Asymmetric Henry reaction catalyzed by Cu(I)-based chiral amino alcohol complex

Amaç & Hipotez:The Cu(I)-based complex prepared from (S)-2-(furan-2-yl-methylamino)-2-phenylethanol (5c) and CuCl was used as catalyst in enantioselective Henry reactions of arylaldehydes and nitromethane, which gave 89% ee and 95% yield at ambient temperature.

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Temel Bulgular & Veri:The Cu(I)-based complex prepared from (S)-2-(furan-2-yl-methylamino)-2-phenylethanol (5c) and CuCl was used as catalyst in enantioselective Henry reactions of arylaldehydes and nitromethane, which gave 89% ee and 95% yield at ambient temperature.

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Sonuç & Katkı:The proposed catalytic cycle of an asymmetric Henry reaction was suggested.

🔬Tür:Araştırma Makalesi

📍Kapsam:Genişletilmiş Akademik Örneklem

⚙️Değişkenler:Chiral amino alcohol · copper(I) salt · asymmetric catalysis

Özet

The Cu(I)-based complex prepared from (S)-2-(furan-2-yl-methylamino)-2-phenylethanol (5c) and CuCl was used as catalyst in enantioselective Henry reactions of arylaldehydes and nitromethane, which gave 89% ee and 95% yield at ambient temperature. The proposed catalytic cycle of an asymmetric Henry reaction was suggested.

Abstract

The Cu(I)-based complex prepared from (S)-2-(furan-2-yl-methylamino)-2-phenylethanol (5c) and CuCl was used as catalyst in enantioselective Henry reactions of arylaldehydes and nitromethane, which gave 89% ee and 95% yield at ambient temperature. The proposed catalytic cycle of an asymmetric Henry reaction was suggested.

Anahtar kelimeler

Chiral amino alcohol copper(I) salt asymmetric catalysis Henry reaction

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Bu Makaleye Atıf Yap

SHEN, T., QIN, Q., NI, H., XIA, T., ZHOU, X., CUI, F., LI, J., RAN, D., SONG, Q. (2013). Asymmetric Henry reaction catalyzed by Cu(I)-based chiral amino alcohol complex. Turkish Journal of Chemistry, Cilt: 37 - Sayı: 6, 966–977. https://ajindex.com/articles/184647

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Kaynakça (5)

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