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Dergiler / Turkish Journal of Chemistry / 2020 / Cilt: 44 - Sayı: 5

Synthesis, characterization and evaluation of antidengue activity of enantiomeric Schiff bases derived from S-substituted dithiocarbazate

Maqsood MARYAM
Sang Loon TAN
Karen Ann CROUSE
Mohamed Ibrahim MOHAMED TAHİR
Hui-yee CHEE
Sayfa
1395–1409
Yayın Tarihi
2020-10-26
DOI
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

The enantiomers of the compounds behaved almost similarly during the antiviral evaluation.

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Amaç & Hipotez:A series of Schiff bases have been successfully synthesized through the acid-catalyzed condensation of S-substituted dithiocarbazates and three enantiomerically pure monoterpenes, (1R)-(+)-camphor, (1S)-(-)-camphor, (1R)-(-)-camphorquinone, (1S)-(+)-camphorquinone, (R)-(-)-carvone and (S)-(+)-carvone.
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Temel Bulgular & Veri:The antidengue potential of these compounds was evaluated based on DENV 2 caused cytopathic effect (CPE) reduction-based in vitro evaluation.
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Sonuç & Katkı:The enantiomers of the compounds behaved almost similarly during the antiviral evaluation.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Dithiocarbazate Schiff base · enantiomers · camphor

Abstract

A series of Schiff bases have been successfully synthesized through the acid-catalyzed condensation of S-substituted dithiocarbazates and three enantiomerically pure monoterpenes, (1R)-(+)-camphor, (1S)-(-)-camphor, (1R)-(-)-camphorquinone, (1S)-(+)-camphorquinone, (R)-(-)-carvone and (S)-(+)-carvone. Spectroscopic results revealed that the Schiff bases containing camphor or carvone likely adopted an E-configuration along the characteristic imine bond while those containing camphorquinone assumed a Z-configuration. The antidengue potential of these compounds was evaluated based on DENV 2 caused cytopathic effect (CPE) reduction-based in vitro evaluation. The compounds were validated through secondary foci forming unit reduction assay (FFURA). Compounds were also tested for their cytotoxicity against Vero cells. The compounds showed variable degrees of antiviral activity with the camphor compounds displaying the highest antidengue potential. The enantiomers of the compounds behaved almost similarly during the antiviral evaluation.

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Bu Makaleye Atıf Yap

MARYAM, M., TAN, S. L., CROUSE, K. A., TAHİR, M. I. M., CHEE, H. (2020). Synthesis, characterization and evaluation of antidengue activity of enantiomeric Schiff bases derived from S-substituted dithiocarbazate. Turkish Journal of Chemistry, Cilt: 44 - Sayı: 5, 1395–1409. https://ajindex.com/articles/212683

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