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Dergiler / Turkish Journal of Chemistry / 2008 / Cilt: 32 - Sayı: 5

Novel Analogues of 2-Pyrazoline: Synthesis, Characterization, and Antimycobacterial Evaluation

Ahmet ÖZDEMİR
Gülhan TURAN-ZITOUNI
Zafer Asım KAPLANCIKLI
Sayfa
529–538
Yayın Tarihi
2008-05-01
DOI
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

The preliminary results showed that all of the tested compounds were inactive against the test organism.

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Amaç & Hipotez:Fourteen new 1-[(N,N-disubstitutedthiocarbamoylthio)acetyl]- 3-(2-thienyl)-5-aryl-2-pyrazoline derivatives were synthesized by reacting 1-(chloroacetyl)-3-(2-thienyl)-5-aryl-2-pyrazolines and appropriate sodium salts of N,N-disubstituted dithiocarbamoic acids in acetone.
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Temel Bulgular & Veri:The structures of the synthesized compounds were confirmed by UV, IR, 1H-NMR, and FAB+-MS spectral data.
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Sonuç & Katkı:The preliminary results showed that all of the tested compounds were inactive against the test organism.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:2-Pyrazolines · Sodium salts of N · N-disubstituted dithiocarbamoic acids

Özet

Fourteen new 1-[(N,N-disubstitutedthiocarbamoylthio)acetyl]- 3-(2-thienyl)-5-aryl-2-pyrazoline derivatives were synthesized by reacting 1-(chloroacetyl)-3-(2-thienyl)-5-aryl-2-pyrazolines and appropriate sodium salts of N,N-disubstituted dithiocarbamoic acids in acetone. The structures of the synthesized compounds were confirmed by UV, IR, 1H-NMR, and FAB+-MS spectral data. The compounds were evaluated for in vitro antimycobacterial activity against Mycobacterium tuberculosis H37Rv using the BACTEC 460 radiometric system and BACTEC 12B medium. The preliminary results showed that all of the tested compounds were inactive against the test organism.

Abstract

Fourteen new 1-[(N,N-disubstitutedthiocarbamoylthio)acetyl]- 3-(2-thienyl)-5-aryl-2-pyrazoline derivatives were synthesized by reacting 1-(chloroacetyl)-3-(2-thienyl)-5-aryl-2-pyrazolines and appropriate sodium salts of N,N-disubstituted dithiocarbamoic acids in acetone. The structures of the synthesized compounds were confirmed by UV, IR, 1H-NMR, and FAB+-MS spectral data. The compounds were evaluated for in vitro antimycobacterial activity against Mycobacterium tuberculosis H37Rv using the BACTEC 460 radiometric system and BACTEC 12B medium. The preliminary results showed that all of the tested compounds were inactive against the test organism.

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Bu Makaleye Atıf Yap

ÖZDEMİR, A., TURAN-ZITOUNI, G., KAPLANCIKLI, Z. A. (2008). Novel Analogues of 2-Pyrazoline: Synthesis, Characterization, and Antimycobacterial Evaluation. Turkish Journal of Chemistry, Cilt: 32 - Sayı: 5, 529–538. https://ajindex.com/articles/185003

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