Yapay Zeka Hızlı Bakış & Çıkarımlar
AI InsightDWI may provide complementary information for evaluating placental and fetal brain involvement in FGR.
📌 3 Maddede Bu Makale
Abstract
Aims: The aim of this study is to evaluate placental and fetal brain diffusion-weighted imaging (DWI) findings in fetuses with fetal growth restriction (FGR) and to investigate whether placental diffusion abnormalities are accompanied by alterations in fetal brain microstructure. Methods: In this retrospective study, 54 fetuses (25 FGR, 29 controls) who underwent third-trimester fetal magnetic resonance imaging were included. DWI was performed and apparent diffusion coefficient (ADC) values were measured in the placenta (central and peripheral regions) and fetal brain. Group comparisons were performed using appropriate statistical tests, and gestational age (GA)-adjusted analyses were conducted using analysis of covariance. Results: Placental ADC values were significantly lower in the FGR group than controls in both central and peripheral regions (p<0.001 for both), and these differences remained significant after GA adjustment. In the fetal brain, occipital white matter ADC was significantly lower in the FGR group (GA-adjusted p=0.002) and remained significant after Bonferroni correction. Frontal white matter ADC was also lower (GA-adjusted p=0.012), although this difference did not remain significant after multiple-comparison correction. No significant differences were observed in the thalamus, cerebellum, or pons. Placental ADC values were not significantly correlated with GA. Conclusion: FGR is associated with reduced placental ADC values and a region-specific reduction in fetal brain ADC, most notably in the occipital white matter. These findings suggest that placental dysfunction in FGR may be accompanied by early microstructural alterations in the developing fetal brain. DWI may provide complementary information for evaluating placental and fetal brain involvement in FGR.