11:101-115
  6. Paranthaman R, Burns AS, Cruickshank JK, Jackson A, Scott ML, Baldwin RC. Age at onset and vascular pathology in late-life depression. Am J Geriatr Psychiatry 2012; 20:524-532
  7. Franceschi C, Campisi J. Chronic inflammation (inflammaging) and its potential contribution to age-associated diseases. J Gerontol A Biol Sci Med Sci 2014; 69(Suppl 1):S4-9
  8. Alexopoulos GS, Morimoto SS. The inflammation hypothesis in geriatric depression. Int J Geriatr Psychiatry 2011; 26:1109-1118
  9. Teunissen CE, Durieux-Lu S, Blankenstein MA, Oude Voshaar RC, Comijs HC. The inflammatory marker GDF-15 is not independently associated with late-life depression. J Psychosom Res 2016; 83:46-49
  10. Alexopoulos GS. Mechanisms and treatment of late-life depression. Transl Psychiatry 2019; 9:188
  11. Sonsin-Diaz N, Gottesman RF, Fracica E, Walston J, Windham BG, Knopman DS, et al. Chronic systemic ınflammation ıs associated with symptoms of late-life depression: the arıc study. Am J Geriatr Psychiatry 2020; 28:87-98
  12. Mishra D, Sardesai U, Razdan R. C-reactive protein level in lateonset depression: a case-control study. Indian J Psychiatry 2018; 60:467-471. 13. de la Torre-Luque A, Ayuso-Mateos JL, Sanchez-Carro Y, de la Fuente J, Lopez-Garcia P. Inflammatory and metabolic disturbances are associated with more severe trajectories of latelife depression. Psychoneuroendocrinology 2019; 110:104443
  13. Charlton RA, Lamar M, Zhang A, Ren X, Ajilore O, Pandey GN, et al. Associations between pro-inflammatory cytokines, learning, and memory in late-life depression and healthy aging. Int J