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Journals / Turkish Journal of Biology / 2010 / Cilt: 34 - Sayı: 1

In Vitro Genotoxic Effects of Benzoyl Peroxide in Human Peripheral Lymphocytes

Arzu YAVUZ
Mehmet TOPAKTAŞ
- *
Erman Salih İSTİFLİ
Pages
15–24
Publication Date
2010-01-01
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Statistically significant reductions in the proliferation index (PI) and mitotic index (MI) were only detected in cultures for the 48-h treatment period.

📌 3 Key Takeaways

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Objective & Hypothesis:The aim of the present research was to investigate the genotoxic potency of benzoyl peroxide (BPO), a whitener of flour and cheese, using in vitro sister chromatid exchange (SCE), chromosome aberration (CA), and micronucleus (MN) tests in human peripheral lymphocytes.
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Key Findings & Data:Cells were exposed to 25, 50, 75, and 100 µg/mL concentrations of BPO for 24 and 48 h.
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Conclusion & Impact:Statistically significant reductions in the proliferation index (PI) and mitotic index (MI) were only detected in cultures for the 48-h treatment period.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Key words: Benzoyl peroxide · human lymphocytes · sister chromatid exchange

Abstract

The aim of the present research was to investigate the genotoxic potency of benzoyl peroxide (BPO), a whitener of flour and cheese, using in vitro sister chromatid exchange (SCE), chromosome aberration (CA), and micronucleus (MN) tests in human peripheral lymphocytes. Cells were exposed to 25, 50, 75, and 100 µg/mL concentrations of BPO for 24 and 48 h. BPO induced SCEs only at the highest concentration (100 µg/mL) for 48 h treatment. Furthermore, BPO induced CAs at 75 and 100 µg/mL concentrations for 24 h treatment, and at all concentrations for 48 h treatment. BPO induced CAs in a dose-dependent manner for 24 and 48 h treatment periods. Increased level of MN formation induced by BPO was only observed for the 48 h treatment period at the 2 highest concentrations (75 and 100 µg/mL). Statistically significant reductions in the proliferation index (PI) and mitotic index (MI) were only detected in cultures for the 48-h treatment period.

Özet

The aim of the present research was to investigate the genotoxic potency of benzoyl peroxide (BPO), a whitener of flour and cheese, using in vitro sister chromatid exchange (SCE), chromosome aberration (CA), and micronucleus (MN) tests in human peripheral lymphocytes. Cells were exposed to 25, 50, 75, and 100 µg/mL concentrations of BPO for 24 and 48 h. BPO induced SCEs only at the highest concentration (100 µg/mL) for 48 h treatment. Furthermore, BPO induced CAs at 75 and 100 µg/mL concentrations for 24 h treatment, and at all concentrations for 48 h treatment. BPO induced CAs in a dose-dependent manner for 24 and 48 h treatment periods. Increased level of MN formation induced by BPO was only observed for the 48 h treatment period at the 2 highest concentrations (75 and 100 µg/mL). Statistically significant reductions in the proliferation index (PI) and mitotic index (MI) were only detected in cultures for the 48-h treatment period.

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Cite This Article

YAVUZ, A., TOPAKTAŞ, M., *, -., İSTİFLİ, E. S. (2010). In Vitro Genotoxic Effects of Benzoyl Peroxide in Human Peripheral Lymphocytes. Turkish Journal of Biology, Cilt: 34 - Sayı: 1, 15–24. https://ajindex.com/articles/182449

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