KaydedilenlerDerginizi ekleyin

Dergiler / Eurasian Journal of Toxicology / 2023 / Volume: 5 Issue: 3

“Paraquat Brain”: Have We Researched Enough?

Ananth Rupesh Kattamreddy(Andhra Medical College)0000-0003-1525-3740
Mohit Kumar Moses Thathapudi(Andhra Medical College)0000-0003-4524-8387
Victor Ghosh(Andhra Medical College)0000-0003-0914-1056
Jacinth Karunya Midde(GITAM University)0009-0003-3224-3533
Pravin Kalyankar(Fortis Escorts Hospital)0000-0002-6187-8138
Sayfa
—
Yayın Tarihi
2023-12-31
🏛️Bu makalenin bibliyografik verileri ve tam metin bağlantısı DergiPark üzerinden sağlanmıştır.
DergiPark Kaydı ↗
✨

Yapay Zeka Hızlı Bakış & Çıkarımlar

AI Insight
⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

The pursuit of understanding the PQ-PD connection necessitates unwavering commitment from the scientific community.

📌 3 Maddede Bu Makale

🎯
Amaç & Hipotez:This letter examines the potential relationship between the highly toxic herbicide paraquat (PQ) and Parkinson's disease (PD).
📊
Temel Bulgular & Veri:Despite animal studies implicating PQ as a causative factor for PD, the evidence is insufficient due to limited human research on this topic.
💡
Sonuç & Katkı:The pursuit of understanding the PQ-PD connection necessitates unwavering commitment from the scientific community.
🔬Tür:Review
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Paraquat · parkinson's disease · toxicology

Abstract

This letter examines the potential relationship between the highly toxic herbicide paraquat (PQ) and Parkinson's disease (PD). Despite animal studies implicating PQ as a causative factor for PD, the evidence is insufficient due to limited human research on this topic. There is a pressing need for human autopsy-based studies in PQ poisoning fatalities to comprehend paraquat's neuropathology. Further studies are crucial to assess the morbidity in paraquat poisoning survivors, potentially shedding light on clinical links with PD. Although current research hasn't definitively established a causal connection, the absence of evidence shouldn't discourage ongoing investigation. The pursuit of understanding the PQ-PD connection necessitates unwavering commitment from the scientific community.

🔖

Bu Makaleye Atıf Yap

Kattamreddy, A. R., Thathapudi, M. K. M., Ghosh, V., Midde, J. K., Kalyankar, P. (2023). “Paraquat Brain”: Have We Researched Enough?. Eurasian Journal of Toxicology, Volume: 5 Issue: 3. https://doi.org/10.51262/ejtox.1344451

📄 Tam Metin PDF Okuyucu

📄

PDF görüntüleyici hazırlanıyor...

Kaynakça (20)

