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Dergiler / Medical Records / 2026 / Cilt: 5 Sayı: 2

Rosmarinic Acid Ameliorates Deltamethrin Induced Hepatotoxicity and Nephrotoxicity

Eda Yildizhan(DİCLE ÜNİVERSİTESİ)0000-0002-5648-6498
Burak Veli Ülger(DİCLE ÜNİVERSİTESİ, TIP FAKÜLTESİ)0000-0001-9843-6301
Murat Akkuş(DİCLE ÜNİVERSİTESİ, TIP FAKÜLTESİ)0000-0002-1659-1189
Ömer Faruk Katanalp(DİCLE ÜNİVERSİTESİ, VETERİNER FAKÜLTESİ)0000-0003-3353-1871
Ebru Gökalp Özkorkmaz(DİCLE ÜNİVERSİTESİ, TIP FAKÜLTESİ)0000-0002-1967-4844
İbrahim Yıldızhan(IGDIR UNIVERSITY)0009-0009-6611-088X
Sayfa
400–5
Yayın Tarihi
2023-05-15
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Conclusion: RA has been shown to have predicative influence in the therapy of deltamethrin-induced nephrotoxicity and hepatotoxicity.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Aim: Deltamethrin (DM) is an insecticide and is widely used around the world.
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Temel Bulgular & Veri:Material and Methods: In ours study we used 28 male rats.
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Sonuç & Katkı:Conclusion: RA has been shown to have predicative influence in the therapy of deltamethrin-induced nephrotoxicity and hepatotoxicity.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Deltamethrin · rosmarinic acid · hepatotoxicity

Abstract

Aim: Deltamethrin (DM) is an insecticide and is widely used around the world. Rosmarinic acid (RA) is found in herbs and spices in the Lamiaceae (mint) family and has antioxidant, antiinflammatory and antiapoptotic effects. We objective to examine the protecting efficacy of Rosmarinic acid in preventing the toxic effects of Deltamethrin. Material and Methods: In ours study we used 28 male rats. Group 1: Control group, Group 2: RA group, RA was given 20 mg/kg peroral (p.o.) for 7 days, Group 3: DM group, 35 mg/kg/dose of DM was given 24 hours before sacrification as a single dose by gavage, Group 4: RA+ DM group. Results: BUN, creatinine, AST and ALT values of the RA+DM group were lower than the DM group. TAS and TOS grades were higher in the DM group matched to the RA+DM group. The damage scores of the DM group were higher aacording as those of the RA+DM group. Conclusion: RA has been shown to have predicative influence in the therapy of deltamethrin-induced nephrotoxicity and hepatotoxicity.

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Bu Makaleye Atıf Yap

Yildizhan, E., Ülger, B. V., Akkuş, M., Katanalp, Ö. F., Özkorkmaz, E. G., Yıldızhan, İ. (2023). Rosmarinic Acid Ameliorates Deltamethrin Induced Hepatotoxicity and Nephrotoxicity. Medical Records, Cilt: 5 Sayı: 2, 400–5. https://doi.org/10.37990/medr.1197782

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Kaynakça (29)

