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Dergiler / Politeknik Dergisi / 2026 / Cilt: 29 Sayı: 2

Transdermal Uygulamalar için Silisyum Karbür Esaslı Sekiz Lümenli Mikroiğnenin Geliştirilmesi ve Karakterizasyonu

Development and Characterization of a Silicon Carbide-Based Eight-Lumen Microneedle for Transdermal Applications

Sema Nur Sahın(ISTANBUL UNIVERSITY-CERRAHPASA)0000-0003-3549-7646
Hamid Asadi Dereshgi(ISTANBUL AREL UNIVERSITY)0000-0002-8500-6625
Yasin Özçelep(ISTANBUL UNIVERSITY-CERRAHPASA)0000-0002-5943-5952
Sayfa
1–12
Yayın Tarihi
2026-03-15
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Akışkan iletimi için dayanıklı ve verimli bir mikroiğne tasarımıyla önemli bir gelişme kaydedilmiş ve bu tasarım, gelecekteki biyomedikal yenilikler için bir ölçüt oluşturmuştur.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Mikroiğneler ilaçların ve biyomoleküllerin etkili ve ağrısız şekilde transdermal iletimini sağlayan biyomedikal uygulamalarda büyük potansiyele sahip gelişmiş cihazlardır.
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Temel Bulgular & Veri:Bu çalışmayla, akışkan akışını optimize etmek ve tıkanıklıkları en aza indirmek amacıyla ucu sekiz lümenle entegre edilmiş ve transdermal tedavinin verimliliği ile güvenilirliğini artıran silisyum karbür tabanlı yeni bir mikroiğne tasarımı önerilmiştir.
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Sonuç & Katkı:Akışkan iletimi için dayanıklı ve verimli bir mikroiğne tasarımıyla önemli bir gelişme kaydedilmiş ve bu tasarım, gelecekteki biyomedikal yenilikler için bir ölçüt oluşturmuştur.
🔬Tür:Modelleme & Sayısal Simülasyon
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Silisyum Karbür · Çoklu Lümenli Mikroiğneler · Akışkan Akışının Optimizasyonu

Özet

Mikroiğneler ilaçların ve biyomoleküllerin etkili ve ağrısız şekilde transdermal iletimini sağlayan biyomedikal uygulamalarda büyük potansiyele sahip gelişmiş cihazlardır. Bu çalışmayla, akışkan akışını optimize etmek ve tıkanıklıkları en aza indirmek amacıyla ucu sekiz lümenle entegre edilmiş ve transdermal tedavinin verimliliği ile güvenilirliğini artıran silisyum karbür tabanlı yeni bir mikroiğne tasarımı önerilmiştir. Çalışmada mikroiğnenin mekanik ve akışkan özellikleri 0.001 hassasiyetle sonlu elemanlar analizi (FEA) kullanılarak incelenmiştir. Analizde su, etanol, kan ve gliserol akışkanları dikkate alınmıştır. Lümenlerdeki maksimum basınçların ortalaması ve toplam debiler, 10 Pa ile 100 Pa arasında 10 Pa artışlarla değişen giriş basınçlarında elde edilmiştir. Lümenlerden elde edilen toplam debiler giriş basıncıyla %99'un üzerinde lineer bir ilişki göstermiştir. Ayrıca mikroiğnenin mekanik davranışı eksenel ve eğilme yükleri altında incelenmiştir. Silisyum karbür ve çoklu lümen yapısı kullanılan bu tasarımın önceki modellere göre mikroiğnenin performansını, mekanik stabilitesini ve akışkan iletim verimliliğini artırdığı gözlenmiştir. Akışkan iletimi için dayanıklı ve verimli bir mikroiğne tasarımıyla önemli bir gelişme kaydedilmiş ve bu tasarım, gelecekteki biyomedikal yenilikler için bir ölçüt oluşturmuştur.

Abstract

Microneedles are advanced devices that ensure efficient, painless transdermal delivery of drugs and biomolecules, with significant potential in biomedical applications. In this study, a novel silicon carbide-based microneedle design was proposed, featuring a tip integrated with eight lumens that optimized fluid flow and minimized blockages, thereby improving the efficiency and reliability of transdermal therapy. The study performed finite element analysis (FEA) of the microneedle with a sensitivity of 0.001, investigating its mechanical and fluidic properties. The analysis considered the fluids water, ethanol, blood, and glycerol. The mean maximum pressures in the lumens and the total flow rates were obtained at inlet pressures ranging from 10 Pa to 100 Pa in 10 Pa increments. The flow rates through the lumens exhibited a near-linear relationship with inlet pressure, maintaining a linearity that exceeded 99%. Additionally, the mechanical behavior of the microneedle was investigated under axial and bending loading. This design, utilizing silicon carbide and a multi-lumen structure, was observed to improve the performance, mechanical stability, and fluid delivery efficiency of the microneedle compared to previous models. A significant advancement was achieved with a durable, efficient microneedle design for fluid delivery, setting a benchmark for future biomedical innovations.

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Bu Makaleye Atıf Yap

Sahın, S. N., Dereshgi, H. A., Özçelep, Y. (2026). Transdermal Uygulamalar için Silisyum Karbür Esaslı Sekiz Lümenli Mikroiğnenin Geliştirilmesi ve Karakterizasyonu. Politeknik Dergisi, Cilt: 29 Sayı: 2, 1–12. https://doi.org/10.2339/politeknik.1601979

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