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AI InsightAmong the compounds, 4d showed antimicrobial activity against Candida albicans ATCC 60193 and Candida tropicalis ATCC 13803.
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Özet
Compounds 2 were synthesised via the reaction of 4-amino-5-thiophen-2-yl-methyl-2,4-dihydro-[1,2,4]-triazol-3-one (1) with aldehydes. Compounds 3 and 4 were obtained from compounds 2 with bromo acetophenone and ethyl bromoacetate, respectively. The synthesis of compounds 2, 3, and 4 and crystal structure of compound 2a are being reported. The molecular structures were identified by IR, 1H-NMR, 13C-NMR, MS, and elemental analyses. Compound 2a crystallises in the monoclinic P 21/n space group, with a = 6.565(5) Å, b = 18.278(5) Å, c = 13.8166(18) Å, b = 96.227(5)°, V = 1553.6(14) Å3, Z = 4. The newly compounds synthesised were screened for their antibacterial and antifungal properties. Among the compounds, 4d showed antimicrobial activity against Candida albicans ATCC 60193 and Candida tropicalis ATCC 13803.
Abstract
Compounds 2 were synthesised via the reaction of 4-amino-5-thiophen-2-yl-methyl-2,4-dihydro-[1,2,4]-triazol-3-one (1) with aldehydes. Compounds 3 and 4 were obtained from compounds 2 with bromo acetophenone and ethyl bromoacetate, respectively. The synthesis of compounds 2, 3, and 4 and crystal structure of compound 2a are being reported. The molecular structures were identified by IR, 1H-NMR, 13C-NMR, MS, and elemental analyses. Compound 2a crystallises in the monoclinic P 21/n space group, with a = 6.565(5) Å, b = 18.278(5) Å, c = 13.8166(18) Å, b = 96.227(5)°, V = 1553.6(14) Å3, Z = 4. The newly compounds synthesised were screened for their antibacterial and antifungal properties. Among the compounds, 4d showed antimicrobial activity against Candida albicans ATCC 60193 and Candida tropicalis ATCC 13803.