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Dergiler / Turkish Journal of Chemistry / 2015 / Cilt: 39 - Sayı: 3

Two new coordination polymers containing dicyanidoargentate(I) and dicyanidoaurate(I): synthesis and characterization, and a detailed in vitro investigation of their anticancer activities on some cancer cell lines

ALİ AYDIN
AHMET KARADAĞ
ŞABAN TEKİN
NESRİN KORKMAZ
ASLIHAN ÖZDEMİR
Sayfa
532
Yayın Tarihi
2015-08-13
DOI
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

In conclusion, the results show that these novel compounds possess anticancer activities.

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Amaç & Hipotez:Two novel cyanido-bridged bimetallic polymeric complexes, [Ni(edbea)Ag$_{3}$(CN)$_{5}$]$_{n} $(C1) and [Ni(bishydeten) Au$_{2}$(CN)$_{4}$]$_{n}$ (C2), where edbea = [2,2$' $-(ethylenedioxy)bis(ethylamine)] and bishydeten = [($N$,$N' $-bis(2-hydroxyethyl) ethylenediamine)] are ligands, were synthesized and characterized by elemental, infrared, and thermal measurement techniques and investigated for their biological activity in cultured cancer cell lines.
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Temel Bulgular & Veri:The results show that both compounds and free anions, [Ag(CN)$_{2}$]$^{-}$ and [Au(CN)$_{2}$]$^{-}$, exhibited very high antiproliferative activity compared to the anticancer drug 5FU against the cancer cell lines tested.
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Sonuç & Katkı:In conclusion, the results show that these novel compounds possess anticancer activities.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Dicyanidoargentate(I) · dicyanidoaurate(I) · coordination polymers

Özet

Two novel cyanido-bridged bimetallic polymeric complexes, [Ni(edbea)Ag$_{3}$(CN)$_{5}$]$_{n} $(C1) and [Ni(bishydeten) Au$_{2}$(CN)$_{4}$]$_{n}$ (C2), where edbea = [2,2$' $-(ethylenedioxy)bis(ethylamine)] and bishydeten = [($N$,$N' $-bis(2-hydroxyethyl) ethylenediamine)] are ligands, were synthesized and characterized by elemental, infrared, and thermal measurement techniques and investigated for their biological activity in cultured cancer cell lines. The results show that both compounds and free anions, [Ag(CN)$_{2}$]$^{-}$ and [Au(CN)$_{2}$]$^{-}$, exhibited very high antiproliferative activity compared to the anticancer drug 5FU against the cancer cell lines tested. The antiproliferative and cytotoxic activities of C1 and C2 were significantly lower than those of free anions, indicating that the extreme cytotoxicity of free anions decreased to safe levels in C1 and C2. In conclusion, the results show that these novel compounds possess anticancer activities.

Abstract

Two novel cyanido-bridged bimetallic polymeric complexes, [Ni(edbea)Ag$_{3}$(CN)$_{5}$]$_{n} $(C1) and [Ni(bishydeten) Au$_{2}$(CN)$_{4}$]$_{n}$ (C2), where edbea = [2,2$' $-(ethylenedioxy)bis(ethylamine)] and bishydeten = [($N$,$N' $-bis(2-hydroxyethyl) ethylenediamine)] are ligands, were synthesized and characterized by elemental, infrared, and thermal measurement techniques and investigated for their biological activity in cultured cancer cell lines. The results show that both compounds and free anions, [Ag(CN)$_{2}$]$^{-}$ and [Au(CN)$_{2}$]$^{-}$, exhibited very high antiproliferative activity compared to the anticancer drug 5FU against the cancer cell lines tested. The antiproliferative and cytotoxic activities of C1 and C2 were significantly lower than those of free anions, indicating that the extreme cytotoxicity of free anions decreased to safe levels in C1 and C2. In conclusion, the results show that these novel compounds possess anticancer activities.

