KaydedilenlerDerginizi ekleyin

Dergiler / Ağrı Tıp Fakültesi Dergisi / 2026 / Cilt: 4 Sayı: 3

Epileptogenezde nöroinflamatuvar ağlar: mikroglia-astrosit-nöron etkileşimleri

Neuroinflammatory networks in epileptogenesis: microglia-astrocyte-neuron interactions

Fümet Duygu Üstündağ(AĞRI İBRAHİM ÇEÇEN ÜNİVERSİTESİ, TIP FAKÜLTESİ, TEMEL TIP BİLİMLERİ BÖLÜMÜ, BİYOFİZİK ANABİLİM DALI)0000-0001-5290-8924
Ünsal Veli Üstündağ(AĞRI İBRAHİM ÇEÇEN ÜNİVERSİTESİ, TIP FAKÜLTESİ, TEMEL TIP BİLİMLERİ BÖLÜMÜ, TIBBİ BİYOKİMYA ANABİLİM DALI)0000-0003-0804-1475
Sayfa
95–98
Yayın Tarihi
2026-10-02
🏛️Bu makalenin bibliyografik verileri ve tam metin bağlantısı DergiPark üzerinden sağlanmıştır.
DergiPark Kaydı ↗
✨

Yapay Zeka Hızlı Bakış & Çıkarımlar

AI Insight
⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

According to the journal rules, an abstract is not required for the Editorial article type.

📌 3 Maddede Bu Makale

🎯
Amaç & Hipotez:According to the journal rules, an abstract is not required for the Editorial article type.
📊
Temel Bulgular & Veri:According to the journal rules, an abstract is not required for the Editorial article type.
💡
Sonuç & Katkı:According to the journal rules, an abstract is not required for the Editorial article type.
🔬Tür:Editoryal
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Epilepsi · nöroinflamasyon · mikroglia

Özet

According to the journal rules, an abstract is not required for the Editorial article type.

Abstract

According to the journal rules, an abstract is not required for the Editorial article type.

🔖

Bu Makaleye Atıf Yap

Üstündağ, F. D., Üstündağ, Ü. V. (2026). Epileptogenezde nöroinflamatuvar ağlar: mikroglia-astrosit-nöron etkileşimleri. Ağrı Tıp Fakültesi Dergisi, Cilt: 4 Sayı: 3, 95–98. https://doi.org/10.61845/agrimedical.2033104

📄 Tam Metin PDF Okuyucu

📄

PDF görüntüleyici hazırlanıyor...

Kaynakça (25)

