Dergiler / Turkish Journal of Chemistry / 2008 / Cilt: 32 - Sayı: 1

Preparation of 1,5-Diketones by Addition of Cyclohexanone to Chalcones under Solvent-free Phase Transfer Catalyst Condition

Sayfa
55–61
Yayın Tarihi
2008-01-01
DOI
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

The mechanistic pathway of the reaction can be explained by the Michael-type addition of cyclohexanone to chalcone derivatives (3a-h).

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Amaç & Hipotez:Eight different chalcone-1,5-diketone derivatives (5a-h) were prepared by the reaction of chalcone derivatives (3a-h) with cyclohexanone under the solvent-free phase transfer catalyst condition with modarate to high yields.
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Temel Bulgular & Veri:Eight different chalcone-1,5-diketone derivatives (5a-h) were prepared by the reaction of chalcone derivatives (3a-h) with cyclohexanone under the solvent-free phase transfer catalyst condition with modarate to high yields.
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Sonuç & Katkı:The mechanistic pathway of the reaction can be explained by the Michael-type addition of cyclohexanone to chalcone derivatives (3a-h).
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Chalcones · 5-Diketones · Solvent-free

Özet

Eight different chalcone-1,5-diketone derivatives (5a-h) were prepared by the reaction of chalcone derivatives (3a-h) with cyclohexanone under the solvent-free phase transfer catalyst condition with modarate to high yields. The mechanistic pathway of the reaction can be explained by the Michael-type addition of cyclohexanone to chalcone derivatives (3a-h).

Abstract

Eight different chalcone-1,5-diketone derivatives (5a-h) were prepared by the reaction of chalcone derivatives (3a-h) with cyclohexanone under the solvent-free phase transfer catalyst condition with modarate to high yields. The mechanistic pathway of the reaction can be explained by the Michael-type addition of cyclohexanone to chalcone derivatives (3a-h).

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Bu Makaleye Atıf Yap

CEYLAN, M., GEZEGEN, H. (2008). Preparation of 1,5-Diketones by Addition of Cyclohexanone to Chalcones under Solvent-free Phase Transfer Catalyst Condition. Turkish Journal of Chemistry, Cilt: 32 - Sayı: 1, 55–61. https://ajindex.com/articles/217976

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Kaynakça (29)

  1. M. Satyanarayana, P. Tiwari, B. K. Tripathi, A. K. Sriwastava, R. Pratap, Bioorg. Med. Chem., 12, 883, (2004).
  2. S. Mukherjee, N. Kumar, A. K. Parasad, H. G. Raj, M. E. Bracke, C. E. Olsen, S. C. Jain, V. S. Parmar, Bioorg. Med. Chem., 9, 337 (2001).
  3. H. K. Hsieh, L. T. Tsao, J. P. Wang, C. N. Lin, J. Pharm. Pharmacol., 52, 163 (2000).
  4. V. J. Ram, A. S. Saxena, S. Srivastava, S. Chandra, Bioorg. Med. Chem. Lett., 10, 2159 (2000).
  5. L. Zhai, M. Chen, J. Blam, T. G. Theander, S. B. Chiristensen, A. Kharazmi, J. Antimicrob. Chemother., (1999).
  6. R. J. Anto, K. Sukumuran, G. Kuttan, M. N. A. Rao, V. Subbaraju, R. Kuttan, Cancer Lett., 97, 33 (1995).
  7. S. K. Kumar, E. Hager, P. Catherine, H. Gurulingappa, N. E. Davidson, S. R. Khan, J. Med. Chem., 46, (2003).
  8. Z. S. Arigan, H. Suschitiky, J. Chem. Soc., 2242 (1961).
  9. F. Krohnke, Synthesis, 1, (1976).
  10. E. C. Constable, A. M. W. Cargill, J. Chem. Soc. Dalton Trans., 2947 (1992).
  11. I. R. Butler, S. J. Mcdonald, Polyhedron, 14, 529 (1995).
  12. B. S. Goud, K. Panneerselvam, D. E. Zacharis, G. R. Desiraju, J. Chem. Soc.Perkin Trans., 2, 325 (1995).
  13. X. L. Li, Y. M. Wang, T. Matsuura, J. B. Meng, J. Heterocyc. Chem., 36, 697 (1999).
  14. W. Y. Liu, Q. H. Xu, Y. M. Liang, B. H. Chen, W. M. Liu, Y. X. Ma, J. Organomet. Chem., 637-639, 719 (2001).
  15. A. Hoz, E. D. Barra, F. Langa, S. Merino, A. Rodriguez, P. S. Verdu, Tetrahedron, 53, 34, 11693 (1997).
  16. A. G. Raso, J. G. Raso, B. Campaner, R. Mestres, J. V. Sinisterra, Comunications, 1037 (1982).
  17. S. Wattanasin, W. S. Murphy, Synthesis, 647 (1980).
  18. D. G. Powers, D. S. Casebier, D. Fokas, W. J. Ryan, J. R. Troth, D. L. Coffen, Tetrahedron, 54, 4085 (1998).
  19. Y. Sasson, M. Cohen, J. Blum, Communucations, 359, (1973).
  20. D. G. Batt, R. Goodman, D. G. Jones, J. S. Kerr, L. R. Mantegna, C. McAllister, R. C. Newton, S. Nurnberg, P. K. Welch, M. B. Covington, J. Med. Chem., 36, 1434 (1993).
  21. O. V. Singh, C. P. Garg, R. P. Kapoor, Synthesis, 1025 (1990).
  22. E. J. Corey, F. Y. Zhang, Org. Lett., 1, 1287 (1999).
  23. F. Y. Zhang, E. J. Corey, Org. Lett., 2, 1097 (2000).
  24. N. H. Num, Y. Kim, Y. J. You, D. H. Hong, H. M. Kim, B. Z. Ahn, Eur. J. Med. Chem., 38, 179 (2003).
  25. Y. Hu, X. Liang, J. Wang, Z. Zheng, X. Hu, J. Org. Chem., 68, 4542 (2003).
  26. S. Harada, N. Kumagai, T. Kinoshita, S. Matsunaga, M. Shibasaki, J. Am. Chem. Soc., 125, 2582 (2003).
  27. A. Puschl, H. C. Rudbeck, A. Faldt, A. Confante, J. Kehler, Synthesis, 291 (2005).
  28. J. Wang, H. Li, L. Zu, W. Wang, Adv. Synth. Catal., 425 (2006).
  29. T. G. Nikolaeva, N. V. Petrova, A. P