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Dergiler / Turkish Journal of Chemistry / 2014 / Cilt: 38 - Sayı: 5

Synthesis, anticandidal activity, and cytotoxicity of some thiazole derivatives with dithiocarbamate side chains

Leyla YURTTAŞ
Yusuf ÖZKAY
Fatih DEMİRCİ
Gamze GÖGER
Şafak Ulusoylar YILDIRIM
Usama ABU MOHSEN
Ömer ÖZTÜRK
Zafer Asım KAPLANCIKLI
Sayfa
815–824
Yayın Tarihi
2014-05-01
DOI
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Contrary to expectations, weak antifungal activity was observed with IC50 values ranging between 30 and 403 m g/mL.

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Amaç & Hipotez:Some thiazole derivatives bearing dithiocarbamic acid esters were synthesized in order to investigate their anticandidal activity and cytotoxicity.
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Temel Bulgular & Veri:The structures of the obtained final compounds (6a--j) were confirmed by spectral data (IR, 1H NMR, 13C NMR, and MS) and elemental analysis.
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Sonuç & Katkı:Contrary to expectations, weak antifungal activity was observed with IC50 values ranging between 30 and 403 m g/mL.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Thiazole · dithiocarbamate · anticandidal activity

Özet

Some thiazole derivatives bearing dithiocarbamic acid esters were synthesized in order to investigate their anticandidal activity and cytotoxicity. The structures of the obtained final compounds (6a--j) were confirmed by spectral data (IR, 1H NMR, 13C NMR, and MS) and elemental analysis. The anticandidal activity of the compounds was determined (6a--j) using the microbroth dilution method and their cytotoxicity was evaluated according to the MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay against normal cells. Contrary to expectations, weak antifungal activity was observed with IC50 values ranging between 30 and 403 m g/mL.

Abstract

Some thiazole derivatives bearing dithiocarbamic acid esters were synthesized in order to investigate their anticandidal activity and cytotoxicity. The structures of the obtained final compounds (6a--j) were confirmed by spectral data (IR, 1H NMR, 13C NMR, and MS) and elemental analysis. The anticandidal activity of the compounds was determined (6a--j) using the microbroth dilution method and their cytotoxicity was evaluated according to the MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay against normal cells. Contrary to expectations, weak antifungal activity was observed with IC50 values ranging between 30 and 403 m g/mL.

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Bu Makaleye Atıf Yap

YURTTAŞ, L., ÖZKAY, Y., DEMİRCİ, F., GÖGER, G., YILDIRIM, Ş. U., MOHSEN, U. A., ÖZTÜRK, Ö., KAPLANCIKLI, Z. A. (2014). Synthesis, anticandidal activity, and cytotoxicity of some thiazole derivatives with dithiocarbamate side chains. Turkish Journal of Chemistry, Cilt: 38 - Sayı: 5, 815–824. https://ajindex.com/articles/184794

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