  1. Erisken S, Nune G, Chung H, Kang JW, Koh S. Time and age dependent regulation of neuroinflammation in a rat model of mesial temporal lobe epilepsy: correlation with human data. Front Cell Dev Biol. 2022;10:969364. https://doi.org/10.3389/fcell.2022.969364
  2. Patel DC, Thompson EG, Sontheimer H. Brain-derived neurotrophic factor inhibits the function of cation-chloride cotransporter in a mouse model of viral infection-induced epilepsy. Front Cell Dev Biol. 2022;10:961292. https://doi.org/10.3389/fcell.2022.961292
  3. Chen Y, Nagib MM, Yasmen N, Sluter MN, Littlejohn TL, Yu Y, et al. Neuroinflammatory mediators in acquired epilepsy: an update. Inflamm Res. 2023;72(4):683-701. https://doi.org/10.1007/s00011-023-01700-8
  4. Arias-Carrión O, Rodríguez de Ita J, Yu P. Innate immune signalling, neuroinflammation and network plasticity in temporal lobe epilepsy. Front Pharmacol. 2026;17:1770964. https://doi.org/10.3389/fphar.2026.1770964
  5. Sano F, Shigetomi E, Shinozaki Y, Tsuzukiyama H, Saito K, Mikoshiba K, et al. Reactive astrocyte-driven epileptogenesis is induced by microglia initially activated following status epilepticus. JCI Insight. 2021;6(9):e135391. https://doi.org/10.1172/jci.insight.135391
  6. Paudel YN, Angelopoulou E, Akyuz E, Piperi C, Othman I, Shaikh MF. Role of innate immune receptor TLR4 and its endogenous ligands in epileptogenesis. Pharmacol Res. 2020;160:105172. https://doi.org/10.1016/j.phrs.2020.105172
  7. Zhang S, Chen F, Zhai F, Liang S. Role of HMGB1/TLR4 and IL-1β/IL-1R1 signaling pathways in epilepsy. Front Neurol. 2022;13:904225. https://doi.org/10.3389/fneur.2022.904225
  8. Viviani B, Bartesaghi S, Gardoni F, Vezzani A, Behrens MM, Bartfai T, et al. Interleukin-1β enhances NMDA receptor-mediated intracellular calcium increase through activation of the Src family of kinases. J Neurosci. 2003;23(25):8692-700. https://doi.org/10.1523/JNEUROSCI.23-25-08692.2003
  9. Roseti C, van Vliet EA, Cifelli P, Ruffolo G, Baayen JC, Di Castro MA, et al. GABAA currents are decreased by IL-1β in epileptogenic tissue of patients with temporal lobe epilepsy: implications for ictogenesis. Neurobiol Dis. 2015;82:311-20. https://doi.org/10.1016/j.nbd.2015.07.003
  10. Olmos G, Lladó J. Tumor necrosis factor alpha: a link between neuroinflammation and excitotoxicity. Mediators Inflamm. 2014;2014:861231. https://doi.org/10.1155/2014/861231
  11. Stellwagen D, Beattie EC, Seo JY, Malenka RC. Differential regulation of AMPA receptor and GABA receptor trafficking by tumor necrosis factor-alpha. J Neurosci. 2005;25(12):3219-28. https://doi.org/10.1523/JNEUROSCI.4486-04.2005
  12. Meng XF, Tan L, Tan MS, Jiang T, Tan CC, Li MM, et al. Inhibition of the NLRP3 inflammasome provides neuroprotection in rats following amygdala kindling-induced status epilepticus. J Neuroinflammation. 2014;11:212. https://doi.org/10.1186/s12974-014-0212-5
  13. Green JL, Dos Santos WF, Fontana ACK. Role of glutamate excitotoxicity and glutamate transporter EAAT2 in epilepsy: opportunities for novel therapeutics development. Biochem Pharmacol. 2021;193:114786. https://doi.org/10.1016/j.bcp.2021.114786
  14. Patel DC, Tewari BP, Chaunsali L, Sontheimer H. Neuron-glia interactions in the pathophysiology of epilepsy. Nat Rev Neurosci. 2019;20(5):282-97. https://doi.org/10.1038/s41583-019-0126-4
  15. Cacheaux LP, Ivens S, David Y, Lakhter AJ, Bar-Klein G, Shapira M, et al. Transcriptome profiling reveals TGF-beta signaling involvement in epileptogenesis. J Neurosci. 2009;29(28):8927-35. https://doi.org/10.1523/JNEUROSCI.0430-09.2009
  16. Weissberg I, Wood L, Kamintsky L, Vazquez O, Milikovsky DZ, Alexander A, et al. Albumin induces excitatory synaptogenesis through astrocytic TGF-β/ALK5 signaling in a model of acquired epilepsy following blood-brain barrier dysfunction. Neurobiol Dis. 2015;78:115-25. https://doi.org/10.1016/j.nbd.2015.02.029
  17. Bar-Klein G, Cacheaux LP, Kamintsky L, Prager O, Weissberg I, Schoknecht K, et al. Losartan prevents acquired epilepsy via TGF-β signaling suppression. Ann Neurol. 2014;75(6):864-75. https://doi.org/10.1002/ana.24147
  18. Ravizza T, Scheper M, Di Sapia R, Gorter JA, Aronica E, Vezzani A. mTOR and neuroinflammation in epilepsy: implications for disease progression and treatment. Nat Rev Neurosci. 2024;25(5):334-50. https://doi.org/10.1038/s41583-024-00805-1
  19. Zhao XF, Liao Y, Alam MM, Mathur R, Feustel P, Mazurkiewicz JE, et al. Microglial mTOR is neuronal protective and antiepileptogenic in the pilocarpine model of temporal lobe epilepsy. J Neurosci. 2020;40(40):7593-608. https://doi.org/10.1523/JNEUROSCI.2754-19.2020
  20. Xu Y, Zhang M, Zhou K, Wang L. Single-cell dissection of the SPP1-CD44 axis reveals microglia-astrocyte crosstalk driving neuroinflammation in temporal lobe epilepsy. Mol Neurobiol. 2026;63(1):376. https://doi.org/10.1007/s12035-026-05688-0
  21. Wyatt SK, Witt T, Barbaro NM, Cohen-Gadol AA, Brewster AL. Enhanced classical complement pathway activation and altered phagocytosis signaling molecules in human epilepsy. Exp Neurol. 2017;295:184-93. https://doi.org/10.1016/j.expneurol.2017.06.009
  22. Jeong Y, Lim HK, Kim H, Lee J, Lee S, Suh M. C1q neutralization during epileptogenesis attenuates complement-mediated synaptic elimination and epileptiform activity. Epilepsia. 2026;67(2):908-22. https://doi.org/10.1111/epi.18678
  23. Zhang X, Liang P, Zhang Y, Wu Y, Song Y, Wang X, et al. Blockade of Kv1.3 potassium channel inhibits microglia-mediated neuroinflammation in epilepsy. Int J Mol Sci. 2022;23(23):14693. https://doi.org/10.3390/ijms232314693
  24. Chen J, Gao Y, Liu N, Hai D, Wei W, Liu Y, et al. Mechanism of NLRP3 inflammasome in epilepsy and related therapeutic agents. Neuroscience. 2024;546:157-77. https://doi.org/10.1016/j.neuroscience.2024.03.029
  25. Aguilar-Castillo MJ, Cabezudo-García P, García-Martín G, Lopez-Moreno Y, Estivill-Torrús G, Ciano-Petersen NL, et al. A systematic review of the predictive and diagnostic uses of neuroinflammation biomarkers for epileptogenesis. Int J Mol Sci. 2024;25(12):6488. https://doi.org/10.3390/ijms25126488