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Dergiler / Recent Trends in Pharmacology / 2025 / Volume: 3 Issue: 3

A Drug Repositioning Approach: Antidiabetic Empagliflozin May Be a Potential Drug for the Treatment of ALS

Selma Sezen(AĞRI İBRAHİM ÇEÇEN ÜNİVERSİTESİ, TIP FAKÜLTESİ, DAHİLİ TIP BİLİMLERİ BÖLÜMÜ, TIBBİ FARMAKOLOJİ ANABİLİM DALI)0000-0001-6575-6149
Feyza Burul(AĞRI İBRAHİM ÇEÇEN ÜNİVERSİTESİ, TIP FAKÜLTESİ, DAHİLİ TIP BİLİMLERİ BÖLÜMÜ, TIBBİ FARMAKOLOJİ ANABİLİM DALI)0009-0002-2193-1106
Sayfa
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Yayın Tarihi
2026-01-15
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Conclusion: In this study, conducted to repurpose empagliflozin via ALS-related mechanisms, which has been reported to have cardioprotective, hepatoprotective, and renoprotective effects in clinical studies, the findings obtained using computational models suggest that empagliflozin may have neuroprotective effects in ALS.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Objective: Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease in which multiple mechanisms play a role in its pathogenesis.
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Temel Bulgular & Veri:For molecular docking analyses, the 3D structures of these ALS-associated receptors SOD1 (2C9V), hnRNP A1 (1HA1), TDP-43 (4BS2), SQSTM1/p62 (5YP7) were obtained from the RCSB Protein Data Bank.
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Sonuç & Katkı:Conclusion: In this study, conducted to repurpose empagliflozin via ALS-related mechanisms, which has been reported to have cardioprotective, hepatoprotective, and renoprotective effects in clinical studies, the findings obtained using computational models suggest that empagliflozin may have neuroprotective effects in ALS.
🔬Tür:Modelleme & Sayısal Simülasyon
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:ALS · empagliflozin · molecular docking

Abstract

Objective: Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease in which multiple mechanisms play a role in its pathogenesis. However, no radical treatment is currently available for the disease. The potential for repositioning of the antidiabetic drug empagliflozin, which has been reported to have neuroprotective effects in recent studies, in ALS was investigated using computational models. Methods: In this study, to identify ALS-related target proteins, protein–protein interaction networks and disease–gene enrichment analysis were constructed using the STRING database. For molecular docking analyses, the 3D structures of these ALS-associated receptors SOD1 (2C9V), hnRNP A1 (1HA1), TDP-43 (4BS2), SQSTM1/p62 (5YP7) were obtained from the RCSB Protein Data Bank. Empagliflozin and the receptors were prepared using UCSF Chimera v1.19 and AutoDockTools 1.5.7, and binding scores were recorded with AutoDock Vina. The ADMET properties of empagliflozin were determined using ADMETlab 2.0 and LogBB_Pred. Results: In the protein networks generated by STRING, ALS-related proteins with high confidence scores and physical interactions were identified, and among them, four target proteins showing significant interactions and with available PDB codes were selected. Molecular docking analyses revealed that empagliflozin exhibited moderate-to-high binding interactions with SOD1 (-8.5 kcal/mol), TDP-43 (-7.7 kcal/mol), hnRNP A1 (-7.3 kcal/mol), and SQSTM1/p62 (-7.1 kcal/mol). According to ADMET analysis, empagliflozin can cross the blood–brain barrier, has a low risk of hepatotoxicity, and shows potential interactions with androgen receptor and aromatase. Conclusion: In this study, conducted to repurpose empagliflozin via ALS-related mechanisms, which has been reported to have cardioprotective, hepatoprotective, and renoprotective effects in clinical studies, the findings obtained using computational models suggest that empagliflozin may have neuroprotective effects in ALS.

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Bu Makaleye Atıf Yap

Sezen, S., Burul, F. (2026). A Drug Repositioning Approach: Antidiabetic Empagliflozin May Be a Potential Drug for the Treatment of ALS. Recent Trends in Pharmacology, Volume: 3 Issue: 3. https://doi.org/10.62425/rtpharma.1828403

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