  1. REFERENCES 1. Mehlhorn H, Schumacher B, Jatzlau A, et al. Efficacy of deltamethrin (Butox 7.5 pour on) against nymphs andadults of ticks (Ixodes ricinus, Rhipicephalus sanguineus) in treated hair of cattleand sheep. Parasitol Res. 2011; 108 (4): 963-71. doi: 10.1007/s00436-010-2141-2.
  2. Chargui I, Grissa I, Bensassi F, et al. Oxidative stress, biochemical and histopathological alterations in the liver and kidney off male rats exposed to low doses of deltamethrin (DM): a molecular assessment. Biomed Environ Sci. 2012; 25 (6): 672-83. doi: 10.3967/0895-3988.2012.06.009.
  3. Barlow SM, Sullivan FM, Lines J. Risk assessment of the use of deltamethrin on bednets for the prevention of malaria. Food Chem Toxicol. 2001; 39 (5): 407-22. doi: 10.1016/s0278-6915(00)00152-6.
  4. Tuzmen N, Candan N, Kaya E,et al. Biochemical effects of chlorpyrifos and deltamethrin on altered antioxidative defense mechanisms and lipid peroxidation in rat liver. Cell Biochem. Funct. 2008; 26 (1): 119-24. doi: 10.1002/cbf.1411
  5. Tos-Luty S, Haratym-Maj A, Latuszynska J, et al. Obuchowska-Przebirowska D, Tokarska-Rodak M. Oral toxicity of deltamethrin and fenvalerate in Swiss mice. Ann Agric Environ Med. 2001;8 (2):2 45-54.
  6. Scarpati ML, Oriente G. Isolamento e costituzione dell’acido rosmarinico (dal rosmarinus off.). Rice Sci. 1958; 28: 2329–2333
  7. Shetty K, Paliyath G, Pometto AL, et al. Rosmarinic acid biosynthesis and mechanism of action. In Food biotechnology. 2nd ed. CRC Press, Boca Raton, Fla. 2005; 825–845
  8. Pietsch K, Saul N, Chakrabarti S, et al. Hormetins, antioxidants and prooxidants: defining quercetin, caffeic acid- and rosmarinic acid-mediated life extension in C. elegans. Biogerontology. 2011; 12 (4): 329-47. doi: 10.1007/s10522-011-9334-7.
  9. Chu X, Ci X, He J, et al. Effects of a natural prolyl oligopeptidase inhibitor, rosmarinic acid, on lipopolysaccharide-induced acute lung injury in mice. Molecules. 2012; 17 (3): 3586-98. doi: 10.3390/molecules17033586
  10. Rizk HA, Masoud MA, Maher OW. Prophylactic effects of ellagic acid and rosmarinic acid on doxorubicin-induced neurotoxicity in rats. J Biochem Mol Toxicol. 2017; 31:12. doi: 10.1002/jbt.21977.
  11. Mushtaq N, Schmatz R, Ahmed M, et al. Protective effect of rosmarinic acid against oxidative stress biomarkersin liver and kidney of strepotozotocin-induced diabetic rats. J Physiol Biochem. 2015; 71 (4): 743-51. doi: 10.1007/s13105-015-0438-4.
  12. Yang SY, Hong CO, Lee GP, et al. The hepatoprotection of caffeic acid and rosmarinic acid, major compounds of Perilla frutescens, against t-BHP-induced oxidative liver damage. Food Chem Toxicol. 2013; 55: 92-9. doi: 10.1016/j.fct.2012.12.042.
  13. Domitrovic R, Škoda M, Marchesi VV, et al. Rosmarinic acid ameliorates acute liver damage and fibrogenesis in carbon tetrachloride-intoxicated mice. Food Chemical Toxicology. 2013; 51: 370-8. doi: 10.1016/j.fct.2012.10.021
  14. Lee HJ, Cho HS, Park E, et al. Rosmarinic acid protects human dopaminergic neuronal cells against hydrogen peroxide-induced apoptosis. Toxicology. 2008; 250 (2-3): 109-15. doi: 10.1016/j.tox.2008.06.010.
  15. Erel O. A novel automated method to measure total antioxidant response against potent free radical reactions. Clin Biochem. 2004; 37 (2): 112–19. doi: 10.1016/j.clinbiochem.
  16. Erel O. A new automated colorimetric method for measuring total oxidant status. Clin Biochem. 2005; 38 (12): 1103–11. doi: 10.1016/j.clinbiochem.2005.08.008.
  17. Camargo Jr CA, Madden JF, Gao W, et al. Interleukin-6 protects liver against warm ischemia/reperfusion injury and promotes hepatocyte proliferation in the rodent. Hepatology. 1997; 26 (6): 1513–20. doi: 10.1002/hep.510260619.
  18. Chatterjee PK, Cuzzocrea S, Brown PA, et al. Tempol, a membrane permeable radical scavenger, reduces oxidant stress-mediated renal dysfunction and injury in the rat. Kidney Int. 2000; 58 (2): 658–73. doi: 10.1046/j.1523-1755.2000.00212.x.
  19. Erdogan MA, Yalcin A. Protective effects of benfotiamine on irisin activity in methotrexate-induced liver injury in rats. Arch Med Sci. 2018; 16 (1): 205-211. doi: 10.5114/aoms.2018.80002.
  20. Han S, Yang S, Cai Z, et al. Anti-Warburg effect of rosmarinic acid via miR-155 in gastric cancer cells. Drug Des Devel Ther. 2015;9:2695–703. doi: 10.2147/DDDT.S82342
  21. Choi HR, Choi JS, Han YN, et al. Peroxynitrite scavenging activity of herb extracts. Phytother Res. 2002; 16 (4): 364-7. doi: 10.1002/ptr.904
  22. Anand SS, Bruckner JV, Haines WT, et al. Muralidhara S, Fisher JW, Padilla S. Characterization of deltamethrin metabolism by rat plasma and liver microsomes. Toxicol Appl Pharmacol. 2006; 212 (2): 156-66. doi: 10.1016/j.taap.2005.07.021. 23. Myer JR. Acute oral toxicity study of Deltamethrin in rats. International research and Development Corporation, Michigan, USA. Study performed on behalf of Roussel Uclaf, Paris, France. 1989
  23. El-Demerdash FM, Yousef MI, Kedwany FS, et al. Role of alpha-tocopherol and beta-carotene in ameliorating the fenvalerate-induced changes in oxidative stress, hemato-biochemical parameters, and semen quality of male rats. J Environ Sci Health B. 2004; 39 (3): 443-59. doi: 10.1081/pfc-120035929
  24. Yousef MI, El-Demerdash FM, Al-Salhen KS. Protective role of isoflavones against the toxic effect of cypermethrin on semen quality and testosterone levels of rabbits. J. Environ Sci Health. 2003; 38 (4): 463-78. doi: 10.1081/PFC-120021666.
  25. Aydın B. Effects of thiacloprid, deltamethrin and their combination on oxidative stress in lymphoid organs, polymorphonuclear leukocytes and plasma of rats. Pesticide Biochemistry and Physiology. 2011; 100 (2): 165-171. doi:10.1016/j.pestbp.2011.03.006
  26. Ozturk H, Ozturk H, Terzi EH, et al. Protective effects of rosmarinic acid against renal ischaemia/reperfusion injury in rats. J Pak Med Assoc. 2014; 64 (3): 260–5.
  27. Ramalho LN, Pasta ÂA, Terra VA, et al. Rosmarinic acid attenuates hepatic ischemia and reperfusion injury in rats. Food Chem Toxicol. 2014; 74: 270-8. doi: 10.1016/j. fct.2014.10.004, indexed in Pubmed: 25455894
  28. Abdel-Daim MM, Abuzead SMM, Halawa SM. Protective role of Spirulina platensis against acute deltamethrin-induced toxicity in rats. PLoS One. 2013;8 (9): e72991. doi: 10.1371/journal.pone.0072991.
  29. El-Gerbed MSA. Protective effect of lycopene on deltamethrin-induced histological and ultrastructural changes in kidney tissue of rats. Toxicol Ind Health. 2014; 30 (2): 160–73. doi: 10.1177/0748233712448115.