Dergiler / Yüksek İhtisas Üniversitesi Sağlık Bilimleri Dergisi / 2026 / Cilt: 6 Sayı: 3

Antosiyaninlerin Bağırsak Mikrobiyotası Üzerine Etkisi

Effects of Anthocyanins on the Gut Microbiota

Gülsen Bozdoğan(YÜKSEK İHTİSAS ÜNİVERSİTESİ, SAĞLIK BİLİMLERİ FAKÜLTESİ, BESLENME VE DİYETETİK BÖLÜMÜ)0009-0007-3183-5595
Yeliz Güçer(YÜKSEK İHTİSAS ÜNİVERSİTESİ, SAĞLIK BİLİMLERİ FAKÜLTESİ, BESLENME VE DİYETETİK BÖLÜMÜ)0000-0002-6884-2250
Özlem Muşlu(YÜKSEK İHTİSAS ÜNİVERSİTESİ, SAĞLIK BİLİMLERİ FAKÜLTESİ, BESLENME VE DİYETETİK BÖLÜMÜ)0000-0001-6940-3471
Sayfa
128–133
Yayın Tarihi
2025-12-24
DOI
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Sonuç: Antosiyanin alımının bağırsak mikrobiyotası çeşitliliğinde ve bakteri sayılarında artış sağladığı çeşitli çalışmalarda gösterilmiştir.

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Amaç & Hipotez:Giriş: Antosiyaninler, flavonoidlerin alt grubunda bulunan ve bitkilere başlıca mavi, kırmızı ve mor renklerini veren pigmentlerdir.
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Temel Bulgular & Veri:İlk kez Centaura Cyanus’ta tanımlanmış olmakla birlikte; en çok yaban mersini, siyah üzüm gibi meyvelerde bulunurlar. pH indikatörü olarak da kullanılabilen antosiyaninlerin, doğada 600’ü aşkın türü bulunmaktadır.
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Sonuç & Katkı:Sonuç: Antosiyanin alımının bağırsak mikrobiyotası çeşitliliğinde ve bakteri sayılarında artış sağladığı çeşitli çalışmalarda gösterilmiştir.
🔬Tür:Derleme
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Antosiyaninler · gastrointestinal mikrobiyota · disbiyozis

Özet

Giriş: Antosiyaninler, flavonoidlerin alt grubunda bulunan ve bitkilere başlıca mavi, kırmızı ve mor renklerini veren pigmentlerdir. İlk kez Centaura Cyanus’ta tanımlanmış olmakla birlikte; en çok yaban mersini, siyah üzüm gibi meyvelerde bulunurlar. pH indikatörü olarak da kullanılabilen antosiyaninlerin, doğada 600’ü aşkın türü bulunmaktadır. Antikanser, antienflamatuvar, antimikrobiyal etkilerinin olduğu bilinmekte; bununla birlikte antosiyanin alımının, kardiyovasküler hastalıklar, diyabet, obezite gibi hastalıklarda etkili olabileceği bildirilmektedir. Öte yandan son yıllarda diyetle alınan antosiyaninlerin bağırsak geçirgenliğini önleyebileceği ve mikrobiyota üzerine de olan olumlu etkilerinin bulunduğu keşfedilmiş ve bu açıdan birçok araştırmaya konu olmuştur. Sonuç: Antosiyanin alımının bağırsak mikrobiyotası çeşitliliğinde ve bakteri sayılarında artış sağladığı çeşitli çalışmalarda gösterilmiştir.

Abstract

Introduction: Anthocyanins are pigments belonging to a subgroup of flavonoids that give plants their main blue, red, and purple colors. Although first identified in Centaura cyanus, they are most commonly found in fruits such as blueberries and black grapes. Anthocyanins, which can also be used as pH indicators, have over 600 species in nature. They are known to have anticancer, anti-inflammatory, and antimicrobial effects; furthermore, it is reported that anthocyanin intake may be effective in diseases such as cardiovascular diseases, diabetes, and obesity. On the other hand, in recent years, it has been discovered that dietary anthocyanins can prevent intestinal permeability and have positive effects on the microbiota, and this has been the subject of many studies. Conclusion: Various studies have shown that anthocyanin intake increases the diversity and number of bacteria in the gut microbiota.

