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Dergiler / Turkish Journal of Chemistry / 2008 / Cilt: 32 - Sayı: 6

Production of (S)-(-)-1-(1´-Napthyl) Ethanol by Rhodotorula glutinis Isolate Using Ram Horn Peptone

Esabi B. KURBANOĞLU
Kani ZİLBEYAZ
Namudar I. KURBANOĞLU
Sayfa
685–692
Yayın Tarihi
2008-06-01
DOI
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A simple process for the isolation of R. glutinis was also developed.

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Amaç & Hipotez:The bioreduction of 1-acetonaphthone 1 by locally isolated Rhodotorula glutinis strains using ram horn peptone (RHP) gave (S)-(-)-1-(1´-naphthyl) ethanol (2), an important pharmaceutical intermediate.
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Temel Bulgular & Veri:Optimum fermentation conditions for the production of 2 were 200 rpm, 32 °C, and pH 6.5.
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Sonuç & Katkı:A simple process for the isolation of R. glutinis was also developed.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Acetonapthone · bioreduction · microbial reduction

Özet

The bioreduction of 1-acetonaphthone 1 by locally isolated Rhodotorula glutinis strains using ram horn peptone (RHP) gave (S)-(-)-1-(1´-naphthyl) ethanol (2), an important pharmaceutical intermediate. R. glutinis strains were isolated from the water of fermented Salix leaves. Optimum fermentation conditions for the production of 2 were 200 rpm, 32 °C, and pH 6.5. The production of 2 with excellent enantiomeric excess (>99%), and good conversion (100%) and yield (78%) under optimum conditions was achieved up to preparative scale via a fermenter. Wide temperature, pH, time, and agitation ranges did not affect the enantiomeric excess (ee) of the bioreduction product. A simple process for the isolation of R. glutinis was also developed.

Abstract

The bioreduction of 1-acetonaphthone 1 by locally isolated Rhodotorula glutinis strains using ram horn peptone (RHP) gave (S)-(-)-1-(1´-naphthyl) ethanol (2), an important pharmaceutical intermediate. R. glutinis strains were isolated from the water of fermented Salix leaves. Optimum fermentation conditions for the production of 2 were 200 rpm, 32 °C, and pH 6.5. The production of 2 with excellent enantiomeric excess (>99%), and good conversion (100%) and yield (78%) under optimum conditions was achieved up to preparative scale via a fermenter. Wide temperature, pH, time, and agitation ranges did not affect the enantiomeric excess (ee) of the bioreduction product. A simple process for the isolation of R. glutinis was also developed.

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Bu Makaleye Atıf Yap

KURBANOĞLU, E. B., ZİLBEYAZ, K., KURBANOĞLU, N. I. (2008). Production of (S)-(-)-1-(1´-Napthyl) Ethanol by Rhodotorula glutinis Isolate Using Ram Horn Peptone. Turkish Journal of Chemistry, Cilt: 32 - Sayı: 6, 685–692. https://ajindex.com/articles/185056

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