  1. Gao L, Yuan H, Xu E, Liu J. Toxicology of paraquat and pharmacology of the protective effect of 5-hydroxy-1-methylhydantoin on lung injury caused by paraquat based on metabolomics. Sci Rep 2020;10. https://doi.org/10.1038/s41598-020-58599-y
  2. Shanbhag V, Sukumar CA, Shastry AB. Paraquat: The poison potion. Indian J Crit Care Med 2019;23:0–0. https://doi.org/10.5005/jp-journals-10071-23306.
  3. Suntres Z. Role of antioxidants in paraquat toxicity. Toxicology 2002;180:65–77. https://doi.org/10.1016/s0300-483x(02)00382-7.
  4. Dinis-Oliveira RJ, Duarte JA, Sánchez-Navarro A, Remião F, Bastos ML, Carvalho F. Paraquat poisonings: Mechanisms of lung toxicity, clinical features, and treatment. Crit Rev Toxicol 2008;38:13–71. https://doi.org/10.1080/10408440701669959.
  5. Delirrad M, Majidi M, Boushehri B. Clinical features, and prognosis of paraquat poisoning: a review of 41 cases. Int J Clin Exp Med 2015;8:8122–8.
  6. Delirrad M, Majidi M, Boushehri B. Clinical features and prognosis of paraquat poisoning: a review of 41 cases. Int J Clin Exp Med. 2015;8(5):8122–8.
  7. Wang X, Wang X, Zhu Y, Chen X. ADME/T-based strategies for paraquat detoxification: Transporters and enzymes. Environ Pollut 2021;291:118137. https://doi.org/10.1016/j.envpol.2021.118137.
  8. Vaccari C, El Dib R, Gomaa H, Lopes LC, de Camargo JL. Paraquat and Parkinson’s disease: a systematic review and meta-analysis of observational studies. J Toxicol Environ Health B Crit Rev 2019;22:172–202. https://doi.org/10.1080/10937404.2019.1659197.
  9. Tangamornsuksan W, Lohitnavy O, Sruamsiri R, Chaiyakunapruk N, Norman Scholfield C, Reisfeld B, et al. Paraquat exposure and Parkinson’s disease: A systematic review and meta-analysis. Arch Environ Occup Health 2019;74:225–38. https://doi.org/10.1080/19338244.2018.1492894.
  10. Briñez-Gallego P, da Costa Silva DG, Cordeiro MF, Horn AP, Hort MA. Experimental models of chemically induced Parkinson’s disease in zebrafish at the embryonic larval stage: a systematic review. J Toxicol Environ Health B Crit Rev 2023;26:201–37. https://doi.org/10.1080/10937404.2023.2182390.
  11. Lama J, Buhidma Y, Fletcher EJR, Duty S. Animal models of Parkinson’s disease: a guide to selecting the optimal model for your research. Neuronal Signal 2021;5. https://doi.org/10.1042/ns20210026.
  12. Uversky VN. Neurotoxicant-induced animal models of Parkinson’s disease: understanding the role of rotenone, maneb and paraquat in neurodegeneration. Cell Tissue Res 2004;318:225–41. https://doi.org/10.1007/s00441-004-0937-z.
  13. Cicchetti F, Lapointe N, Roberge-Tremblay A, Saint-Pierre M, Jimenez L, Ficke BW, et al. Systemic exposure to paraquat and maneb models early Parkinson’s disease in young adult rats. Neurobiol Dis 2005;20:360–71.
  14. Soontornniyomkij V, Bunyaratvej S. Fatal paraquat poisoning: a light microscopic study in eight autopsy cases. J Med Assoc Thai 1992;75 Suppl 1:98–105.
  15. Mukada T, Sasano N, Sato K. Autopsy findings in a case of acute paraquat poisoning with extensive cerebral purpura. Tohoku J Exp Med 1978;125:253–63. https://doi.org/10.1620/tjem.125.253.
  16. Hughes JT. Brain damage due to Paraquat poisoning: a fatal case with neuropathological examination of the brain. Neurotoxicology Park For South. 1988;9(2):243–8.
  17. Jovic-Stosic J, Babic G, Todorovic V. Fatal diquat intoxication. Vojnosanit Pregl 2009;66:477–81. https://doi.org/10.2298/vsp0906477j.
  18. Demonstrated at the Division of Medicine (Clinical) Royal Infirmary, Edinburgh., Matthew H. Paraquat poisoning: clinicopathological conference. Scott Med J 1971;16:407–21. https://doi.org/10.1177/003693307101600905.
  19. von der Hardt, H., Cardesa, A. Early histopathological changes after paraquat intoxication. Klin Wochenschr 49, 544–550 (1971). https://doi.org/10.1007/BF01487992
  20. Paraquat. Safety - Humans: Paraquat and Parkinson's Disease [Internet]. Paraquat; [cited 2023 Aug 15]. Available from: https://www.paraquat.com/en/safety/safety-humans/paraquat-and-parkinsons-disease