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Bu Makaleye Atıf Yap

Bozdoğan, G., Güçer, Y., Muşlu, Ö. (2025). Antosiyaninlerin Bağırsak Mikrobiyotası Üzerine Etkisi. Yüksek İhtisas Üniversitesi Sağlık Bilimleri Dergisi, Cilt: 6 Sayı: 3, 128–133. https://ajindex.com/articles/1647727

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Kaynakça (50)

  1. Koo HE, Azlan A, Tang ST, Lim SM. Anthocyanidins and anthocyanins: colored pigments as food, pharmaceutical. Food Nutr Res. 2017;61(1):1361779. https://doi.org/10.1080/16546628.2017.1361779
  2. Keleş Y. Antosiyanin pigmentlerinin biyokimyası ve analizi. Türk Bilimsel Derlemeler Derg. 2015;1(8):19–25.
  3. Schwinn KE, Davies KM. Flavonoids, in plant pigments and their manipulation, annual plant reviews, Vol 14 (Ed. K Davies). Blackwell Publishing; 2004. pp. 92–149. https://doi.org/10.1002/9781119312994.apr0134
  4. Castañeda-Ovando A, Pacheco-Hernández de L, Páez-Hernández E, Rodríguez JA, Galán-Vidal CA. Chemical studies of anthocyanins: a review. Food Chem. 2009;113:859–871. https://doi.org/10.1016/j.foodchem.2008.09.001
  5. Faria A, Fernandes I, Norberto S, Mateus N, Calhau C. Interplay between anthocyanins and gut microbiota. J Agric Food Chem. 2014;62(29):6898– 6902. https://doi.org/10.1021/jf501808a
  6. Zhong H, Xu J, Yang M, Hussain M, Liu X, Feng F, et al. Protective effect of anthocyanins against neurodegenerative diseases through the microbialintestinal-brain axis: a critical review. Nutrients. 2023;15(3):496. https://doi. org/10.3390/nu15030496
  7. Fairlie-Jones L, Davidson K, Fromentin E, Hill AM. The effect of anthocyaninrich foods or extracts on vascular function in adults: a systematic review and meta-analysis of randomised controlled trials. Nutrients. 2017;9(8):908. https://doi.org/10.3390/nu9080908
  8. Chen K, Kortesniemi MK, Linderborg KM, Yang B. Anthocyanins as Promising Molecules Affecting Energy Homeostasis, inflamation, and gut microbiota in type 2 diabetes with special reference to impact of acylation. J Agric Food Chem. 2023;71(2):1002–1017. https://doi.org/10.1021/acs.jafc.2c05879
  9. Czank C, Cassidy A, Zhang Q, Morrison DJ, Preston T, Kroon PA, et al. Human metabolism and elimination of the anthocyanin, cyanidin-3-glucoside: a C-tracer study. Am J Clin Nutr 2013;97(5):995−1003. https://doi.org/10.3945/ ajcn.112.049247
  10. Sanchez-Patan F, Cueva C, Monagas M, Walton GE, Gibson GRM, QuintanillaLopez JE, et al. In vitro fermentation of a red wine extract by human gut microbiota: changes in microbial groups and formation of phenolic metabolites. J Agric Food Chem. 2012;60(9):2136−2147. https://doi.org/10.1021/jf2040115
  11. Aura A-M, Martin-Lope P, O’Leary KA, Williamson G, Oksman-Caldentey K-M, Poutanen K, et al. In vitro metabolism of anthocyanins by human gut microbiota. Eur J Nutr. 2005;44(3):133–142. https://doi.org/10.1007/s00394- 004-0502-2
  12. Enaru B, Dretcanu G, Pop T, Stanil A, Diaconeasa Z. Anthocyanins: factors affecting their stability and degradation. Antioxidants (Basel). 2021;10(12):1967. https://doi.org/10.3390/antiox10121967
  13. Yang P, Yuan C, Wang H, Han F, Liu Y, Wang L, et al. Stability of anthocyanins and their degradation products from cabernet sauvignon red wine under gastrointestinal ph and temperature conditions. Molecules. 2018;23(2):354. https://doi.org/10.3390/molecules23020354
