Serum Levels of Interleukin (IL)-lp, sIL-2R, IL-6, IL-8 and TNF-a in Chüdren with idiopatine Nephrotic Syndrome

Özet

SüleymanDemirel Üniversitesi TIP FAKÜLTESİ DERGİSİ: 1999 Haziran; 6(2) Serum Levels of Interleukin (IL)-lp, sIL-2R, IL-6, IL-8 and TNF-a in Chüdren with idiopatine Nephrotic Syndrome Aydın Ece, Leyla Çolpan, Mehmet Emin Yılmaz, Fuat Gürkan, Kenan Haspolat Abstract The pathogenesis of idiopathic nephrotic syndrome (INS) is stili controversial. Lymphocytic dysfunction and increased cytokine prodıtction have been suggested to be pathogenetic mechanism for renal injury in childhood INS. in order to investigate the role of certain cytokines, 23 children with steroid sensitive INS, aged 2-8 years, and 29 healthy controls were included in the study. Blood samples ofpatients were taken both at remission and relapse phases of the disease. Cytokines were measured by the chemiluminescent immunometric assay. Interleukin (lL)-l/3 vvas undetectable in serum samples of ali children. Serum levels of soluble interleukin-2 receptor (sIL-2R), IL-6, IL-8, and tümör necrosis factor-alpha (TNF-a) vere signifıcantly higher in relapsing phase of INS compared to remission and controls. Signifıcant correlation wasfound between sIL-2R and 24-hour proteinuria. in conclusion, sIL-2R, IL-6, IL-8 and TNF-a may have a role in the pathogenesis of renal injury in childhood steroid sensitive INS. Key Words: Children, cytokines, nephrotic syndrome, pathogenesis