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Dergiler / Recent Trends in Pharmacology / 2026 / Volume: 4 Issue: 1

Evaluation of the Antidepressant Potential of Triplochiton scleroxylon Leaf Extract Using Tail Suspension and Forced Swim Tests

Albashir Tahir(Department of Pharmacology, Faculty of Basic Medical Sciences, Sa’adu Zungur University, Bauchi State, Nigeria)0000-0001-9272-5540
Khadija Abdullahi Kobi(Department of Nursing Science, Faculty of Allied Health Sciences, Abubakar Tafawa Balewa University, Bauchi State, Nigeria)0009-0007-1409-7674
Abbas Nasidi(Department of Anatomy, Faculty of Basic Medical Sciences, Sa’adu Zungur University, Bauchi State, Nigeria)0000-0002-7167-7671
Nura Bello(Department of Pharmacology and Therapeutics, Faculty of Pharmaceutical Sciences, Ahmadu Bello University Zaria, Kaduna State, Nigeria)0000-0002-0928-8261
Sayfa
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Yayın Tarihi
2026-04-24
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Keywords: Triplochiton scleroxylon, depression, antidepressant, phytochemicals, tail suspension test, forced swim test.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Objective: Depression is a major neuropsychiatric disorder with a substantial global burden.
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Temel Bulgular & Veri:Methods: Fresh leaves of T. scleroxylon were extracted by ethanol maceration, yielding 14.4% crude extract.
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Sonuç & Katkı:Keywords: Triplochiton scleroxylon, depression, antidepressant, phytochemicals, tail suspension test, forced swim test.
🔬Tür:Modelleme & Sayısal Simülasyon
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Antidepressant · Depression · Forced Swim Test

Abstract

Objective: Depression is a major neuropsychiatric disorder with a substantial global burden. Existing pharmacotherapies are limited by delayed onset of action, incomplete response, and adverse effects, necessitating the exploration of alternative therapeutic agents, particularly from medicinal plants. Triplochiton scleroxylon was selected based on its ethnomedicinal use and reported richness in bioactive phytochemicals with potential neuropharmacological activity. This study evaluated the antidepressant-like activity, phytochemical composition, and acute toxicity profile of the ethanol leaf extract of T. scleroxylon in murine models. Methods: Fresh leaves of T. scleroxylon were extracted by ethanol maceration, yielding 14.4% crude extract. Preliminary phytochemical screening was conducted using standard qualitative methods. Acute toxicity was assessed using Lorke’s method. Antidepressant-like activity was evaluated in mice (n=4 per group) using the Tail Suspension Test (TST) and Forced Swim Test (FST). Animals received oral doses of 22.5, 45, and 90 mg/kg extract, with imipramine (10 mg/kg) as the reference drug. Results: Phytochemical analysis revealed the presence of flavonoids, alkaloids, tannins, saponins, and steroids. No mortality was observed at 10 and 100 mg/kg in the acute toxicity study, while mortality occurred at 1000 mg/kg. In both TST and FST models, the extract significantly reduced immobility time at 45 and 90 mg/kg in a dose-dependent manner (p<.05). Conclusion: The ethanol leaf extract of T. scleroxylon exhibits significant dose-dependent antidepressant-like activity with a favorable safety margin, supporting its potential as a source of bioactive compounds for antidepressant drug development. Keywords: Triplochiton scleroxylon, depression, antidepressant, phytochemicals, tail suspension test, forced swim test.

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Bu Makaleye Atıf Yap

Tahir, A., Kobi, K. A., Nasidi, A., Bello, N. (2026). Evaluation of the Antidepressant Potential of Triplochiton scleroxylon Leaf Extract Using Tail Suspension and Forced Swim Tests. Recent Trends in Pharmacology, Volume: 4 Issue: 1. https://doi.org/10.62425/rtpharma.1897763

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