  14. Stull AJ, Cassidy A, Djousse L, Johnson SA, Krikorian R, Lampe JW, et al. The state of the science on the health benefts of blueberries: a perspective. Front Nutr. 2024;11:1415737. https://doi.org/10.3389/fnut.2024.1415737
  15. Belwal T, Nabavi S, Nabavi S, Habtemariam S. Dietary anthocyanins and insulin resistance: when food becomes a medicine. Nutrients. 2017;9(10):1111. https://doi.org/10.3390/nu9101111
  16. Garcia-Conesa M, Chambers K, Combet E, Pinto P, Garcia-Aloy M, AndresLacueva C, et al. Meta-Analysis of the effects of foods and derived products containing ellagitannins and anthocyanins on cardiometabolic biomarkers: analysis of factors influencing variability of the individual responses. Int J Mol Sci. 2018;19(3):694. https://doi.org/10.3390/ijms19030694
  17. Albuquerque BR, Pinela J, Barros L, Oliveira MBPP, Ferreira ICFR. Anthocyanin-rich extract of jabuticaba epicarp as a natural colorant: Optimization of heat- and ultrasound-assisted extractions and application in a bakery product. Food Chem. 2020;316:126364. https://doi.org/10.1016/j. foodchem.2020.126364
  18. Li J, Ji W, Chen G, Yu K, Zeng J, Zhang Q, et al. Peonidin-3-O-(3,6-Odimalonyl-β-D-glucoside), a polyacylated anthocyanin isolated from the black corncobs, alleviates colitis by modulating gut microbiota in DSS-induced mice. Food Res Int. 2025;202:115688. https://doi.org/10.1016/j.foodres.2025.115688
  19. Qiu M-T, Zhou L, Wang X-Y, Li Z-P, Wei M-X, Zeng Z-H, et al. Anti-colitis comparison of polysaccharides and anthocyanins extracted from black wolfberry based on microbiomics, immunofluorescence and multi-cytokines profle analysis. Int J Biol Macromol. 2025;310(Pt 3):143700. https://doi. org/10.1016/j.ijbiomac.2025.143700
  20. Li J, Wu T, Li N, Wang X, Chen G, Lyu X. Bilberry anthocyanin extract promotes intestinal barrier function and inhibits digestive enzyme activity by regulating the gut microbiota in aging rats. Food Funct. 2019;10(1):333–343. https://doi.org/10.1039/c8fo01962b
  21. Surangi-Dharmawansa KV, Hoskin DW, Vasanta-Rupasin HP. Chemopreventive effect of dietary anthocyanins against gastroinstestinal cancers: a review of recent advances and perspectives. Int J Mol Sci. 2020;21(18):6555. https://doi. org/10.3390/ijms21186555
  22. Thoppil RJ, Bhatia D, Barnes KF, Haznagy-Radnai E, Hohmann J, Darvesh AS, et al. Black currant anthocyanins abrogate oxidative stress through Nrf2-mediated antioxidant mechanisms in a rat model of hepatocellular carcinoma. Curr Cancer Drug Targets. 2012;12(9):1244–1257. https://doi. org/10.2174/156800912803987968
  23. Panchal SK, John OD, Mathai ML, Brown L. Anthocyanins in chronic diseases: the power of purple. Nutrients. 2022;14(10):2161. https://doi.org/10.3390/ nu14102161
  24. Khan MS, Ikram M, Park JS, Park TJ, Kim MO. Gut microbiota, its role in induction of Alzheimer’s disease pathology, and possible therapeutic interventions: Special focus on anthocyanins. Cells. 2020;9(4):853. https://doi. org/10.3390/cells9040853
  25. Zhao Y, Lukiw WJ. Microbiome-generated amyloid and potential impact on amyloidogenesis in Alzheimer’s disease (AD). J Nat Sci. 2015;1(7):e138.
