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Dergiler / Turkish Journal of Biology / 2010 / Cilt: 34 - Sayı: 1

In Vitro Genotoxic Effects of Benzoyl Peroxide in Human Peripheral Lymphocytes

Arzu YAVUZ
Mehmet TOPAKTAŞ
- *
Erman Salih İSTİFLİ
Sayfa
15–24
Yayın Tarihi
2010-01-01
DOI
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Statistically significant reductions in the proliferation index (PI) and mitotic index (MI) were only detected in cultures for the 48-h treatment period.

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Amaç & Hipotez:The aim of the present research was to investigate the genotoxic potency of benzoyl peroxide (BPO), a whitener of flour and cheese, using in vitro sister chromatid exchange (SCE), chromosome aberration (CA), and micronucleus (MN) tests in human peripheral lymphocytes.
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Temel Bulgular & Veri:Cells were exposed to 25, 50, 75, and 100 µg/mL concentrations of BPO for 24 and 48 h.
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Sonuç & Katkı:Statistically significant reductions in the proliferation index (PI) and mitotic index (MI) were only detected in cultures for the 48-h treatment period.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Key words: Benzoyl peroxide · human lymphocytes · sister chromatid exchange

Özet

The aim of the present research was to investigate the genotoxic potency of benzoyl peroxide (BPO), a whitener of flour and cheese, using in vitro sister chromatid exchange (SCE), chromosome aberration (CA), and micronucleus (MN) tests in human peripheral lymphocytes. Cells were exposed to 25, 50, 75, and 100 µg/mL concentrations of BPO for 24 and 48 h. BPO induced SCEs only at the highest concentration (100 µg/mL) for 48 h treatment. Furthermore, BPO induced CAs at 75 and 100 µg/mL concentrations for 24 h treatment, and at all concentrations for 48 h treatment. BPO induced CAs in a dose-dependent manner for 24 and 48 h treatment periods. Increased level of MN formation induced by BPO was only observed for the 48 h treatment period at the 2 highest concentrations (75 and 100 µg/mL). Statistically significant reductions in the proliferation index (PI) and mitotic index (MI) were only detected in cultures for the 48-h treatment period.

Abstract

The aim of the present research was to investigate the genotoxic potency of benzoyl peroxide (BPO), a whitener of flour and cheese, using in vitro sister chromatid exchange (SCE), chromosome aberration (CA), and micronucleus (MN) tests in human peripheral lymphocytes. Cells were exposed to 25, 50, 75, and 100 µg/mL concentrations of BPO for 24 and 48 h. BPO induced SCEs only at the highest concentration (100 µg/mL) for 48 h treatment. Furthermore, BPO induced CAs at 75 and 100 µg/mL concentrations for 24 h treatment, and at all concentrations for 48 h treatment. BPO induced CAs in a dose-dependent manner for 24 and 48 h treatment periods. Increased level of MN formation induced by BPO was only observed for the 48 h treatment period at the 2 highest concentrations (75 and 100 µg/mL). Statistically significant reductions in the proliferation index (PI) and mitotic index (MI) were only detected in cultures for the 48-h treatment period.

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Bu Makaleye Atıf Yap

YAVUZ, A., TOPAKTAŞ, M., *, -., İSTİFLİ, E. S. (2010). In Vitro Genotoxic Effects of Benzoyl Peroxide in Human Peripheral Lymphocytes. Turkish Journal of Biology, Cilt: 34 - Sayı: 1, 15–24. https://ajindex.com/articles/182449

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