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Bu Makaleye Atıf Yap

AYDIN, A., KARADAĞ, A., TEKİN, Ş., KORKMAZ, N., ÖZDEMİR, A. (2015). Two new coordination polymers containing dicyanidoargentate(I) and dicyanidoaurate(I): synthesis and characterization, and a detailed in vitro investigation of their anticancer activities on some cancer cell lines. Turkish Journal of Chemistry, Cilt: 39 - Sayı: 3, 532. https://ajindex.com/articles/184987

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Kaynakça (11)

  1. ´ Avalos F´unez, A.; Isabel Haza, A.; Mateo, D.; Morales P. Toxicol. Mech. Methods. 2013, 23, 153–160.
  2. Berners-Price, S. J.; Johnson, R. K.; Giovenella, A. J.; Faucette, L. F.; Mirabelli, C. K.; Sadler, P. J. J. Inorg. Biochem. 1998, 33, 285–295.
  3. Boulikas, T.; Pantos, A.; Bellis, E.; Christofis, P. Cancer Therapy. 2007, 5, 537–583.
  4. Ott, I.; Gust, R. Arch. Pharm. Chem. Life Sci. 2007, 340, 117–126.
  5. Kelland, L. Nat. Rev. Cancer 2007, 7, 573. Kriel, F. H.; Coates, J. S. Afr. J. Chem. 2012, 65, 271–279.
  6. Zachariadis, P. C.; Hadjikakou, S. K.; Hadjiliadis, N.; Skoulika, S.; Michaelides, A.; Balzarini, J.; De Clercq, E. Eur. J. Inorg. Chem. 2004, 7, 1420–1426.
  7. El-Din, H. E. S.; Ahmed, S. S.; Ahmed, S. B. E. Eur. J. Med. Chem. 2011, 46, 5370–5378.
  8. Liu, J. J.; Galettis, P.; Farr, A.; Maharaj, L.; Samarasinha, H.; McGechan, A. C.; Baguley, B. C.; Bowen, R. J.; Berners-Price, S. J.; McKeage, M. J. J. Inorg. Biochem. 2008, 102, 303–310.
  9. Sun, R. W. Y.; Che, C. M. Coord. Chem. Rev. 2009, 253, 1682–1691.
  10. Chabner, A.; Lynch, T. J.; Longo, D. L.; Yılmaz, B. D. Harrison Onkoloji El Kitabı; Nobel Tıp Kitapevleri: ˙Istanbul, Turkey, 2009. 12.Dhar, S.; Lippard, S. J. Proc. Natl. Acad. Sci. 2009, 106, 22199–22204. 13.Wang, C. H.; Shih, W. C.; Chang, H. C.; Kuo, Y. Y.; Hung, W. C.; Ong, T. G.; Li, W. S. J. Med. Chem. 2011, 28, 5245–5249. 14.Thurston, D. E. Chemistry and Pharmacology of Anticancer Drugs; CRC Press, Taylor & Francis Group: Boca Raton, FL, USA, 2007. Karada˘g, A.; Keskin, G. A.; Yılmaz, V. T.; Yerli, Y.; S¸ahin, E. Polyhedron 2014, 78, 24–30. 16.Korkmaz, N. PhD, Department of Chemistry, University of Gaziosmanpa¸sa, Tokat, 2014. 17.S¸enocak, A.; Karada˘g, A.; Yerli, Y.; Anda¸c, ¨O.; S¸ahin, E. J. Inorg. Organomet. Polym. 2010, 20, 628–635.
  11. Hoboken, NJ, USA, 2009. 22.Yılmaz, V. T.; Karada˘g, A. Thermochim. Acta. 2000, 348, 121–127. 23.Yakupo˘glu, F.; Karada˘g, A.; S¸ekerci, M. J. Therm. Anal. Cal. 2006, 86, 727–731. Karada˘g, A. Z. Kristallogr. 2007, 222, 39–45. 25.Avenda´no, C.; Men´endez, J. C. Medicinal Chemistry of Anticancer Drugs; Elsevier BV: Amsterdam, the Nether- lands, 2008. 26.Gielen, M.; Tiekink, E. R. T. Metallotherapeutic Drugs and Metal-Based Diagnostic Agents—the Use of Metals in Medicine; John Wiley & Sons: West Sussex, UK, 2005. 27.Roche, V. F. In Foye’s Principles of Medicinal Chemistry; Williams, D. A.; Lemke, T., Eds. Lippincott Williams & Wilkins: Baltimore, MD, USA, 2002, pp. 1147–1192. 28.Batarseh, K. I. Curr. Med. Chem. 2013, 20, 2363–2373.