  26. Pistollato F, Cano SS, Elio I, Vergara MM, Giampieri F, Battino M. Role of gut microbiota and nutrients in amyloid formation and pathogenesis of Alzheimer disease. Nutr Rev. 2016;74(10):624–634. https://doi.org/10.1093/nutrit/ nuw023
  27. Hobby GP, Karaduta O, Dusio GF, Singh M, Zybailov BL, Arthur JM. Chronic kidney disease and the gut microbiome. Am J Physiol Renal Physiol. 2019;316(6):F1211–F1217. https://doi.org/10.1152/ajprenal.00298.2018
  28. Sun D, Wang W, Fan Q, Wang X, Xu X, Jiang W, et al. Protective effects of black rice anthocyanins on d-galactose-induced renal injury in mice: the role of nrf2 and nf-κb signaling and gut microbiota modulation. Nutrients. 2025;17(3):502. https://doi.org/10.3390/nu17030502
  29. Li S, Wu B, Fu W, Reddivary L. The anti-inflammatory effects of dietary anthocyanins against ulcerative collitis. Int J Mol Sci. 2019;20(10):2588. https://doi.org/10.3390/ijms20102588
  30. Monk JM, Wu W, Hutchinson AL, Pauls P, Robinson LE, Power KA. Navy and black bean supplementation attenuates colitis-associated inflammation and colonic epithelial damage. J Nutr Biochem. 2018;56:215–223. https://doi. org/10.1016/j.jnutbio.2018.02.013
  31. Tian L, Tan Y, Chen G, Wang G, Sun J, Ou S, et al. Metabolism of anthocyanins and consequent effects on the gut microbiota. Crit Rev Food Sci Nutr. 2019;59(6):982–991. https://doi.org/10.1080/10408398.2018.1533517
  32. Flores G, Ruiz del Castillo A, Costabile A, Klee A, Guergoletto K, Gibson GR. In vitro fermentation of anthocyanins encapsulated with cyclodextrins;Release, metabolism and influence on gut microbiota. J Funct Foods. 2015;16:50–57. http://doi.org/10.1016/j.jff.2015.04.022
  33. Chen L, Jiang B, Zhong C, Guo J, Zhang L, Mu T, et al. Chemoprevention of colorectal cancer by black raspberry anthocyanins involved the modulation of gut microbiota and SFRP2 demethylation. Carcinogenesis. 2018;39(3):471– 481. https://doi.org/10.1093/carcin/bgy009
  34. Li H, Zang M, Tan T, Li S, Mi J, Lu L, et al. Anthocyanins from lycium ruthenicum murray prevent high-fat diet-induced obesity in female mice via gut microbiota-related bile acids metabolism. Natural Product Communications. 2024;19(4):1–15. https://doi.org/10.1177/1934578X241246678
  35. Qiu J, Ye B, Feng L. Improvement of intestinal microbial structure in patients with cerebral infarction through in vitro fermentation of anthocyanins from Lycium ruthenicum Murray. Food Sci Nutr. 2024;12(10):7481–7491. https:// doi.org/10.1002/fsn3.4263
  36. Li X, Wang Y, Jiang Y, Liu C, Zhang W, Chen W, et al. Microencapsulation with fructooligosaccharides and whey protein enhances the antioxidant activity of anthocyanins and their ability to modulate gut microbiota in vitro. Food Res Int. 2024;181:114082. https://doi.org/10.1016/j.foodres.2024.114082
  37. Hou Z, Luan L, Hu X, Chen S, Ye X. Innovative processing technology for enhance potential prebiotic effects of RG-I pectin and cyanidin-3-glucoside. Food Hydrocolloids. 2023;134. https://doi.org/10.1016/j.foodhyd.2022.108045
  38. Morais CA, Vera de Rosso V, Estadella D, Pisani LP. Anthocyanins as inflammatory modulators and the role of the gut microbiota. 2016;33:1–7. https://doi.org/10.1016/j.jnutbio.2015.11.008
