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Dergiler / SDÜ Tıp Fakültesi Dergisi / 2026 / Cilt: 32 Sayı: 2

Assessment of Gallbladder Epithelial Lesions and Clinicopathological High-Risk Patient

Özden Öz(İZMİR DEMOKRASİ ÜNİVERSİTESİ, TIP FAKÜLTESİ)0000-0001-5601-1567
Abdullah İnal(İZMİR DEMOKRASİ ÜNİVERSİTESİ, TIP FAKÜLTESİ)0000-0001-9124-6011
Sayfa
177–183
Yayın Tarihi
2025-06-19
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

We argue that taking additional macroscopic samples would be more effective in the definitive diagnosis of gallbladder epithelial pathologies in this age group, and being more careful when deciding on the indication for cholecystectomy in the over-50 age group.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Objective: Recognizing epithelial pathologies in the gallbladder and understanding the accompanying clinicopathological features may be useful in determining the decision for cholecystectomy.
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Temel Bulgular & Veri:Materials and Methods: We designed a retrospective cross-sectional study in which we re-evaluated Hematoxylin & Eosin-stained slides of 852 cholecystectomy materials operated in our hospital for two years.
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Sonuç & Katkı:We argue that taking additional macroscopic samples would be more effective in the definitive diagnosis of gallbladder epithelial pathologies in this age group, and being more careful when deciding on the indication for cholecystectomy in the over-50 age group.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Gallbladder · Mucosal pathologies · Cholecystectomy

Abstract

Objective: Recognizing epithelial pathologies in the gallbladder and understanding the accompanying clinicopathological features may be useful in determining the decision for cholecystectomy. However, this distinctive selection in gallbladder patients has not been fully elucidated yet. In our series, we aimed to investigate the relationship between epithelial pathologies of the mucosa and clinicopathological findings in cholecystectomy materials and evaluate them in the light of the literature. Materials and Methods: We designed a retrospective cross-sectional study in which we re-evaluated Hematoxylin & Eosin-stained slides of 852 cholecystectomy materials operated in our hospital for two years. Mucosal pathologies were grouped as papillary hyperplasia (PH), pyloric metaplasia (PM), intestinal metaplasia (IM), epithelial dysplasia (ED), and cancer. We obtained the demographic data from the electronic archive system of our hospital. The chi-square test and Fisher’s exact test were used, and p <0.05 was considered significant. Results: The mean age of the patient was 53.17 ± 13.48. PH, PM, IM, PM+IM, ED, and invasive cancer were detected in 11.38%, 8.92%, 11.15%, 07.04%, 3.16%, and 0.47% of all cases, respectively. The mucosal pathologies were mostly observed over 50 years (p <0,05). The mass-forming lesion could not be detected among dysplasia cases (p <0.0001). Conclusions: Age was found to be an essential factor for gallbladder epithelial changes in our study. We argue that taking additional macroscopic samples would be more effective in the definitive diagnosis of gallbladder epithelial pathologies in this age group, and being more careful when deciding on the indication for cholecystectomy in the over-50 age group.

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Bu Makaleye Atıf Yap

Öz, Ö., İnal, A. (2025). Assessment of Gallbladder Epithelial Lesions and Clinicopathological High-Risk Patient. SDÜ Tıp Fakültesi Dergisi, Cilt: 32 Sayı: 2, 177–183. https://doi.org/10.17343/sdutfd.1615328

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