Dergiler / Kocaeli Tıp Dergisi / 2019 / Cilt: 8 - Sayı: 2

Role of MPV and Platelet/MPV Ratio in The Diagnosis of Cardiac Dilemma; Cardiac or Non-Cardiac Chest Pain, and Severity of Acute Coronary Syndrome

Kardiyak Göğüs Ağrısı ve Akut Koroner Sendrom Şiddeti Ayırıcı Tanısında MPV ve Platenet/MPV Oranının Rolü

Sayfa
182–190
DOI
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A statistically significant difference was detected between cardiac and non-cardiac patients with regard to platelet, MPV and plt/MPV values (p=0.005, p<0.001 p<0.001, respectively) DISCUSSION and CONCLUSION: Although MPV values and platelet/MPV ratio are not sufficient to use alone in routine daily practice, we consider that MPV and the platelets/MPV ratio are significant as dependent markers for the diagnosis of ACS when used together with the other described risk factors in the literature

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Amaç & Hipotez:ABSTRACT INTRODUCTION: We aimed to investigate effectiveness of mean platelets volume (MPV) and platelet/MPV ratio as an independent marker on mortality for prediction of critical vascular stenosis in the differential diagnosis of acute coronary syndrome and cardiac/non-cardiac chest pain in patients presenting to the emergency department.
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Temel Bulgular & Veri:METHODS: Retrospective observational study included patients of 45 years of age and above presented to the ED with chest pain.
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Sonuç & Katkı:A statistically significant difference was detected between cardiac and non-cardiac patients with regard to platelet, MPV and plt/MPV values (p=0.005, p<0.001 p<0.001, respectively) DISCUSSION and CONCLUSION: Although MPV values and platelet/MPV ratio are not sufficient to use alone in routine daily practice, we consider that MPV and the platelets/MPV ratio are significant as dependent markers for the diagnosis of ACS when used together with the other described risk factors in the literature
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri

Özet

ABSTRACT INTRODUCTION: We aimed to investigate effectiveness of mean platelets volume (MPV) and platelet/MPV ratio as an independent marker on mortality for prediction of critical vascular stenosis in the differential diagnosis of acute coronary syndrome and cardiac/non-cardiac chest pain in patients presenting to the emergency department. METHODS: Retrospective observational study included patients of 45 years of age and above presented to the ED with chest pain. Patients were divided into groups with cardiac/non-cardiac chest pain. MPV, platelets/MPV ratio, coronary anjıography results, inhospital and 1-month hospital mortality were recorded RESULTS: A total of 753 patients; Cardiac pathology was determined in 282 (37.46%). The mean age was determined as 60.1 years and 59% were male. A statistically significant difference was detected between cardiac and non-cardiac patients with regard to platelet, MPV and plt/MPV values (p=0.005, p<0.001 p<0.001, respectively) DISCUSSION and CONCLUSION: Although MPV values and platelet/MPV ratio are not sufficient to use alone in routine daily practice, we consider that MPV and the platelets/MPV ratio are significant as dependent markers for the diagnosis of ACS when used together with the other described risk factors in the literature

Abstract

ÖZ GİRİŞ ve AMAÇ: Acil servise başvuran hastalarda akut koroner sendrom ve kardiyak / kardiyak olmayan göğüs ağrısının ayırıcı tanısı ile kritik vaskuler stenozun öngörülmesinde mortalite üzerine bağımsız bir belirteç olarak mean platelet volum (MPV) ve trombosit / MPV oranının etkinliğini araştırmak. YÖNTEM ve GEREÇLER: Retrospektif gözlemsel çalışmaya göğüs ağrısı ile acil servise başvuran 45 yaş ve üstü hastalar dahil edildi. Hastalar kardiyak / kardiyak olmayan göğüs ağrısı olarak gruplara ayrıldı. MPV, trombosit/ MPV oranı, koroner anjiyografi sonuçları, hastane içi ve 1 aylık hastane mortalitesi kaydedildi. BULGULAR: Çalışmaya katılan 753 hastanın %37,46'sında kardiyak patoloji tespit edildi. Tüm hastaların yaş ortalaması 60,1 ve tüm hastaların % 59'u erkekti. Kardiyak ve kardiyak olmayan hastalar arasında trombosit, Mean platelet volum (MPV) ve trombosit / MPV değerleri açısından istatistiksel olarak anlamlı bir fark saptanmıştır (sırasıyla p = 0.005, p <0.001 p <0.001).MPV, trombosit / MPV değerlerinin majör kardiyak advers olay gelişimini gösteren ROC eğrisi; eğri altında kalan alan MPV için 0.677 ve trombosit / MPV için 0.366 olarak bulunmuştur. Major kardiyak olay görülen hasta grubunda STEMI olan hastalara göre, STEMI-AKS olmayan hastalarda ortalama MPV değeri istatistiksel olarak anlamlı derecede düşüktü (p = 0.003). Kritik stenoz saptanmayan hastalara göre MPV değeri istatistiksel olarak anlamlı derecede yüksek ve ortalama trombosit / MPV değeri istatistiksel olarak anlamlı derecede düşüktü (p≤0.001). TARTIŞMA ve SONUÇ: MPV ve trombosit düzeyinin tek başına kullanımlarının yetersiz olmasına rağmen, literatürde açıklanan diğer risk faktörleri ile birlikte kullanıldığında akut koroner sendrom tanısı için bağımsız belirteçler olarak kullanılabileceğini düşünmekteyiz.

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Bu Makaleye Atıf Yap

KARAKAYALI, O., YILMAZ, S., KARAKAYALI, A., BOZYEL, S. (2019). Role of MPV and Platelet/MPV Ratio in The Diagnosis of Cardiac Dilemma; Cardiac or Non-Cardiac Chest Pain, and Severity of Acute Coronary Syndrome. Kocaeli Tıp Dergisi, Cilt: 8 - Sayı: 2, 182–190. https://ajindex.com/articles/211153

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Kaynakça (6)

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