  39. Morais CA, Oyama LM, de Morua Conrado R, De Rosso VV, do Nascimento CO, Pisani LP. Polyphenols-rich fruit in maternal diet modulates inflammatory markers and the gut microbiota and improves colonic expression of Z0-1 in offspring. Food Res Int. 2015;77:186–193. https://doi.org/10.1016/j. foodres.2015.06.043
  40. Cheng J, Hu J, Jeng F, Nie S. Bacteroides utilization for dietary polysaccharides and their benef cial effects on gut health. Food Sci Human Wellness. 2022;11(5):1101–1110. https://doi.org/10.1016/j.fshw.2022.04.002
  41. Xu L, Tang Z, Herrera-Balandrano DD, Qiu Z, Li B, Yang Y, et al. In vitro fermentation characteristics of blueberry anthocyanins and their impacts on gut microbiota from obese human. Food Res Int. 2024;176:113761. https://doi. org/10.1016/j.foodres.2023.113761
  42. Dou Z, Chen C, Huang Q, Fu X. In vitro digestion of the whole blackberry fruit: bioaccessibility, bioactive variation of active ingredients and impacts on human gut microbiota. Food Chem. 2022;370:131001. https://doi.org/10.1016/j. foodchem.2021.131001
  43. Groh IAM, Riva A, Braun D, Sutherland HG, Williams O, Bakuradze T, et al. Long-Term consumption of anthocyanin-rich fruit juice: impact on gut microbiota and antioxidant markers in lymphocytes of healthy males. Antioxidants (Basel). 2020;10(1):27. https://doi.org/10.3390/antiox10010027
  44. Huang F, Zhao R, Xia M, Shen GX. Impact of cyanidin-3-glucoside on gut microbiota and relationship with metabolism and inflammation in high fat-high sucrose diet-induced insulin resistant mice. Microorganisms. 2020;8(8):1238. https://doi.org/10.3390/microorganisms8081238
  45. Mi W, Hu Z, Zhao S, Wang W, Lian W, Lu P, et al. Purple sweet potato anthocyanins normalize the blood glucose concentration and restore the gut microbiota in mice with type 2 diabetes mellitus. Heliyon. 2024;10(11):31784. https://doi.org/10.1016/j.heliyon.2024.e31784
  46. Shu C, Wu S, Li H, Tian J. Health benefts of anthocyanin-containing foods, beverages, and supplements have unpredictable relation to gastrointestinal microbiota: A systematic review and meta-analysis of random clinical trials. Nutr Res. 2023;116:48–59. https://doi.org/10.1016/j.nutres.2023.04.002
  47. Hillman AR, Chrismas BCR. Thirty days of Montmorency tart cherry supplementation has no effect on gut microbiome composition, inflammation, or glycemic control in healthy adults. Front Nutr. 2021;8:733057. https://doi. org/10.3389/fnut.2021.733057
  48. Sun D, Wang W, Fan Q, Wang X, Xu X, Jiang W, et al. Protective Effects of Black Rice Anthocyanins on D-Galactose-Induced Renal Injury in Mice: The Role of Nrf2 and NF-κB Signaling and Gut Microbiota Modulation. Nutrients 2025;17(3):502. https://doi.org/10.3390/nu17030502
  49. Santos EF, Sabino YNV, Montenegro EN, Faria Ca, Almedia TC, Gameiro J, et al. Antitumor, anti-inflammatory, and antioxidant activities of anthocyanins from food and isolated sources: Methodological insights and interactions with the intestinal microbiota. Journal of Functional Foods 2025;134:107026. https://doi.org/10.1016/j.jff.2025.107026
  50. Alnajjar M, Barik SK, Bestwick C, Campbell F, Cruickshank M, Farquharson F, et al. Anthocyanin-enriched bilberry extract attenuates glycaemic response in overweight volunteers without changes in insulin. J Funct Foods 2020;64:103597. https://doi.org/10.1016/j.jff.2019.103597