KaydedilenlerDerginizi ekleyin

Dergiler / Turkish Journal of Chemistry / 2014 / Cilt: 38 - Sayı: 2

Aryl butenoic acid derivatives as a new class of histone deacetylase inhibitors: synthesis, in vitro evaluation, and molecular docking studies

Peruze AYHAN EŞİYOK
Özlem SEVEN
Gülüzar EYMUR
Gamze BORA TATAR
Didem DAYANGAÇ ERDEN
Kemal YELEKÇİ
Hayat YURTER
Ayhan Sıtkı DEMİR
Sayfa
338–344
Yayın Tarihi
2014-05-18
DOI
—
🏛️Bu makalenin bibliyografik verileri ve tam metin bağlantısı DergiPark üzerinden sağlanmıştır.
DergiPark Kaydı ↗
✨

Yapay Zeka Hızlı Bakış & Çıkarımlar

AI Insight
⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

These compounds have been shown to possess promising histone deacetylase inhibition activities via in vitro fluorometric assay and molecular docking studies.

📌 3 Maddede Bu Makale

🎯
Amaç & Hipotez:New aryl butenoic acid derivatives have been synthesized by combining hydroxy- or methoxy-substituted phenyl rings as the capping group, with a double bond in the short linker as well as metal binding groups, enoic ester, and salts bearing either methyl or morpholine.
📊
Temel Bulgular & Veri:New aryl butenoic acid derivatives have been synthesized by combining hydroxy- or methoxy-substituted phenyl rings as the capping group, with a double bond in the short linker as well as metal binding groups, enoic ester, and salts bearing either methyl or morpholine.
💡
Sonuç & Katkı:These compounds have been shown to possess promising histone deacetylase inhibition activities via in vitro fluorometric assay and molecular docking studies.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Histone deacetylase inhibition activity · aryl butenoic acid derivatives · molecular docking

Özet

New aryl butenoic acid derivatives have been synthesized by combining hydroxy- or methoxy-substituted phenyl rings as the capping group, with a double bond in the short linker as well as metal binding groups, enoic ester, and salts bearing either methyl or morpholine. These compounds have been shown to possess promising histone deacetylase inhibition activities via in vitro fluorometric assay and molecular docking studies.

Abstract

New aryl butenoic acid derivatives have been synthesized by combining hydroxy- or methoxy-substituted phenyl rings as the capping group, with a double bond in the short linker as well as metal binding groups, enoic ester, and salts bearing either methyl or morpholine. These compounds have been shown to possess promising histone deacetylase inhibition activities via in vitro fluorometric assay and molecular docking studies.

🔖

Bu Makaleye Atıf Yap

EŞİYOK, P. A., SEVEN, Ö., EYMUR, G., TATAR, G. B., ERDEN, D. D., YELEKÇİ, K., YURTER, H., DEMİR, A. S. (2014). Aryl butenoic acid derivatives as a new class of histone deacetylase inhibitors: synthesis, in vitro evaluation, and molecular docking studies. Turkish Journal of Chemistry, Cilt: 38 - Sayı: 2, 338–344. https://ajindex.com/articles/184679

📄 Tam Metin PDF Okuyucu

📄

PDF görüntüleyici hazırlanıyor...

Kaynakça (25)

  1. Ruijter, A. J. M.; Gennip, A. H.; Caron, H. N.; Kemp, S.; Kuilenburg, A. B. P. Biochem. J. 2003, 370, 737–749.
  2. Santini, V.; Gozzini, A.; Ferrari, G. Curr. Drug Metab. 2007, 8, 383–394.
  3. Bolden, J. E.; Peart, M. J.; Johnstone, R. W. Nat. Rev. Drug Disc. 2006, 5, 769–784.
  4. Liu, T.; Kuljaca, S.; Tee, A.; Marshall, G. M. Cancer Treat. Rev. 2006, 32, 157–165.
  5. Kazantsev, A. G.; Thompson, L. M. Curr. Drug Metab. 2007, 8, 383–394.
  6. Mercuri, E.; Bertini, E.; Messina, S.; Solari, A.; D’Amico, A.; Angelozzi, C.; Batini, R.; Berardinelli, A.; Boffi, P.; Bruno, C. et al. Neurology 2007, 68, 51–55.
  7. Brichta, L.; Holker, I.; Haug, K.; Klockgether, T.; Wirth, B. Ann. Neurol. 2006, 59, 970–975.
  8. Weihl, C. C.; Connolly, A. M.; Pestronk, A. Neurology 2006, 67, 500–501.
  9. Raine, C. S. J. Neuropathol. Exp. Neurol. 1994, 53, 328–337.
  10. McFarland, H. F.; Martin, R. Nature Immunol. 2007, 8, 913–919.
  11. Dheen, S. T.; Kaur, C.; Ling, E. A. Curr. Med. Chem. 2007, 14, 1189–1197.
  12. Drummond, D. C.; Noble, C. O.; Kirpotin, D. B.; Guo, Z.; Scott, G. K.; Benz, C. C. Ann. Rev. Pharmacol. Toxicol. 2005, 45, 495–528.
  13. Yoshida, M.; Kijima, M.; Akita, M.; Beppu, T. J. Biol. Chem. 1990, 265, 17174–17179.
  14. Grant, S.; Easley, C.; Kirkpatrick, P. Nat. Rev. Drug Discovery 2007, 6, 21–22.
  15. Bieliauskas, A. V.; Pflum, M. K. Chem. Soc. Rev. 2008, 37, 1402–1413.
  16. Dayangac-Erden, D.; Bora, G.; Ayhan, P.; Kocaefe, C.; Dalkara, S.; Yelekci, K.; Demir, A. S.; Erdem-Yurter, H. Chem. Biol. Drug Des. 2009, 73, 355–364.
  17. Zeiller, J. J.; Dumas, H.; Guyard-Dangremont, V.; Berard, I.; Contard, F.; Guerrirer, D.; Ferrand, G.; Bonhomme, Y. Patent WO/2005/014521, 2005.
  18. Katritzkyi, A. R.; Feng, D.; Qi, M. J. Org. Chem. 1998, 63, 1473–1477.
  19. Stecher, E. D.; Ryder, H. F. J. Am. Chem. Soc. 1952, 74, 4392–4395.
  20. Audrain, H.; Thorhauge, J.; Hazell, R. G.; Jİrgensen, K. A. J. Org. Chem. 2000, 65, 4487–4497.
  21. Wu, Y. C.; Liu, L.; Li, H. J.; Wang, D.; Chen, Y. J. J. Org. Chem. 2006, 71, 6592–6596.
  22. Morris, G. M.; Goodsell, D. S.; Halliday, R. S.; Huey, R.; Hart, W. E.; Belew, R. K.; Olson, A. J. J. Comput. Chem. 1998, 19, 1639–1662.
  23. Weiner, S. J.; Kollman, P. A.; Case, D. A.; Singh, U. C.; Ghio, C.; Alagona, G.; Profeta, S.; Weiner, P. J. Am. Chem. Soc. 1984, 106, 765–784.
  24. Weiner, S. J.; Kollman, P. A.; Nguyen, D. T.; Case, D. A. J. Comput. Chem. 1986, 7, 230–252.
  25. Huey, R.; Morris, G. M.; Olson, A. J.; Goodsell, D. S. J. Comput. Chem. 2007, 28, 1145–1152. Akdo˘ gan, E. D.; Erman, B.; Yelek¸ ci, K. Turk. J. Chem. 2011, 35, 523–542.