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Dergiler / SDÜ Tıp Fakültesi Dergisi / 2026 / Cilt: 31 Sayı: 3

An Essential Problem in Patients with Hereditary Angioedema: Irritable Bowel Syndrome

Mehmet Kılınç(BATMAN EĞİTİM VE ARAŞTIRMA HASTANESİ)0000-0003-1117-6872
Fatih Çölkesen(NECMETTİN ERBAKAN ÜNİVERSİTESİ, MERAM TIP FAKÜLTESİ)0000-0002-6595-1267
Filiz Sadi Aykan(SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, GÜLHANE TIP FAKÜLTESİ, GÜLHANE TIP PR. (ANKARA))0000-0002-8941-5573
Recep Evcen(RECEP TAYYİP ERDOĞAN ÜNİVERSİTESİ, TIP FAKÜLTESİ)0000-0002-6124-5816
Eray Yıldız(NECİP FAZIL ŞEHİR HASTANESİ, İMMÜNOLOJİ VE ALERJİ HASTALIKLARI BÖLÜMÜ)0000-0002-9596-1773
Tuğba Önalan(NECMETTİN ERBAKAN ÜNİVERSİTESİ, MERAM TIP FAKÜLTESİ)0000-0003-2427-5925
Mehmet Emin Gerek(NECMETTİN ERBAKAN ÜNİVERSİTESİ, MERAM TIP FAKÜLTESİ)0000-0003-4792-0544
Şevket Arslan(NECMETTİN ERBAKAN ÜNİVERSİTESİ, MERAM TIP FAKÜLTESİ)0000-0002-0343-0159
Sayfa
229–234
Yayın Tarihi
2024-09-29
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Conclusion: Clinicians should keep HAE in mind in patients with suspected IBS or patients presenting with recurrent unexplained abdominal pain.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Objective: Hereditary angioedema (HAE) is characterized by attacks of subcutaneous and mucosal edema.
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Temel Bulgular & Veri:Material and Method: 50 patients with HAE followed in our clinic between January 2013 and April 2023 were included in this study, and hospital records were retrospectively reviewed.
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Sonuç & Katkı:Conclusion: Clinicians should keep HAE in mind in patients with suspected IBS or patients presenting with recurrent unexplained abdominal pain.
🔬Tür:Literatür & Derleme Çalışması
📍Kapsam:2013 Verileri
⚙️Değişkenler:Hereditary angioedema · irritable bowel syndrome · abdominal symptoms

Abstract

Objective: Hereditary angioedema (HAE) is characterized by attacks of subcutaneous and mucosal edema. HAE usually affects the skin or mucosal tissues of the upper respiratory and gastrointestinal tract. Irritable bowel syndrome (IBS) is one of the diseases in which the abdominal symptoms of HAE may be confused. In this study, we aimed to clarify the role of IBS in clinical presentation and diagnostic delay in HAE. Material and Method: 50 patients with HAE followed in our clinic between January 2013 and April 2023 were included in this study, and hospital records were retrospectively reviewed. Patients with HAE were divided into two groups, those with and without IBS, and evaluated according to Rome IV criteria for diagnosing IBS. Results: The mean age of the study group was 40 ± 13 years, and 60% (n=30) were female. IBS was observed in 30% (n=15) of the patients, and 60% (n=9) had IBS before diagnosing HAE. The frequency of attacks and history of gastrointestinal tract medical/surgical history were more frequent in HAE patients with IBS (p<0.001, p=0.032, respectively). Abdominal symptoms before the diagnosis of HAE and persistent abdominal symptoms other than attacks after the diagnosis of HAE were more common in HAE patients with IBS (p<0.001, p<0.001, respectively). HAE patients with IBS had a more significant delay in diagnosing HAE (p=0.011). Conclusion: Clinicians should keep HAE in mind in patients with suspected IBS or patients presenting with recurrent unexplained abdominal pain.

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Bu Makaleye Atıf Yap

Kılınç, M., Çölkesen, F., Aykan, F. S., Evcen, R., Yıldız, E., Önalan, T., Gerek, M. E., Arslan, Ş. (2024). An Essential Problem in Patients with Hereditary Angioedema: Irritable Bowel Syndrome. SDÜ Tıp Fakültesi Dergisi, Cilt: 31 Sayı: 3, 229–234. https://doi.org/10.17343/sdutfd.1457010

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